教师简介

王一鹤，副研究员，硕士生导师，山东大学青年学者未来计划获得者。目前研究方向主要集中在以微流控技术为平台的交叉应用领域，如肿瘤类器官芯片、病原微生物检测、仿生高分子材料的开发与应用等研究。

发表论文三十余篇，其中以第一/通讯作者在Advanced Science、Journal of Nanobiotechnology、Advanced Healthcare Materials等国际权威期刊上发表SCI论文十余篇。作为主持人承担国家自然科学基金青年项目，山东省重点研发项目子课题等，作为骨干参与了国家自然科学基金面上项目、国家重点研发计划、青岛市关键技术攻关及产业化示范类项目等。

教育经历
  • 多伦多大学
    化学
    博士生
  • 浙江大学
    化学
    硕士生
  • 中国石油大学（华东）
    应用化学
    学士
工作经历
  •  机械与工业工程系  多伦多大学 
    博士后
研究方向

1.肿瘤类器官芯片

2.病原微生物检测

3.仿生高分子材料

论文成果

(1) 王帅.Concurrent Detection of Amyloid-β Biomarkers via Dual-Channel Graphene Field-Effect Transistor with Liquid-Metal Van Der Waals Contacts for Alzheimer Screening.ACS Sensors.2025,10 (7):5067–5076

(2) 李珺.Bipolar Ionic Diode with a Transformable Polyelectrolyte Network for High-Efficiency Ion Transport and Enhanced Sensitivity in Fluorescence-Based Heavy Metal Ion Detection.Analytical Chemistry.2025,97 (28):15018–15027

(3) 王一鹤.In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies.Journal of Nanobiotechnology.2025 (1)

(4) 邱教艳.High-throughput exosomes analysis for ovarian cancer screening based on a double-positive surface marker detection biochip.BMEMat.2025 :e70015

(5) 王超.Single-cell isolation chip integrated with multicolor barcode array for high-throughput single cell exosomes profiling in tissue samples.Advanced Materials.2025 (37)

(6) 王一鹤,刘梦绮.A Microfluidic 3D-Tumor-Spheroid Model for the Evaluation of Targeted Therapies from Angiogenesis-Related Cytokines at the Single Spheroid Level.Advanced Healthcare Materials.2024,13 (31):2402321

(7) Chao Wang.Microfluidic biochips for single‐cell isolation and single‐cell analysis of multiomics and exosomes.Advanced Science.2024,11 (28):2401263

(8) Mohammad Simchi.High-throughput sperm DNA analysis at the single-cell and population levels.Analyst.2023,148 :3748-3757

(9) 王一鹤.Recent methods of droplet microfluidics and their applications in spheroids and organoids.Lab on a Chip.2023 (23):1080

(10) 宋方腾.Multi-Phenotypic Exosome Secretion Profiling Microfluidic Platform for Exploring Single-Cell Heterogeneity.Small Methods.2022 (2200717)

(11) 王超.High-Throughput, Living Single-Cell, Multiple Secreted Biomarker Profiling Using Microfluidic Chip and Machine Learning for Tumor Cell Classification.Advanced Healthcare Materials.2022,11 (13)

(12) 褚玉金.Rapid and High-Throughput SARS-CoV-2 RNA Detection without RNA Extraction and Amplification by Using a Microfluidic Biochip.chemistry-a European journal.2022,28 (18):e202104054

(13) Jiaoyan Qiu.Lys-AuNPs@MoS2 Nanocomposite Self-Assembled Microfluidic Immunoassay Biochip for Ultrasensitive Detection of Multiplex Biomarkers for Cardiovascular Diseases.Analytical Chemistry.2022,94 (11):4720-4728

(14) Elisabeth Prince.Microfluidic arrays of breast tumor spheroids for drug screening and personalized cancer therapies.Advanced Healthcare Materials.2021,11 (1):2101085

(15) Mohammad Simchi.Selection of high-quality sperm with thousands of parallel channels.Lab on a Chip.2021,21 (12):2464-2475

(16) Jae Bem You.Machine learning for sperm selection.Nat Rev Urol.2021,18 (7):387-403

(17) Christopher McCallum.Deep learning-based selection of human sperm with high DNA integrity.Commun Biol..2019,3 (2):250

(18) Jason Riordon.Two-Dimensional Planar Swimming Selects for High DNA Integrity Sperm.Lab on a Chip.2019,19 (13):2161-2167

(19) Yihe Wang.Prediction of DNA Integrity from Morphological Parameters Using a Single‐Sperm DNA Fragmentation Index Assay.Advanced Science.2019,6 :1900712

专利

1. 一种仿生超疏水-亲水集成孔板及基于该孔板的高通量自动化核酸建库仪

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