医学博士，教授，博士生导师，病原生物学系副主任。中华医学会微生物学和免疫学分会青年委员, 中国微生物学会微生物与免疫学专委会细菌学组委员。山东省感染与免疫学强化重点实验室骨干。人卫出版社全国高等学校长学制临床医学专业规划配套教材编委，中国医药科技出版社全国普通高等医学院校五年制临床医学专业规划教材《医学微生物学》编委，人卫出版社国家医学教育题库副主编。SCI学术期刊审稿人。

近年来主持的课题

1.国家自然科学基金面上项目：幽门螺杆菌调控circRNA m6A甲基化修饰介导胃黏膜上皮细胞恶性转化的机制研究（2021.01-2024.12）

2.国家自然科学基金面上项目：新发现circRNA分子在幽门螺杆菌介导的胃黏膜细胞恶性转化中的作用及分子机制研究（2018.01-2021.12）

3.山东省重点研发计划（公益性科技攻关类）：环状RNA作为幽门螺杆菌相关胃癌分子诊断标志物的研究（2018.01-2019.12）

4.国家自然科学基金面上项目：组蛋白去甲基化酶JMJD2B调控胃癌侵袭转移的机制研究（2014.01-2017.12）

5.国家自然科学基金青年项目：Reptin调节端粒酶活性介导胃癌发生的分子机制 (2011.01-2013.12) 

6.山东省博士后创新基金：JMJD2B作为新的抗肿瘤治疗靶点的研究（2009.01-2010.12）

近年来代表性学术论文

1. Chang M#, Cui X#, Sun Q, Wang Y, Liu J, Sun Z, Ren J, Sun Y, Han L, Li W*. Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21. Cancer Letters. Volume 588, 28 April 2024, 216746 （通讯作者 ）

2.  Xiao S, Zhang L, Wang X, Li W*, Wang X*. The signal conversion strategy using the lytic transglycosylase Cag4-double nanoporous gold co-catalysis for the rapid screening of drugs against Helicobacter pylori infection.Biosensors and Bioelectronics. 23 April 2023, Volume 233, 115345 （共同通讯）

3. Xiao S, Shang K, Li W*, Wang X*. An efficient biosensor based on the synergistic catalysis of Helicobacter pylori urease b subunit and nanoplatinum for urease inhibitors screening and antagonistic mechanism analyzing. Sensors and Actuators: B.Chemical. Volume 355, 15 March 2022, 131284 (共同通讯) 

4.Guo R#, Cui X#, Li X#, Zang W, Chang M, Sun Z, Liu Z, Sun Y, Jia J, Li W*. CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer. Cell Death Dis. 2022 Apr 28;13(4):409 (通讯作者) 

5.Ma F#, Li X#, Ren J, Guo R, Li Y, Liu J, Sun Y, Liu Z, Jia J, Li W*. Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer. Cell Death Dis. 2019 Aug 19;10(9):623. (通讯作者)

6.Jia W#, Zhang J#, Ma F, Hao S, Li X, Guo R, Gao Q, Sun Y, Jia J, Li W*. Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer. Onco Targets Ther. 2019 Aug 19;12:6653-6663（通讯作者)

7.Zhang J#, Ren J#, Hao S, Ma F, Xin Y, Jia W, Sun Y, Liu Z, Yu H, Jia J, Li W*. MiRNA-491-5p inhibits cell proliferation, invasion and migration via targeting JMJD2B and serves as a potential biomarker in gastric cancer. Am J Transl Res. 2018 Feb 15;10(2):525-534. (通讯作者)

8. Han F, Ren J, Zhang J, Sun Y, Ma F, Liu Z, Yu H, Jia J, Li W*. JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. Oncotarget. 2016 Jun 21;7(25):38626-38637. （通讯作者）

9. Zhao L, Li W, Zang W, Liu Z, Xu X, Yu H, Yang Q, Jia J.  JMJD2B promotes epthelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis. Clin Cancer Res. 2013, 19(23):6419-29. (共同第一作者）

10. Ren J, Li W, Yan L, Jiao W, Tian S, Li D, Tang Y, Gu G, Liu H, Xu Z. Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. Br J Cancer. 2011 Dec 6;105(12):1905-11.（共同第一作者）

11. Ren J, Li W, Liu H, Yan L, Jiao W, Li D, Tang Y, Gu G, Xu Z. Overexpression of Reptin in renal cell carcinoma contributes to tumor malignancies and its inhibition triggers senescence of cancer cells. Urol Oncol. 2013 Oct;31(7):1358-66. （共同第一作者）

12. Li W, Zhao L, Zang W, Liu Z, Chen L, Liu T, Xu D, Jia J. Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer. Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):372-8.

13. Li W, Zeng J, Li Q, Zhao L, Liu T, Björkholm M, Jia J, Xu D. Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer. Mol Cancer. 2010 May 30;9:132. 

14. Li W, Ge Z, Liu C, Liu Z, Bjorkholm M, Jia J, Xu D.CIP2A Is Over-expressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence or Differentiation of Tumor Cells. Clinical Cancer Research. 2008,15;14(12):3722-8.

15. Li W, Li L, Liu Z, Liu C, Liu Z, Straat K, Bjorkholm M, Jia J, Xu D. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. Cancer Letters . 2008,260, 28-36.

16. Ge Z, Li W, Wang N, Liu C, Zhu Q, Bjorkholm M, Gruber A, Xu D. Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB J. 2010; 24(2):579-86（ 共同第一作者 ）