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In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

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Affiliation of Author(s):药学院

Journal:European Journal of Medicinal Chemistry

First Author:康东伟

Indexed by:Unit Twenty Basic Research

Document Code:3423B1A68F9E4D4E991CC3BC4577D04C

Volume:193

Translation or Not:no

Date of Publication:2020-05-01

Pre One:Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

Next One:Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs