徐莉
副教授
访问次数：次
基本信息
  • 教师拼音名称：
    xuli
  • 入职时间：
    2012-06-07
  • 所在单位：
    国家糖工程技术研究中心
  • 学历：
    研究生(博士)毕业
  • 办公地点：
    山东大学青岛校区K6 229
  • 性别：
    女
  • 联系方式：
    xuli_sci@sdu.edu.cn
  • 学位：
    博士生
  • 在职信息：
    在职
  • 毕业院校：
    山东大学，北京大学
  • 硕士生导师
学科：
生物化学与分子生物学；
教师简介

徐莉，山东大学，国家糖工程技术研究中心，副教授

主持或参加科研项目（课题）情况:

1.国家科学技术部, 国家重点研发计划, 2021YFC2103101, 医用多糖生物合成共性机制及透明质酸高产关键技术,子课题5，2021-12 至 2025-11,在研

2.国家科学技术部，国家重点研发计划，2018YFA0902000，以增加水溶性为导向的合成生物学创制课题2，子课题2， 2019-07至2024-06，在研

3.山东省自然科学基金委，面上项目，ZR2021MC104，聚黄酮的酶法合成及其肿瘤细胞靶向递药机制与应用研究，2022-01至2024-12,在研，主持

4.山东省科技厅，山东省重点研发计划，2017GSF21115, 光热与活性氧联合治疗肿瘤的纳米材料的研究结题，2017-01至2018-12,结题，主持

5.国家自然科学基金委员会，青年项目，31301155，细胞外人酪氨酰氧化酶家族蛋白在乳腺癌细胞转移过程中的作用和协同性研究，2014-01至2016-12，结题，主持

6.山东省自然科学基金委员会，青年项目，ZR2013CQ043，人赖氨酰氧化酶类2（hLOXL2）的表达、糖基化和蛋白酶的修饰及其在乳腺癌细胞侵袭过程中的作用， 2013-10至2016-10，结题，主持

代表性论著

(1) Jiasheng Shi, Henan Zhang, Qian Wang, Zhengyu Duan, Li Xu*, Fenghao Guo, Yunfeng Xie*, Zhiyong Chen*; Biomimetic rigid cryogels with aligned micro-sized tubular structures prepared by conventional redox-induced cryopolymerization in a freezer, Chemical Engineering Journal, 2022, 427, 131903

(2) Weiying Hong, Chang-Cheng Liu, Henan Zhang, Zhiyong Chen, Min Xiao*, and Li Xu*; Cancer cell preferential penetration and pH-responsive drug delivery of oligorutin, Biomacromolecules, 2021, DOI:10.1021/acs.biomac.1c00268

(2) Yinping Li#; Weiying Hong#; Henan Zhang#; Tian Tian Zhang; Zhiyong Chen; Shiling Yuan; Peng Peng*; Min Xiao*; Li Xu*; Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy, Journal of Controlled Release, 2020, 317: 232-245.

(3) Tiantian Zhang#; Yinping Li#; Weiying Hong; Zhiyong Chen; Peng Peng; Shiling Yuan; Jingyao Qu; Min Xiao*; Li Xu*; Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy, Journal of Materials Chemistry B, 2019, 7: 2190-2200.

(3) Li Xu#; Xiaohong Liu#; Yinping Li#; Zhenhao Yin; Lan Jin; Lili Lu; Jingyao Qu; Min Xiao*; Enzymatic rhamnosylation of anticancer drugs by an α-L-rhamnosidase from Alternaria sp. L1 for cancer targeting and enzyme activated prodrug therapy, Applied Microbiology and Biotechnology, 2019, 103: 7997-8008.

(4) Li Xu#; Xiaohong Liu#; Zhenhao Yin#; Qian Liu; Lili Lu; Min Xiao*; Sitedirected mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesisyield of reverse hydrolysis based on rational design, Applied Microbiology and Biotechnology, 2016, 100: 10385-10394.

(5) Li Xu; Eden P. Go; Joel Finney; HeeJung Moon; Mason Lantz; Kathryn Rebecchi; Heather Desaire*; Minae Mure*; Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from drosophila S2 cells, Journal of Biological Chemistry, 2013, 288(8): 5357-5363.

专利

(1) 徐莉; 张甜甜; 肖敏; 李银萍; 洪伟英; 一种光热与活性氧联合治疗肿瘤的复合纳米材料的制备方法及应用, 2018-2-27, 中国, 授权公告号CN108273059B

(2) 徐莉; 肖敏; 李银萍; 洪伟英; 张赫男; 一种具有靶向光热治疗和可控释药的多重作用纳米材料的制备方法及应用, 2019-01-18, 中国, 授权公告号CN109589402B

(3)徐莉、肖敏、洪伟英、张赫男、王洋；寡聚芦丁在制备肿瘤靶向产品中的应用及寡聚芦丁-硼替佐米肿瘤靶向递药系统，2021-01-26，中国, 受理号202110098831.7


教育经历
  • 2000-9 — 2008-1
    北京大学
    生物科学类其他专业
    理学博士学位
  • 1996-9 — 2000-7
    山东大学
    生物化学
    理学学士学位
  • 1993-9 — 1996-7
    唐山市唐山一中
工作经历
  • 2012-06-至今
    山东大学国家糖工程技术研究中心
  • 2009-08 — 2012-05
    美国堪萨斯大学化学系
  • 2008-04 — 2009-05
    加拿大滑铁卢大学化学系
研究领域

1、肿瘤免疫治疗

2、多糖等生物大分子理性设计修饰

3、生物分子疾病靶向载药材料研究

4、蛋白质工程

科研成果
论文

1.  安苒. Chitosan/rutin multifunctional hydrogel with tunable adhesion, anti-inflammatory and antibacterial properties for skin wound healing.  Carbohydrate Polymers,  2024. 

2.  Jiasheng Shi. Biomimetic rigid cryogels with aligned micro-sized tubular structures prepared by conventional redox-induced cryopolymerization in a freezer.  Chemical Engineering Journal,  2022. 

3.  阎振鑫. A Novel β-Glucosidase from Chryseobacterium scophthalmum 1433 for Efficient Rubusoside Production from Stevioside..  Frontiers in Microbiology.,  2021. 

4.  杨世达. Novel dTDP- l -Rhamnose Synthetic Enzymes (RmlABCD) From Saccharothrix syringae CGMCC 4.1716 for One-Pot Four-Enzyme Synthesis of dTDP-L-Rhamnose..  Frontiers in Microbiology,  2021. 

5.  王文正. Two-Step Enzymatic Conversion of Rebaudioside A into a Mono-alpha-1,4-Glucosylated Rebaudioside A Derivative.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Journal,  69,  2522, 2021. 

6.  洪伟英. Cancer Cell Preferential Penetration and pH-Responsive Drug Delivery of Oligorutin.  Biomacromolecules,  3679, 2021. 

7.  陈晓迪. Converting a β-N-acetylhexosaminidase into two trans-β-N-acetylhexosaminidases by domain-targeted mutagenesis.  Appl Microbiol Biotechnol.,  2020. 

8.  刘鹏. Screening and characterization of an α-L-fucosidase from Bacteroides fragilis NCTC9343 for synthesis of fucosyl-N-acetylglucosamine disaccharides.  Applied Microbiology and Biotechnology,  2020. 

9.  刘鹏. Screening and characterization of an alpha-L-fucosidase from Bacteroides fragilis NCTC9343 for synthesis of fucosyl-N-acetylglucosamine disaccharides.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY Journal,  104,  7827, 2020. 

10.  王文正. Two-Step Enzymatic Conversion of Rebaudioside A into a Mono-α-1,4-Glucosylated Rebaudioside A Derivative.  Journal of Agricultural and Food Chemistry,  2021. 

11.  范树泉. Cloning, characterization, and production of three α-l-fucosidases from Clostridium perfringens ATCC 13124.  Journal of Basic Microbiology,  56,  347, 2016. 

12.  徐莉. Enzymatic rhamnosylation of anticancer drugs by an alpha-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY Journal,  103,  7997, 2019. 

13.  张甜甜. Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual- modality selective cancer therapy.  Journal of Materials Chemistry B,  7,  2190, 2019. 

14.  靳岚 , 顾国锋 , 王凤山 , 肖敏  and 陈晓迪. Converting a beta-N-acetylhexosaminidase into two trans-beta-N-acetylhexosaminidases by domain-targeted mutagenesis.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY Journal,  104,  661, 2020. 

15.  彭鹏. Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy.  Journal of Controlled Release,  2019. 

16.  肖敏 , 彭鹏 , 苑世领  and 李银萍. Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy.  Journal of Controlled Release,  2020. 

17.  肖敏 , 徐莉 , 曲径遥 , 靳岚  and 何春娟. Rational designed mutagenesis of levansucrase from Bacillus licheniformis 8-37-0-1 for product specificity study.  Applied Microbiology and Biotechnology,  2018. 

18.  徐莉 , 肖敏 , 李银萍 , 靳岚  and 曲径遥. Enzymatic rhamnosylation of anticancer drugs by an α-L-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy.  Applied Microbiology and Biotechnology,  2019. 

19.  肖敏 , 徐莉  and 何春娟. Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822.  BMC Genomics,  2019. 

20.  肖敏 , 徐莉 , 彭鹏 , 苑世领 , 曲径遥  and 张甜甜. Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy.  Journal of Materials Chemistry B,  2019. 

21.  肖敏  and 徐莉. Enzymatic Synthesis of 6’-Sialyllactose , a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-α-Sialidase from Bacteroides fragilis NCTC9343..  Applied and Environmental Microbiology,  2018. 

22.  顾国锋 , 徐莉 , 肖敏  and 齐亭亭. Efficient synthesis of tyrosol galactosides by the beta-galactosidase from Enterobacter cloacae B5.  Applied Microbiology and Biotechnology,  101,  4995, 2017. 

23.  徐莉 , 肖敏  and 靳岚. Purification, cloning, characterization, and N-Glycosylation cnalysis of a novel β-fructosidase from Aspergillus oryzae FS4 synthesizing levan- and neolevan-type fructooligosaccharides.  Plos one,  2014. 

24.  肖敏 , 卢丽丽 , 靳岚  and 徐莉. Galactosylation of caffeic acid by an engineered β-galactosidase.  Drug Discoveries & Therapeutics,  9,  123, 2015. 

25.  肖敏 , 徐莉 , 卢丽丽 , 靳岚  and 顾国锋. Glycosylation of phenolic compounds by the site-mutated β-galactosidase from Lactobacillus bulgaricus L3.  Plos one,  10,  e0121445, 2015. 

26.  肖敏 , 卢丽丽  and 徐莉. Cloning, characterization, and production of three α-l-fucosidases from Clostridium perfringens ATCC 13124.  Journal of Basic Microbiology,  56,  347, 2015. 

27.  肖敏 , 靳岚 , 徐莉  and 卢丽丽. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis.  Plos one,  10,  e0140531, 2015. 

28.  肖敏 , 靳岚 , 顾国锋 , 徐莉  and 卢丽丽. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase.  RSC advances,  2015. 

29.  徐莉  and 肖敏. Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design.  Applied Microbiology and Biotechnology,  2016. 

30.  徐莉. Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted fromDrosophilaS2 Cells.  The journal of Biological Chemistry,  288,  5357, 2013. 

31.  徐莉  and 肖敏. Enzymatic Synthesis of 6’-Sialyllactose , a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-α-Sialidase from Bacteroides fragilis NCTC9343..  Applied and Environmental Microbiology,  2018. 

32.  卢丽丽 , 靳岚 , 徐莉  and 肖敏. Galactosylation of caffeic acid by an engineered β-galactosidase.  Drug Discoveries & Therapeutics,  9,  123, 2015. 

33.  徐莉 , 卢丽丽 , 靳岚 , 顾国锋  and 肖敏. Glycosylation of phenolic compounds by the site-mutated β-galactosidase from Lactobacillus bulgaricus L3.  Plos one,  10,  e0121445, 2015. 

34.  卢丽丽 , 徐莉  and 肖敏. Cloning, characterization, and production of three α-l-fucosidases from Clostridium perfringens ATCC 13124.  Journal of Basic Microbiology,  56,  347, 2015. 

35.  靳岚 , 徐莉 , 卢丽丽  and 肖敏. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis.  Plos one,  10,  e0140531, 2015. 

36.  靳岚 , 顾国锋 , 徐莉 , 卢丽丽  and 肖敏. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase.  RSC advances,  2015. 

37.  曲径遥 , 靳岚 , 肖敏  and 徐莉. Rational designed mutagenesis of levansucrase from Bacillus licheniformis 8-37-0-1 for product specificity study.  Applied microbiology and biotechnology,  2018. 

38.  李银萍 , 靳岚 , 曲径遥 , 肖敏  and 徐莉. Enzymatic rhamnosylation of anticancer drugs by an α-L-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy.  Applied microbiology and biotechnology,  2019. 

39.  曲径遥 , 靳岚 , 徐莉 , 肖敏  and 何春娟. Rational designed mutagenesis of levansucrase from Bacillus licheniformis 8-37-0-1 for product specificity study.  Applied microbiology and biotechnology,  102,  3217, 2018. 

40.  卢丽丽 , 靳岚 , 顾国锋 , 徐莉  and 肖敏. Glycosylation of phenolic compounds by the site-mutated β-galactosidase from Lactobacillus bulgaricus L3.  Plos one,  10,  e0121445, 2015. 

41.  卢丽丽 , 靳岚 , 徐莉  and 肖敏. Galactosylation of caffeic acid by an engineered β-galactosidase.  Drug Discoveries & Therapeutics,  9,  123, 2015. 

42.  靳岚 , 顾国锋 , 徐莉 , 卢丽丽  and 肖敏. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase.  RSC advances,  2015. 

43.  徐莉  and 肖敏. Enzymatic Synthesis of 6’-Sialyllactose , a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-α-Sialidase from Bacteroides fragilis NCTC9343..  Applied and Environmental Microbiology,  2018. 

44.  卢丽丽 , 徐莉  and 肖敏. Cloning, characterization, and production of three α-l-fucosidases from Clostridium perfringens ATCC 13124.  Journal of Basic Microbiology,  56,  347, 2015. 

45.  靳岚 , 徐莉 , 卢丽丽  and 肖敏. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis.  Plos one,  10,  e0140531, 2015. 

46.  顾国锋 , 徐莉 , 肖敏  and 齐亭亭. Efficient synthesis of tyrosol galactosides by the beta-galactosidase from Enterobacter cloacae B5.  Applied microbiology and biotechnology,  101,  4995, 2017. 

47.  肖敏  and 徐莉. Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design.  Applied Microbiology and Biotechnology,  2016. 

48.  肖敏 , 靳岚  and 徐莉. Purification, cloning, characterization, and N-Glycosylation cnalysis of a novel β-fructosidase from Aspergillus oryzae FS4 synthesizing levan- and neolevan-type fructooligosaccharides.  Plos one,  2014. 

49.  徐莉. Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted fromDrosophilaS2 Cells.  The journal of Biological Chemistry,  288,  5357, 2013. 

50.  肖敏  and 徐莉. Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822.  BMC Genomics,  2019. 

51.  彭鹏 , 苑世领 , 曲径遥 , 肖敏  and 徐莉. Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy.  Journal of Materials Chemistry B,  2019. 

专利

1. 寡聚芦丁在制备肿瘤靶向产品中的应用及寡聚芦丁-硼替佐米肿瘤靶向递药系统

2. 一种细菌来源的α-L-鼠李糖苷酶在高效生产橙皮素-7-O-葡萄糖苷中的应用

3. 一种新型高效的β-葡萄糖苷酶CsBGL及其编码基因与应用

4. 一株高效转化甜菊苷为甜茶苷的菌株及其培养方法与应用

5. 一种双功能转糖基α-N-乙酰氨基半乳糖苷酶及其表达基因与应用

6. 一株产β-果糖苷酶的米曲霉菌株及其培养方法与应用

7. 一种具有靶向光热治疗和可控释药的多重作用纳米材料的制备方法及应用

8. 一种光热与活性氧联合治疗肿瘤的复合纳米材料的制备方法及应用

9. 一种α-L-鼠李糖苷酶在制备阿糖胞苷衍生物中的应用

10. 一种α-L-鼠李糖苷酶在制备羟基脲苷衍生物中的应用

11. 一种区域选择性专一的转糖基β-N-乙酰氨基已糖苷酶的应用

12. 一种区域选择性专一的转糖基α-半乳糖苷酶的应用

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