• 2016-10 — 2017-09
  美国密歇根大学
  医学院
  国家公派联合培养博士
• 2012-09 — 2018-01
  中国海洋大学
  水生生物学
  理学博士学位
• 2008-09 — 2012-07
  中国海洋大学
  生物科学
  理学学士

• 2022-01 — 至今
   山东大学，海洋学院 
  教授（杰出中青年学者）
• 2018-04 — 2021-09
   美国哥伦比亚大学，遗传发育系 
  博士后/副研究员

• 2024-07 — 至今
  SCI期刊 Discover Oncology 编委会成员
• 2023-01 — 2023-08
  SCI期刊 Microorganisms 特邀编辑
• 2017-07 — 至今
  国际原生生物学家学会（International Society of Protistologists）成员
• 2019-05 — 2021-09
  纽约科学院（New York Academy of Sciences）成员

细胞稳态的表观遗传调控与进化

多种癌症和遗传疾病由表观遗传因子突变导致的细胞稳态维持机制失效所引发，而目前治疗相关疾病的最大障碍是对其稳态维持机制的理解不足。增进对细胞稳态维持的表观遗传调控机制及其进化路径的了解，将有助于发现相关疾病的新靶点，为提出高效、可靠的诊疗策略奠定基础。

1.真核生物细胞稳态的表观遗传调控

2.真核生物的基因组进化

3.疾病相关染色质调控网络

(1) [Nucleic Acids Research, 2025] Comprehensive genome annotation of the model ciliate Tetrahymena thermophila by in-depth epigenetic and transcriptomic profiling

(2) [Science China Life Sciences, 2025] Unveiling an ancient whole-genome duplication event in Stentor, the model unicellular eukaryotes

(3) [Cell, 2024] SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

(4) [Science Advances, 2024] Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

(5) [Nature Communications, 2024] Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer

(6) [Cell Reports, 2024] Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

(7) [Science China Life Sciences, 2024] Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

(8) [BMC Biology, 2024] Genomic insights into the cellular specialization of predation in raptorial protists

(9) [BMC Genomics, 2024] Decryption of the survival "black box": gene family expansion promotes the encystment in ciliated protists

(10) [European Journal of Protistology, 2024] Single-cell transcriptomic analysis reveals genome evolution in predatory litostomatean ciliates

(11) [Cell, 2023] Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

(12) [Nature Communications, 2023] Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma

(13) [Nucleic Acids Research, 2023] Annotation and evaluation of base editing outcomes in multiple cell types using CRISPRbase

(14) [Molecular Phylogenetics and Evolution, 2023] New evidence of consistency between phylogeny and morphology for two taxa in ciliated protists, the subclasses Oligotrichia and Choreotrichia (Protista, Ciliophora)

(15) [Marine Life Science & Technology, 2023] Comparative genome analysis of three euplotid protists provides insights into the evolution of nanochromosomes in unicellular eukaryotic organisms

(16) [Marine Life Science & Technology, 2023] Invasion by exogenous RNA: cellular defense strategies and implications for RNA inference

(17) [European Journal of Protistology, 2023] Single-cell transcriptome reveals cell division-regulated hub genes in unicellular eukaryote Paramecium

(18) [Molecular Cell, 2022] Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

(19) [PNAS, 2022] CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection

(20) [Cell, 2021] Functional interrogation of DNA damage response variants with base editing screens

(21) [PNAS, 2021] Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

(22) [Nature Genetics, 2021] Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

(23) [Nature Communications, 2021] Pparg signaling controls bladder cancer subtype and immune exclusion

(24) [Molecular Cell, 2021] Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

(25) [EMBO Reports, 2021] The interplay between DNA and histone methylation: molecular mechanisms and disease implications

(26) [Nature, 2019] The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

(27) [Molecular Ecology Resources, 2019] Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors

(28) [Molecular Ecology Resources, 2018] GPSit: an automated method for evolutionary analysis of nonculturable ciliated microeukaryotes

(29) [Nucleic Acids Research, 2017] N6-adenine DNA methylation is associated with H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena

(30) [Science China Life Sciences, 2016] Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila

(31) [Protein & Cell, 2015] Phylogenomics of non-model ciliates based on transcriptomic analyses

1. 2024/01 - 2026/12 国家海外高层次人才项目，主持

2. 2024/01 - 2028/12 山东大学“杰出中青年学者”项目，主持

3. 2023/01 - 2026/12 国家自然科学基金面上项目，主持

4. 2023/01 - 2025/12 山东省高等学校青创科技支持计划，主持

5. 2022/07 - 2025/06 江苏省自然科学基金青年科学基金项目，主持

6. 2022/01 - 2027/01 山东大学“齐鲁青年学者”项目，主持

1. 2023年 国家海外高层次人才

2. 2023年 山东大学“杰出中青年学者”

3. 2022年 青岛市科学技术奖自然科学奖一等奖

4. 2021年 山东大学“齐鲁青年学者”

5. 2019年 山东省优秀博士毕业论文

6. 2017年 国际原生生物学家学会“Holz-Conner”奖

1. Recognition of Histone Methylation and DNA by PWWP Domain: Mechanism and Function. In Chromatin Readers in Health and Disease.