MARF1 regulates essential oogenic processes in mice

Journal:Science

Place of Publication:USA

Abstract:Development of fertilization-competent oocytes depends on integrated processes controlling meiosis, cytoplasmic development, and maintenance of genomic integrity. We show that meiosis arrest female 1 (MARF1) is required for these processes in mammalian oocytes. Mutations of Marf1 cause female infertility characterized by up-regulation of a cohort of transcripts, increased retrotransposon expression, defective cytoplasmic maturation, and meiotic arrest. Up-regulation of protein phosphatase 2 catalytic subunit (PPP2CB) is key to the meiotic arrest phenotype. Moreover, Iap and Line1 retrotransposon messenger RNAs are also up-regulated, and, concomitantly, DNA double-strand breaks are elevated in mutant oocytes. Therefore MARF1, by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring.

All the Authors:Koji Sugiura, Fengyun Sun, Janice K Pendola, Gregory A Cox, Mary Ann Handel, John C Schimenti

First Author:You-Qiang Su

Indexed by:Research Articles

Correspondence Author:John J Eppig

Document Code:10.1126/science.1214680

Volume:335

Issue:6075

Page Number:1496-1499

ISSN No.:0036-8075

Translation or Not:no

Date of Publication:2012-03-23

Date of Publication:2012-03-23