教师简介

山东大学特聘教授、博士生导师；曾任江苏省特聘教授、江苏省创新团队领军人才以及科技部国家重大科学研究计划“生殖与发育”项目专家组成员；曾作为项目负责人以及首席科学家承担国家重点研发计划以及国家重大科学研究计划项目各一项。

ORCID iD icon https://orcid.org/0000-0003-3537-6246

ResearcherID: C-6160-2019

Scopus Author ID: 7404457195

教育经历
  • 2002-7 — 2004-10
    美国斯坦福大学
    生殖医学
    博士后
  • 1999-11 — 2002-6
    美国杰克逊研究所
    生殖生物学与发育遗传学
    博士后
  • 1998-10 — 1999-10
    以色列巴伊兰大学
    生殖生物学
    博士后
  • 1995-9 — 1998-6
    中国农业大学
    生理学
    博士生
  • 1993-9 — 1995-6
    中国农业大学
    生理学
    提前转博
  • 1989-9 — 1993-6
    山东农业大学
    畜牧兽医（师范）
    农学学士学位
工作经历
  • 2021-04 — 至今
     生命科学学院  山东大学 
    教授、校特聘教授
  • 2012-05 — 2021-03
     生殖医学国家重点实验室  南京医科大学 
    教授（二级）、特聘教授
  • 2004-11 — 2012-05
     John J. Eppig 实验室，生殖生物学与发育遗传学专业  美国杰克逊实验室 
    副研究员(Associate Research Scientist)
学术兼职
  • 2024-12 — 至今
    中国细胞生物学会-生殖细胞生物学分会常务委员
  • 2014-1 — 2024-12
    中国动物学会生殖生物学分会理事
  • 2014-1 — 至今
    中国生理学会生殖科学专业委员会委员
  • 2017-2 — 至今
    美国生殖研究学会会刊《Biology of Reproduction》编委
  • 2022-11 — 至今
    国际SCI期刊《Journal of Ovarian Research》副主编
  • 2022-12 — 至今
    山东细胞生物学会理事
  • 2023-7 — 至今
    山东省济南市科协科技创新智库专家服务团成员
  • 2019-5 — 2021-5
    江苏省发育生物学会生殖专业委员会第一届委员会主任委员
  • 2014-3 — 2017-3
    发育与生殖研究国家重大科学研究计划专家组成员
研究概况

      本团队主要针对临床对女性不孕、自发流产和出生缺陷等生殖相关疾病的诊疗和防范需求，围绕“决定卵母细胞质量的分子机制” 这一基础研究前沿与临床研究热点，利用小鼠遗传学模型和人类临床资源研究卵母细胞与卵泡发育成熟以及卵子遗传信息稳定传递的机制，以期为揭示临床患者卵母细胞发育成熟缺陷与卵子质量低下的遗传与分子机理，探索非损伤性预测卵母细胞质量的分子标志，改善卵子质量，提高辅助生殖成功率，防止自发流产和出生缺陷等生殖相关疾病提供理论基础和思路。


具体研究内容包括：

1. RNA结合蛋白介导的转录后调控在卵子发生与卵泡发育过程中的作用与机制

2. “卵母细胞-颗粒细胞双向交流”调控卵母细胞与卵泡发育成熟的分子机理

3. 卵母细胞发育成熟障碍与卵子质量下降的遗传与分子基础

（招收以上各方向的硕士、博士研究生和博士后研究人员）

研究方向

1.卵子发生与卵泡发育

论文成果

(1) Yingmei Wang.RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice.Adv Sci (Weinh)..2025,e01973

(2) Hui Luo.Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1-CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition..Clinical and Translational Medicine.2025,15 (1):e70193

(3) Wenwen Liu.VPS34 governs oocyte developmental competence by regulating mito-autophagy-a novel insight into the significance of Rab7 activity and its subcellular location..Advanced Science.2024,11 (41):e2308823

(4) Hui Li.LSM14B is an oocyte-specific RNA-binding protein indispensable for maternal mRNA metabolism and oocyte development in mice..Advanced Science.2023,10 (18):e2300043

(5) Kehan Wang,Feifei Kong.Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)..Autophagy.2023,19 (11):2934-2957

(6) Zhijuan Wang.The oocyte cumulus complex regulates mouse sperm migration in the oviduct..Communications Biology.2022,5 (1):1327

(7) Feifei Yuan,Xiaoqiong Hao.SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation..Cell Death & Disease.2022,13 (11):963

(8) Xiaoli Wei.Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling..Journal of Molecular Cell Biology.2022,14 (7):mjac048

(9) You-Qiang Su.MTOR-mediated interaction between the oocyte and granulosa cells regulates the development and function of both compartments in mice.Biology of Reproduction.2022,107 (1):76-84

(10) Hongdao Zhang.The piRNA pathway is essential for generating functional oocytes in golden hamsters..Nature Cell Biology.2021,23 (9):1013-1022

(11) Xiaolin Chen.mTOR inhibition promotes pneumonitis through inducing endothelial contraction and hyperpermeability..American Journal of Respiratory Cell and Molecular Biology.2021,65 (6):646-657

(12) Shiwen Ni.Coordinated formation of IMPDH2 cytoophidium in mouse oocytes and granulosa cells..Frontiers in Cell and Developmental Biology.2021,9 (690536):45672

(13) Hong Yin.Echinoderm microtubule associated protein like 1 is indispensable for oocyte spindle assembly and meiotic progression in mice..Frontiers in Cell and Developmental Biology.2021,9 (687522):45677

(14) Hui Li.DPAGT1-mediated protein N-glycosylation is indispensable for oocyte and follicle development in mice..Adv Sci.2020,7 (14):2000531

(15) Jiqiang Wang.Combined treatment with cysteamine and leukemia inhibitory factor promotes guinea pig oocyte meiosis in vitro..Am J Transl Res.2019,11 (12):7479-7491

(16) Jing Yang.Transforming growth factor-β is involved in maintaining oocyte meiotic arrest by promoting natriuretic peptide type C expression in mouse granulosa cells..Cell Death Dis.2019,10 (8):558

(17) Pei Xu.Insulin reduces reaction of follicular granulosa cells to FSH stimulation in women with obesity-related infertility during IVF..J Clin Endocrinol Metab.2019,104 (7):2547-2560

(18) Hong Yin.Participation of EML6 in the regulation of oocyte meiotic progression in mice..J Biomed Res.2019,34 (1):44-53

(19) Qingqing Yao.Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice..Proc Natl Acad Sci USA.2018,115 (44):11250-11255

(20) Jing Guo.Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice..Proc Natl Acad Sci USA.2018,115 (23):E5326-E5333

(21) Guang-Yi Cao.Interference with the C-terminalstructure of MARF1 causes defective oocyte meiotic division and female infertility in mice..J Biomed Res.2018,32 (1):58-67

(22) Yoshitaka Kanemitsu.The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain..Sci Rep.2017,7 (1):1155

(23) Jing Zhang.Inhibition of mTOR signaling pathway delays follicle formation in mice..J Cell Physiol.2017,232 (3):585-595

(24) Jing Guo.Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes..J Cell Sci.2016,129 (16):3091-103

(25) You-Qiang Su.Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes..Proc Natl Acad Sci USA,109 (46):18653-60

(26) You-Qiang Su.MARF1 regulates essential oogenic processes in mice.Science.2012,335 (6075):1496-1499

(27) Meijia Zhang.Estradiol promotes and maintains cumulus cell expression of natriuretic peptide receptor 2 (NPR2) and meiotic arrest in mouse oocytes in vitro..Endocrinology.2011,152 (11):4377-4385

(28) Koji Sugiura.Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15..Mol Endocrinol.2010,24 (12):2303-2314

(29) Koji Sugiura.Does bone morphogenetic protein 6 (BMP6) affect female fertility in the mouse?.Biol Reprod.2010,83 (6):997-1004

(30) Meijia Zhang.Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes..Science.2010,330 (6002):366-369

(31) You-Qiang Su.Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling..Mol Endocrinol.2010,24 (6):1230-1239

(32) Mette Nyegaard.Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility..Biol Reprod.2010,82 (6):1129-1138

(33) Koji Sugiura.Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells..Biol Reprod.2009,81 (5):833-841

(34) Koji Sugiura.Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression..Mol Reprod Dev.2009,76 (6):537-547

(35) You-Qiang Su.Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism.Semin Reprod Med.2009,27 (1):32-42

(36) You-Qiang Su.Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells..Development.2008,135 (1):111-121

(37) Cheng-Guang Liang.Mechanisms regulating oocyte meiotic resumption: roles of mitogen-activated protein kinase.Mol Endocrinol.2007,21 (9):2037-2055

(38) Koji Sugiura.Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells.Development.2007,134 (14):2593-2603

(39) You-Qiang Su.Selective degradation of transcripts during meiotic maturation of mouse oocytes..Dev Biol.2007,302 (1):104-117

(40) You-Qiang Su.Participation of mitogen-activated protein kinase in luteinizing hormone-induced differential regulation of steroidogenesis and steroidogenic gene expression in mural and cumulus granulosa cells of mouse preovulatory follicles.Biology of Reproduction.2006,75 (6):859-867

(41) Marco Conti.Role of the epidermal growth factor network in ovarian follicles.Molecular Endocrinol.2006,20 (4):715-723

(42) You-Qiang Su.Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop.Developmental Biology.2004,276 (1):64-73

(43) Jy-Young Park.EGF-like growth factors as mediators of LH action in the ovulatory follicle.Science.2004,303 (5658):682-684

(44) You-Qiang Su.Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex.Developmental Biology.2003,263 (1):126-138

(45) You-Qiang Su.Evidence that multifunctional calcium/calmodulin-dependent protein kinase II (CaM KII) participates in the meiotic maturation of mouse oocytes.Molecular Reproduction and Development.2002,61 (4):560-569

(46) You-Qiang Su.Mitogen-activated protein kinase activity in cumulus cells is essential for gonadotropin-induced oocyte meiotic resumption and cumulus expansion in the mouse.Endocrinology.2002,143 (6):2221-2232

(47) You-Qiang Su.Involvement of MEK-mitogen-activated protein kinase pathway in follicle-stimulating hormone-induced but not spontaneous meiotic resumption of mouse oocytes.Biology of Reproduction.2001,65 (2):358-365

(48) You-Qiang Su.Induction of meiotic resumption in mammalian oocytes.Acta Zoologica Sinica,48 :435-444

专利

1. 一种基于 CRISPER/CAS9 获得MARF1定点突变小鼠模型的构建方法和应用

团队成员
团队名称：
 山东大学生命科学学院女性生殖医学基础研究团队
团队介绍：
 本团队依托山东省细胞与发育生物学重点实验室于2021年成立，团队成员包括山东大学特聘教授1名，副研究员1名，在读博士后1名，博士生4名，硕士生8名、本科生（科创与毕设）多名。本团队主要围绕卵母细胞发育成熟缺陷与卵子质量下降相关的女性不孕与出生缺陷，综合利用遗传学、各种组学与先进的细胞与分子生物学技术开展基础研究。
团队成员：
授课信息

1. 细胞生物学

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