联系方式:247 Beiyuan Road, Jinan,Shandong,250033,China 主要任职:Vice Chair of Department of Neurology, Cheeloo Medical College of SDU 其他任职:Director, Education and Research Division of Neurology, The Second Hospital of Shandong University 学位:医学博士学位 学科:神经病学 在职信息:在职
个人信息 Personal information
在职信息:在职 所在单位:The Second Hospital of Shandong University 入职时间:1994-07-01 办公地点:Chongren Tower, Suite 901 电子邮箱:slxu@sdu.edu.cn
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个人简介 Personal profile
Shunliang Xu, M.D. Ph.D.
ADDRESS: Department of Neurology, The Second Hospital,
Cheeloo Medical College, Shandong University
9th Floor Chongren Building, 247 Beiyuan Road,
Jinan, Shandong, China 250033
TEL: 86-15153169998
EMAIL ADDRESS: slxu@sdu.edu.cn
CURRENT AFFILIATIONS:
2022-Present Vice Chair, Department of Neurology, Cheeloo Medical College, Shandong University
2022-Present Director, Education and Research Division of Neurology at The Second Hospital, Shandong University
2015-Present Academic Advisor for Ph. D Students, Chief Physician, Department of Neurology, The Second Hospital of Shandong University
2005-2015 Associate Professor, Department of Neurology, The Second Hospital of Shandong University
2000-2005 Attending Physician, Department of Neurology, The Second Hospital of Shandong University
1994-1999 Resident, Department of Neurology, The Second Affiliated Hospital of Shandong Medical University
EDUCATION:
2005-2009 Ph.D. in Medicine, School of Medicine Shandong University
Advisor: ENji Han
2007-2009 Visiting PhD student,Department of Human Genetics,Emory University School of Medicine
Advisor: Peng. Jin
2000-2003 M.S in Neurology, School of Medicine Shandong University
1989-1994 M.D. Tongji Medical University, Wuhan, P.R. China
POSTGRADUATE EDUCATION:
2012-2013 Department of Human Genetics
Emory University School of Medicine
Postdoctoral Fellow
Advisor: Peng. Jin
Publications:
1. Zhang J, Wei K, Qu W, Wang M, Zhu Q, Dong X, Huang X, Yi W, Xu S*, Li X*. Ogt deficiency induces abnormal cerebellar function and behavioral deficits of adult mice through modulating RhoA/ROCK signaling. J Neurosci. 2023 May 22:JN-RM-1962-22. doi: 10.1523/JNEUROSCI.1962-22.2023. Epub ahead of print. PMID: 37225434.
2. Xu S*, Teng ZQ, Li X, Li Y*. Editorial: Epigenomic and epitranscriptomic basis of development and human disease. Front Cell Dev Biol. 2023-01-01;11:1128745.
3. Xu Y, Meng Y, Wang P, Sun L, Xu S*. Teaching NeuroImage: Seizures as the Initial Symptom of Relapsing Polychondritis. Neurology. 2022 Feb 8;98(6):e677-e678.doi: 10.1212/WNL.0000000000013144. Epub 2021 Dec 3.
4. Chen L, Shen Q, Xu S. et al. 5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Diagnostic Biomarkers for Late-Onset Alzheimer’s Disease. J ALZHEIMERS DIS. 2022-01-01;85(2):573-585. DOI: 10.3233/JAD-215217
5. Xi Cao, Yanting Chen, Xiaoyu Sang, Shunliang Xu, ZhaohongXie, Zhengyu Zhu, Ping Wang, Jianzhong Bi, and Linlin Xu. Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease. Front Aging Neurosci.2022 Nov 2. doi: 10.3389/fnagi.2022.1013943
6. Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu *, and Yujing Li * Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening. Stem Cells Int. 2022 Aug 25. doi: 10.1155/2022/2150680
7. Jiangbo Xie, Tingting Zhang, Peichun Li, Dong Wang, Tao Liu, and Shunliang Xu * Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis. Drug Des Devel Ther. 2022; 16: 3071–3085.
8. Li Q, Chen J, Liang F, Zhang J, Qu W, Huang X, Cheng X, Zhao X, Yang Z, Xu S*, Li X*. RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in PRC1-independent pattern. Stem Cell Reports. 2021 Dec 14;16(12):2988-3004.doi: 10.1016/j.stemcr.2021.10.013.
9. Cuili Ma, Hwanwook Seong, Yumei Liu, Xiao Yu, Shuanliang Xu*, Yujing Li*.Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers? Frontiers in Bioscience-Landmark. 2021 Oct; 26(10); 895-915DOI: 10.52586/4996
10. Zhou S, Yu X, Wang M, Meng Y, Song D, Yang H, Wang D, Bi J and Xu S* (2021) Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases. Front. Cell Dev. Biol. 2021 Aug; 9:719247. doi: 10.3389/fcell.2021.719247
11. Bian, X., Wang, S., Jin, S. Xu, S., Zhang, H., Wang, D., Shang, W., Wang, P. Two novel missense variants in SPTBN2 likely associated with spinocerebellar ataxia type 5. Neurol Sci 42, 5195–5203 (2021). https://doi.org/10.1007/s10072-021-05204-3
12. Yikai Shou , Feng Liang , Shunliang Xu* , Xuekun Li* The Application of Brain Organoids: From Neuronal Development to Neurological Diseases Front Cell Dev Biol. 2020 Oct 22;8:579659.doi: 10.3389/fcell.2020.579659.
13. Wang D, Wang P, Bian X, Xu S, Zhou Q, Zhang Y, Ding M, Han M, Huang L, Bi J, Jia Y, XieZ . Elevated plasma levels of exosomal BACE1AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease. Mol Med Rep. 2020 Jul;22(1):227-238. doi: 10.3892.
14. Li M, Meng Y, Chu B, Shen Y, Liu X, Ding M, Song C, Cao X, Wang P, Xu L, Wang Y, Xu S, Bi J, Xie Z. Orexin-A aggravates cytotoxicity and mitochondrial impairment in SH-SY5Y cells transfected with APPswe via p38 MAPK pathway. Ann Transl Med. 2020 Jan;8(1):5. doi: 10.21037
15. Shen Y, Ding M, Xie Z, Liu X, Yang H, Jin S, Xu S, Zhu Z, Wang Y, Wang D, Xu L, Zhou X, Wang P, Bi J. Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice. Front Cell Neurosci. 2020 Jan 8;13:568. doi: 10.3389.
16. Li M, Meng Y, Chu B, Shen Y, Xue X, Song C, Liu X, Ding M, Cao X, Wang P, Xu S, Bi J, Xie Z. Orexin-A exacerbates Alzheimer's disease by inducing mitochondrial impairment. Neurosci Lett. 2020 Jan 23;718:134741. doi: 10.1016
17. Wei Y, Sun Z, Wang Y, Xie Z, Xu S, Xu Y, Zhou X, Bi J, Zhu Z.Methylation in the TP53 promoter is associated with ischemic stroke. Mol Med Rep. 2019 Aug;20(2):1404-1410. doi: 10.3892
18. Zhao GJ, Wang ZR, Lin FZ, Cui YS, Xu SL*.The safety and efficacy of tPA intravenous thrombolysis for treating acute ischemic stroke patients with a history of cerebral hemorrhage. Braz J Med Biol Res. 2019 Jan 24;52(2):e7739. doi: 10.1590
19. Ding M, Shen Y, Wang P, Xie Z, Xu S, Zhu Z, Wang Y, Lyu Y, Wang D,Xu L, Bi J, Yang H. Exosomes Isolated from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer's Disease. Neurochem Res. 2018 Nov;43(11):2165-2177. doi: 10.1007/ PMID: 30259257
20. Chi X, Li M, Zhan X, Man H, Xu S, Zheng D, Bi J, Wang Y, Liu C.Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients. ComputBiol Med. 2018 Jan 1;92:73-77. doi: 10.1016.
21. Kong HE, Zhao J, Xu S, Jin P, Jin Y. Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.Front Cell Neurosci. 2017 May 5;11:128. doi: 10.3389
22. Zhou X, Xu Y, Xie Z, Xu S, Bi J. [Association of extracellular superoxide dismutase gene methylation with cerebral infarction].Zhonghua Yi Xue Yi ChuanXue ZaZhi. 2016 Jun;33(3):378-82. doi: 10.3760 PMID: 27264826
23. Liu Z, Wang C, Wang X, Xu S*.Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease. Cell Physiol Biochem. 2015;37(1):321-30. doi: 10.1159. PMID: 26316079
24. Xie ZH, Liu Z, Zhang XR, Yang H, Wei LF, Wang Y, Xu SL, Sun L, Lai C, Bi JZ, Wang XY. Wharton's Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model. Clin Exp Med. 2016 Feb;16(1):89-98. doi: 10.1007
25. Wang Y, Xu S*, Cao Y, Xie Z, Lai C, Ji X, Bi J. Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease. Int J Clin Exp Med. 2014 Aug 15;7(8):1945-57.
26. Li Y, Xu S. RNA Dysfunction and RNA binding Proteins in the Syndrome of ALS/FTD. Journal of Syndromes. June 2013 Vol.:1, Issue:1
27. Wang Y, Xu S*, Liu Z, Lai C, Xie Z, Zhao C, Wei Y, Bi JZ. Meta-analysis on the association between the TF gene rs1049296 and AD. Can J Neurol Sci. 2013 Sep;40(5):691-7. doi: 10.1017 PMID: 23968943
28. Xu S*, Poidevin M, Han E, Bi J, Jin P. Circadian rhythm-dependent alterations of gene expression in Drosophila brain lacking fragile X mental retardation protein. PLoS One. 2012; 7(5):e37937. doi: 10.1371PMID: 22655085.
29. Wei L, Yang H, Xie Z, Yang S, Yang H, Zhao C, Wang P, Xu S, Miao J, Zhao B, Bi J.A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model. Alzheimers Dis. 2012;30(3):531-43. doi: 10.3233/ PMID: 22451314
30. Wang P, Xie ZH, Guo YJ, Zhao CP, Jiang H, Song Y, Zhu ZY, Lai C, Xu SL, Bi JZ. VEGF-induced angiogenesis ameliorates the memory impairment in APP transgenic mouse model of Alzheimer's disease. Biochem Biophys Res Commun. 2011 Aug 5;411(3):620-6. doi: 10.1016PMID: 21771586
31. Xu S. MicroRNAs in Neurodegenerative Disorders. Curr Tran GeriatrGerontol Rep (2012) 1:214–218
32. Wang Y, Xu S*. J (2012) The Association between the MTR Gene A2576G Polymorphism and Alzheimer’s Disease: a Meta Analysis Study. Human Genet Embryol S2:003. doi:10.4172/2161-0436.S2-003
33. Yang Y#, Xu S#, Xia L, Wang J, Wen S, Jin P, Chen D. The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genet. 2009 Apr;5(4):e1000444. doi: 10.1371/ PMID: 19343200 Free PMC article.
34. Shan G, Xu S, Jin P. FXTAS: a bad RNA and a hope for a cure. Expert Opin Biol Ther. 2008 Mar;8(3):249-53. doi: 10.1517/PMID: 18294097
35. Bi JZ, Xu SL, Sun L, Zhou Q, Shang W, Wang X.B[Report of a case with central nuclear type myopathy].Zhong hua Er Ke Za Zhi. 2004 May;42(5):398. PMID: 15189710
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教育经历 Education experience
- [1]2012.6 -- 2013.7
- EMORY 大学 > 研究生(博士后)
Department of Human Genetics Emory University School of Medicine Postdoctoral Fellow
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工作经历 Work experience
暂无内容 -
社会兼职 Professional affiliations
暂无内容 -
研究方向 Research direction
暂无内容 -
团队成员 Team members
[1]Zhai Xixi
Postdoctoral Fellow
[2]Wang Min
Ph.D Student
[3]Zhou Shiyue
[4]Zhang Jinlu
Ph.D Student
[5]Zhao Fuchun
Ph.D Student
[6]Xu Hongjia
Master Student
[7]Han Xiaoxu
Master Student
[8]Zhang Qingshuo
Master Student