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Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

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Affiliation of Author(s):药学院

Journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First Author:封达

Document Code:923646D81AF64200A8E8F1A20F7518C8

Volume:211

Translation or Not:no

Date of Publication:2021-02-05

Pre One:2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies

Next One:Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility

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