Shunliang Xu, M.D.  Ph.D.

ADDRESS: Department of Neurology, The Second Hospital，

Cheeloo Medical College, Shandong University

9th Floor Chongren Building, 247 Beiyuan Road,

Jinan, Shandong, China  250033

TEL: 86-15153169998

EMAIL ADDRESS:  slxu@sdu.edu.cn

CURRENT AFFILIATIONS:

2022-Present  Vice Chair, Department of Neurology, Cheeloo Medical College, Shandong University

2022-Present  Director, Education and Research Division of Neurology at The Second Hospital， Shandong University

2015-Present  Academic Advisor for Ph. D Students, Chief Physician, Department of Neurology, The Second Hospital of                               Shandong University

2005-2015      Associate Professor, Department of Neurology, The Second Hospital of Shandong University

2000-2005      Attending Physician, Department of Neurology, The Second Hospital of Shandong University

1994-1999      Resident, Department of Neurology, The Second Affiliated Hospital of Shandong Medical University

EDUCATION:

2005-2009    Ph.D. in Medicine, School of Medicine Shandong University

                    Advisor: ENji Han

                            2007-2009    Visiting PhD student，Department of Human Genetics，Emory University School of Medicine

                                                          Advisor: Peng. Jin

2000-2003    M.S  in Neurology, School of Medicine Shandong University

                             1989-1994    M.D.  Tongji Medical University, Wuhan, P.R. China

POSTGRADUATE EDUCATION:

2012-2013             Department of Human Genetics

                                     Emory University School of Medicine

                                     Postdoctoral Fellow

                                     Advisor: Peng. Jin  

Publications: 

1. Zhang J, Wei K, Qu W, Wang M, Zhu Q, Dong X, Huang X, Yi W, Xu S*, Li X*. Ogt deficiency induces abnormal cerebellar function and behavioral deficits of adult mice through modulating RhoA/ROCK signaling. J Neurosci. 2023 May 22:JN-RM-1962-22. doi: 10.1523/JNEUROSCI.1962-22.2023. Epub ahead of print. PMID: 37225434.  

2. Xu S*, Teng ZQ, Li X, Li Y*. Editorial: Epigenomic and epitranscriptomic basis of development and human disease. Front Cell Dev Biol. 2023-01-01;11:1128745.

3. Xu Y, Meng Y, Wang P, Sun L, Xu S*. Teaching NeuroImage: Seizures as the Initial Symptom of Relapsing Polychondritis. Neurology. 2022 Feb 8;98(6):e677-e678.doi: 10.1212/WNL.0000000000013144. Epub 2021 Dec 3. 

4. Chen L, Shen Q, Xu S. et al. 5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Diagnostic Biomarkers for Late-Onset Alzheimer’s Disease. J ALZHEIMERS DIS. 2022-01-01;85(2):573-585. DOI: 10.3233/JAD-215217

5. Xi Cao, Yanting Chen, Xiaoyu Sang, Shunliang Xu, ZhaohongXie, Zhengyu Zhu, Ping Wang, Jianzhong Bi, and Linlin Xu.  Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease. Front Aging Neurosci.2022 Nov 2. doi: 10.3389/fnagi.2022.1013943

6. Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu *, and Yujing Li *   Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening. Stem Cells Int. 2022 Aug 25. doi: 10.1155/2022/2150680

7. Jiangbo Xie,   Tingting Zhang,  Peichun Li,  Dong Wang,  Tao Liu,  and  Shunliang Xu * Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis. Drug Des Devel Ther. 2022; 16: 3071–3085.

8. Li Q, Chen J, Liang F, Zhang J, Qu W, Huang X, Cheng X, Zhao X, Yang Z, Xu S*, Li X*. RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in PRC1-independent pattern. Stem Cell Reports. 2021 Dec 14;16(12):2988-3004.doi: 10.1016/j.stemcr.2021.10.013.

9. Cuili Ma, Hwanwook Seong, Yumei Liu, Xiao Yu, Shuanliang Xu*, Yujing Li*.Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers? Frontiers in Bioscience-Landmark. 2021 Oct; 26(10); 895-915DOI: 10.52586/4996

10. Zhou S, Yu X, Wang M, Meng Y, Song D, Yang H, Wang D, Bi J and Xu S* (2021) Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases. Front. Cell Dev. Biol. 2021 Aug; 9:719247. doi: 10.3389/fcell.2021.719247

11. Bian, X., Wang, S., Jin, S. Xu, S., Zhang, H., Wang, D., Shang, W., Wang, P. Two novel missense variants in SPTBN2 likely associated with spinocerebellar ataxia type 5. Neurol Sci 42, 5195–5203 (2021). https://doi.org/10.1007/s10072-021-05204-3

12. Yikai Shou , Feng Liang , Shunliang Xu* , Xuekun Li*  The Application of Brain Organoids: From Neuronal Development to Neurological Diseases  Front Cell Dev Biol. 2020 Oct 22;8:579659.doi: 10.3389/fcell.2020.579659.

13. Wang D, Wang P, Bian X, Xu S, Zhou Q, Zhang Y, Ding M, Han M, Huang L, Bi J, Jia Y, XieZ . Elevated plasma levels of exosomal BACE1AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease. Mol Med Rep. 2020 Jul;22(1):227-238. doi: 10.3892.

14. Li M, Meng Y, Chu B, Shen Y, Liu X, Ding M, Song C, Cao X, Wang P, Xu L, Wang Y, Xu S, Bi J, Xie Z.  Orexin-A aggravates cytotoxicity and mitochondrial impairment in SH-SY5Y cells transfected with APPswe via p38 MAPK pathway. Ann Transl Med. 2020 Jan;8(1):5. doi: 10.21037

15. Shen Y, Ding M, Xie Z, Liu X, Yang H, Jin S, Xu S, Zhu Z, Wang Y, Wang D, Xu L, Zhou X, Wang P, Bi J. Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice. Front Cell Neurosci. 2020 Jan 8;13:568. doi: 10.3389.

16. Li M, Meng Y, Chu B, Shen Y, Xue X, Song C, Liu X, Ding M, Cao X, Wang P, Xu S, Bi J, Xie Z. Orexin-A exacerbates Alzheimer's disease by inducing mitochondrial impairment. Neurosci Lett. 2020 Jan 23;718:134741. doi: 10.1016

17. Wei Y, Sun Z, Wang Y, Xie Z, Xu S, Xu Y, Zhou X, Bi J, Zhu Z.Methylation in the TP53 promoter is associated with ischemic stroke. Mol Med Rep. 2019 Aug;20(2):1404-1410. doi: 10.3892

18. Zhao GJ, Wang ZR, Lin FZ, Cui YS, Xu SL*.The safety and efficacy of tPA intravenous thrombolysis for treating acute ischemic stroke patients with a history of cerebral hemorrhage. Braz J Med Biol Res. 2019 Jan 24;52(2):e7739. doi: 10.1590

19. Ding M, Shen Y, Wang P, Xie Z, Xu S, Zhu Z, Wang Y, Lyu Y, Wang D,Xu L, Bi J, Yang H. Exosomes Isolated from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer's Disease. Neurochem Res. 2018 Nov;43(11):2165-2177. doi: 10.1007/ PMID: 30259257

20. Chi X, Li M, Zhan X, Man H, Xu S, Zheng D, Bi J, Wang Y, Liu C.Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients.  ComputBiol Med. 2018 Jan 1;92:73-77. doi: 10.1016.

21. Kong HE, Zhao J, Xu S, Jin P, Jin Y. Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.Front Cell Neurosci. 2017 May 5;11:128. doi: 10.3389

22. Zhou X, Xu Y, Xie Z, Xu S, Bi J. [Association of extracellular superoxide dismutase gene methylation with cerebral infarction].Zhonghua Yi Xue Yi ChuanXue ZaZhi. 2016 Jun;33(3):378-82. doi: 10.3760 PMID: 27264826

23. Liu Z, Wang C, Wang X, Xu S*.Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease. Cell Physiol Biochem. 2015;37(1):321-30. doi: 10.1159. PMID: 26316079

24. Xie ZH, Liu Z, Zhang XR, Yang H, Wei LF, Wang Y, Xu SL, Sun L, Lai C, Bi JZ, Wang XY. Wharton's Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model. Clin Exp Med. 2016 Feb;16(1):89-98. doi: 10.1007

25. Wang Y, Xu S*, Cao Y, Xie Z, Lai C, Ji X, Bi J. Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease. Int J Clin Exp Med. 2014 Aug 15;7(8):1945-57.

26. Li Y, Xu S. RNA Dysfunction and RNA binding Proteins in the Syndrome of ALS/FTD. Journal of Syndromes. June 2013 Vol.:1, Issue:1

27. Wang Y, Xu S*, Liu Z, Lai C, Xie Z, Zhao C, Wei Y, Bi JZ. Meta-analysis on the association between the TF gene rs1049296 and AD. Can J Neurol Sci. 2013 Sep;40(5):691-7. doi: 10.1017 PMID: 23968943

28. Xu S*, Poidevin M, Han E, Bi J, Jin P. Circadian rhythm-dependent alterations of gene expression in Drosophila brain lacking fragile X mental retardation protein. PLoS One. 2012; 7(5):e37937. doi: 10.1371PMID: 22655085.

29. Wei L, Yang H, Xie Z, Yang S, Yang H, Zhao C, Wang P, Xu S, Miao J, Zhao B, Bi J.A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model. Alzheimers Dis. 2012;30(3):531-43. doi: 10.3233/ PMID: 22451314

30. Wang P, Xie ZH, Guo YJ, Zhao CP, Jiang H, Song Y, Zhu ZY, Lai C, Xu SL, Bi JZ. VEGF-induced angiogenesis ameliorates the memory impairment in APP transgenic mouse model of Alzheimer's disease. Biochem Biophys Res Commun. 2011 Aug 5;411(3):620-6. doi: 10.1016PMID: 21771586

31. Xu S. MicroRNAs in Neurodegenerative Disorders. Curr Tran GeriatrGerontol Rep (2012) 1:214–218

32. Wang Y, Xu S*. J (2012) The Association between the MTR Gene A2576G Polymorphism and Alzheimer’s Disease: a Meta Analysis Study. Human Genet Embryol S2:003. doi:10.4172/2161-0436.S2-003

33. Yang Y#, Xu S#, Xia L, Wang J, Wen S, Jin P, Chen D. The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genet. 2009 Apr;5(4):e1000444. doi: 10.1371/ PMID: 19343200 Free PMC article.

34. Shan G, Xu S, Jin P. FXTAS: a bad RNA and a hope for a cure. Expert Opin Biol Ther. 2008 Mar;8(3):249-53. doi: 10.1517/PMID: 18294097

35. Bi JZ, Xu SL, Sun L, Zhou Q, Shang W, Wang X.B[Report of a case with central nuclear type myopathy].Zhong hua Er Ke Za Zhi. 2004 May;42(5):398. PMID: 15189710