论文成果
EGF-like growth factors as mediators of LH action in the ovulatory follicle
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发表刊物：
Science
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刊物所在地：
USA
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摘要：
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
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全部作者：
You-Qiang Su, Miyako Ariga, Evelyn Law, S-L Catherine Jin
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第一作者：
Jy-Young Park
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论文类型：
Reports
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通讯作者：
Marco Conti
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论文编号：
10.1126/science.1092463
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卷号：
303
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期号：
5658
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页面范围：
682-684
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ISSN号：
1095-9203
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是否译文：
否
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发表时间：
2004-01-30
上一条：Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop
下一条：Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex
