论文成果
Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism
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发表刊物：
Semin Reprod Med
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刊物所在地：
USA
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关键字：
Oocytes, cumulus cells, metabolisms, oocyte-derived factors
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摘要：
Bidirectional communication between oocytes and the companion granulosa cells is essential for the development and functions of both compartments. Oocytes are deficient in their ability to transport certain amino acids and in carrying out glycolysis and cholesterol biosynthesis. Cumulus cells must provide them with the specific amino acids and the products in these metabolic pathways. Oocytes control metabolic activities in cumulus cells by promoting the expression of genes in cumulus cells encoding specific amino acid transporters and enzymes essential for the oocyte-deficient metabolic processes. Hence oocytes outsource metabolic functions to cumulus cells to compensate for oocyte metabolic deficiencies. Oocyte control of granulosa cell metabolism may also participate in regulating the rate of follicular development in coordination with endocrine, paracrine, and autocrine signals. Oocytes influence granulosa cell development mainly by secretion of paracrine factors, although juxtacrine signals probably also participate. Key oocyte-derived paracrine factors include growth differentiation factor 9, bone morphogenetic protein 15, and fibroblast growth factor 8B.
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全部作者：
Koji Sugiura
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第一作者：
You-Qiang Su
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论文类型：
Review
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通讯作者：
John J Eppig
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论文编号：
10.1055/s-0028-1108008
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卷号：
27
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期号：
1
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页面范围：
32-42
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ISSN号：
1526-8004
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是否译文：
否
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发表时间：
2009-01-01
上一条：Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.
下一条：Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells.
