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致力于整合疾病类器官模型和高精度单细胞组学测序技术，探究疾病发生发展过程中的分子调控机制。
新型类器官模型构建及评估，解析疾病治疗药物的作用机制及微环境重塑作用，挖掘潜在治疗靶点。
- . Establishment of advanced tumor organoids with emerging innovative technologies. Cancer letters, 598, 2024.
- Yunuo Mao , Wei Wang , Jingwei Yang , Xin Zhou , Yongqu Lu , Junpeng Gao , Xiao Wang , Lu Wen , Wei Fu and Fuchou Tang. Drug repurposing screening and efficacy evaluation based on human colorectal cancer organoids. Protein & cell, 2023.
- Rui Wang , Yunuo Mao , Wendong Wang , Xin Zhou , Wei Wang , Shuai Gao , Jingyun Li , Lu Wen , Wei Fu and Fuchou Tang. Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis. Genome Biology, 2022.
- Rui Wang , Jingyun Li , Xin Zhou , Yunuo Mao , Wendong Wang , Wei Wang , Yuan Gao , Kexuan Chen , Shuntai Yu , Xinglong Wu , Lu Wen , Hao Ge , Wei Fu and Fuchou Tang. Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors. Genome Medicine, 2022.
- Fan Zhou , Rui Wang , Peng Yuan , Yixin Ren , Yunuo Mao , Rong Li , Ying Lian , Junsheng Li , Lu Wen , Liying Yan , Jie Qiao and Fuchou Tang. Reconstituting the transcriptome and DNA methylome landscapes of human implantation. Nature, 2023.
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- （包干项目）构建模拟肿瘤微环境特征的外植体模型探究CD44增敏肝癌响应抗PD-1免疫治疗的作用机制研究, 2024/08/23-2027/12/31
- （包干项目）肝癌类器官培养体系评估及异质性解析, 2024/01/01-2026/12/31
- 山东省自然科学基金青年项目（2023年度，已立项）, 省、市、自治区科技项目
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