论文成果
MARF1 regulates essential oogenic processes in mice
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发表刊物：
Science
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刊物所在地：
USA
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摘要：
Development of fertilization-competent oocytes depends on integrated processes controlling meiosis, cytoplasmic development, and maintenance of genomic integrity. We show that meiosis arrest female 1 (MARF1) is required for these processes in mammalian oocytes. Mutations of Marf1 cause female infertility characterized by up-regulation of a cohort of transcripts, increased retrotransposon expression, defective cytoplasmic maturation, and meiotic arrest. Up-regulation of protein phosphatase 2 catalytic subunit (PPP2CB) is key to the meiotic arrest phenotype. Moreover, Iap and Line1 retrotransposon messenger RNAs are also up-regulated, and, concomitantly, DNA double-strand breaks are elevated in mutant oocytes. Therefore MARF1, by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring.
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全部作者：
Koji Sugiura, Fengyun Sun, Janice K Pendola, Gregory A Cox, Mary Ann Handel, John C Schimenti
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第一作者：
You-Qiang Su
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论文类型：
Research Articles
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通讯作者：
John J Eppig
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论文编号：
10.1126/science.1214680
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卷号：
335
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期号：
6075
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页面范围：
1496-1499
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ISSN号：
0036-8075
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是否译文：
否
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发表时间：
2012-03-23
上一条：Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice.
下一条：Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.
