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个人信息Personal Information
教授 博士生导师 硕士生导师
主要任职：山东大学附属生殖医院辅助生殖实验室主任
其他任职：山东大学附属生殖医院院长助理
性别：男
毕业院校：山东大学
学历：研究生(博士)毕业
学位：博士生
在职信息：在职
所在单位：妇儿与生殖健康研究院
入职时间：2017-09-14
学科：细胞生物学
办公地点：山东大学附属生殖医院
联系方式：wukeliang_527@163.com
扫描关注
- [1] . The critical role of ZP genes in female infertility characterized by empty follicle syndrome and oocyte degeneration. Fertility and Sterility, 115, 1259, 2021.
- [2] 张传鑫. 2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton. Ecotoxicology and Environmental Safety, 272, 2024.
- [3] 袁慎立. Allelic reprogramming of chromatin states in human early embryos. National Science Review, 11, 2024.
- [4] 刘玉胜. Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes. Nature Communications, 2024.
- [5] Ling Sun. Artificial intelligence system for outcome evaluations of human in vitro fertilization-derived embryos. CHINESE MEDICAL JOURNAL, 2024.
- [6] Yao, Xuan. Tild-CRISPR Allows for Efficient and Precise Gene Knockin in Mouse and Human Cells. Developmental Cell, 45, 526-+, 2018.
- [7] . Developmental toxicity of 2-bromoacetamide on peri- and early post-implantation mouse embryos in vitro. Ecotoxicology and Environmental Safety, 252, 2023.
- [8] . Post-ovulatory aging affects mitochondria, spindle and protein metabolism in mouse oocytes. Reproduction, 2023.
- [9] . Dynamics of histone acetylation during human early embryogenesis. CELL DISCOVERY, 9, 2023.
- [10] . Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition. Nature Structural & Molecular Biology, 30, 200-+, 2023.
- [11] 袁慎立. Human zygotic genome activation is initiated from paternal genome. CELL DISCOVERY, 9, 2023.
- [12] Wang, Jun-Chao. Discs large homologue 1 (Dlg1) coordinates mouse oocyte polarisation during maturation. reproductive fertility and development, 29, 1699-1707, 2017.
- [13] . Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors. GENOME BIOLOGY, 20, 101, 2019.
- [14] Zhu, Meng. Human embryo polarization requires PLC signaling to mediate trophectoderm specification. Elife, 10, 2021.
- [15] . Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. NEW ENGLAND JOURNAL OF MEDICINE, 385, 2047, 2021.
- [16] . Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor.. CELL RESEARCH, 31, 814-817, 2021.
- [17] . A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. 细胞研究（英文版）, 33, 483, 2023.
- [18] . Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy.. CELL RESEARCH, 27, 1069-1072, 2017.
- [19] . The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study. Science China-life sciences, 66, 1697, 2023.
- [20] 陈晓蕾. Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles. BMC PREGNANCY AND CHILDBIRTH, 22, 2022.