EGF-like growth factors as mediators of LH action in the ovulatory follicle
发布时间：2025-04-30
发表刊物：
Science
刊物所在地：
USA
摘要：
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
第一作者：
Jy-Young Park
通讯作者：
Marco Conti
全部作者：
S-L Catherine Jin, Evelyn Law, Miyako Ariga,You-Qiang Su
