论文成果
Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.
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发表刊物：
Science
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刊物所在地：
USA
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摘要：
Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocytes and inhibited meiotic resumption in vitro. Meiotic arrest was not sustained in most Graafian follicles of Nppc or Npr2 mutant mice, and meiosis resumed precociously. Oocyte-derived paracrine factors promoted cumulus cell expression of Npr2 mRNA. Therefore, the granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation, which is critical for maturation and ovulation synchrony and for normal female fertility.
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全部作者：
You-Qiang Su, Koji Sugiura, Guoliang Xia
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第一作者：
Meijia Zhang
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论文类型：
Research Articles
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通讯作者：
John J Eppig
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论文编号：
10.1126/science.1193573
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卷号：
330
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期号：
6002
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页面范围：
366-369
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ISSN号：
0036-8075
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是否译文：
否
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发表时间：
2010-10-15
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