论文成果
EGF-like growth factors as mediators of LH action in the ovulatory follicle
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发表刊物：
Science
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刊物所在地：
USA
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摘要：
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
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全部作者：
You-Qiang Su, Miyako Ariga, Evelyn Law, S-L Catherine Jin
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第一作者：
Jy-Young Park
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论文类型：
Reports
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通讯作者：
Marco Conti
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论文编号：
10.1126/science.1092463
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卷号：
303
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期号：
5658
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页面范围：
682-684
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ISSN号：
1095-9203
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是否译文：
否
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发表时间：
2004-01-30
上一条：Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.
下一条：Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.
