• Name (English):
  Xiaoye Yang
• Name (Pinyin):
  yangxiaoye
• Date of Employment:
  2020-07-30
• School/Department:
  药学院
• Education Level:
  With Certificate of Graduation for Doctorate Study
• Business Address:
  山东省济南市历下区文化西路44号
• Gender:
  Female
• Contact Information:
  yangxiaoye@sdu.edu.cn
• Degree:
  Doctor
• Status:
  Employed
• Alma Mater:
  山东大学
• Supervisor of Master's Candidates

一、基本情况介绍

杨小叶，博士，硕士生导师，山东大学青年学者未来计划入选人。主要从事肿瘤多模态治疗智能纳米体系的研究、新型生物材料的合成及应用等方面的研究。作为项目负责人承担国家自然科学基金青年基金，中国博士后科学基金，山东省自然科学基金等项目。作为第一作者或通讯作者在ACS Nano,Biomaterials, Journal of Controlled Release, Coordination Chemistry Reviews, Biomacromolecules 等国际一流期刊发表学术论文近20篇。作为第一发明人授权中国发明专利1项。

通讯地址：山东省济南市文化西路44号山东大学药学院，250012

邮箱：yangxiaoye@sdu.edu.cn

二、工作和学习经历

2023.09-至今   山东大学，药学院，副教授

2020.07-2023.09 山东大学，药学院，副研究员

2018.07-2020.07 山东大学，基础医学院，博士后

2016.08-2017.08 曼彻斯特大学(University of Manchester)，联合培养博士

2013.09-2018.06 山东大学，药学院，药剂学，硕博连读，博士

2009.09-2013.06 山东大学（威海），药学，学士

三、研究方向

1. 高效铁死亡调控型递药系统的开发及其在疾病治疗中的应用

2. 肿瘤多模态治疗智能纳米体系的设计与开发

3. 新型生物材料的合成及应用

四、主要承担科研项目

1. 国家自然科学基金青年项目

2. 山东省自然科学基金青年项目

3. 山东大学青年学者未来计划

4. 中国博士后科学基金面上资助

5. 山东大学基本科研业务经费

五、教学工作

1. 2023 年山东省研究生创新成果奖：基于铁死亡激活的抗肿瘤联合治疗体系的研究（指导教师）

2. 承担课程：

《药剂学》（本科）；《现代药物制剂技术》（研究生）

六、代表性学术论文

（#第一作者，*通讯作者）

1. Y. Zhang#, X. Du, Z. He, S. Gao, L. Ye, J. Ji, X. Yang*, G. Zhai*. A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity. ACS Nano. 2023;17(12):11537-56.

2. J. Ding#, Z. He, Y. Zhai, L. Ye, J. Ji, X. Yang*, G. Zhai*. Advances in metal-based nano drugs and diagnostic probes for tumor. Coordination Chemistry Reviews. 2024;501:215594.

3. Z. He#, H. Zhou, Q. Feng, Y. Zhang, S. Gao, S. Liu, L. Ye , J. Ji, Y. Xi, X. Yang*, G. Zhai*. A bimetallic dual-targeting nanoplatform for combinational ferroptosis activation/epigenetic regulation/photothermal therapy against breast cancer and tumor microenvironment remodeling. Chemical Engineering Journal. 2024;479:147466.

4. X. Kong#, Z. He, Y. Zhang, Y. Fang, D. Liu, H. Wu, J. Ji, Y. Xi, L. Ye, X. Yang*, G. Zhai*. Intelligent Self-amplifying Ferroptosis-inducible nanoplatform for enhanced tumor microenvironment reconstruction and combination therapy. Chemical Engineering Journal. 2023;468:143729.

5. Z. He#, H. Zhou, Y. Zhang, X. Du, S. Liu, J. Ji, X. Yang*, G. Zhai*. Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment. Biomaterials. 2022;290:121832.

6. Y. Zhang#, X. Du, S. Liu, H. Yan, J. Ji, Y. Xi, X. Yang*, G. Zhai*, NIR-triggerable ROS-responsive cluster-bomb-like nanoplatform for enhanced tumor penetration, phototherapy efficiency and antitumor immunity, Biomaterials, 278 (2021) 121135. 

7. X. Yang#, X. Shi, Y. Zhang, J. Xu, J. Ji, L. Ye, F. Yi, G. Zhai*, Photo-triggered self-destructive ROS-responsive nanoparticles of high paclitaxel/chlorin e6 co-loading capacity for synergetic chemo-photodynamic therapy, Journal of Controlled Release, 323 (2020) 333-349. (IF: 9.776)

8. X. Yang#, X. Shi, R. D'Arcy, N. Tirelli*, G. Zhai*, Amphiphilic polysaccharides as building blocks for self-assembled nanosystems: molecular design and application in cancer and inflammatory diseases, Journal of Controlled Release, 272 (2018) 114-144.

9. Y. Zhang#, N. Qiu, Y. Zhang, H. Yan, J. Ji, Y. Xi, X. Yang*, X. Zhao*, G. Zhai*, Oxygen-carrying nanoparticle-based chemo-sonodynamic therapy for tumor suppression and autoimmunity activation, Biomaterials Science, 9 (2021) 3989-4004.

10. L. Wang#, Y. Zhang, Y. Ma, Y. Zhai, J. Ji*, X. Yang*,G. Zhai*, Cellular drug delivery system for disease treatment. International Journal of Pharmaceutics, 2023;641:123069.

11. D. Liu#, S. Gao, Y. Zhai, X. Yang*, G. Zhai*, Research progress of tumor targeted drug delivery based on PD-1/PD-L1, International Journal of Pharmaceutics, 616 (2022) 121527.

12. X. Yang#, H. Du, J. Liu, G. Zhai*, Advanced nanocarriers based on heparin and its derivatives for cancer management, Biomacromolecules, 16 (2015) 423-436.

13. X. Yang#, X. Cai, A. Yu, Y. Xi, G. Zhai*, Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel, Journal of Colloid and Interface Science, 496 (2017) 311-326.

14. X. Yang#, X. Shi, J. Ji, G. Zhai*, Development of redox-responsive theranostic nanoparticles for near-infrared fluorescence imaging-guided photodynamic/chemotherapy of tumor, Drug Delivery, 25 (2018) 780-796.