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Personal Information:
More >>Associate Professor Supervisor of Master's Candidates
Gender:Male
Education Level:Postgraduate (Postdoctoral)
Biography
Lei Ye
Email:zbwye@tju.edu.cn; leiye@sdu.edu.cn
Address: Meide Building, 44 Wenhuaxi Road, Shandong University, Jinan, 250012, Shandong, China;
Personal homepage: https://faculty.sdu.edu.cn/yelei/zh_CN/index.htm (Chinese)
Biography
Lei Ye received his PhD in Biochemical engineering from Tianjin University in 2016. Upon finishing a postdoctoral training in Bioengineering at the University of Washington at Professor Buddy D Ratner’s lab, in 2019, Dr. Ye joint the faculty of Shandong University. He was selected for the Shandong University Young Scholar’s Future Plan in 2020. As the project leader, 6 projects are under investigation, including the National Natural Science Foundation of China and the Natural Science Foundation of Shandong Province etc., and participated in 1 JDRF project in the United States (2016-2018). Dr. Ye has a strong publication list in international academic journals, such as ACS Nano, Chemical Engineering Journal, International Materials Reviews, Journal of Materials Chemistry A, Materials Today Nano, Acta Biomaterialia, Journal of Nanobiotechnology, etc., and obtained 1 issued patents.
Research Interests
Ye’s research focuses on the design and synthesis of novel functional zwitterionic materials for biomedical and implant device applications.
Ø Biosurface: surface modification for implant devices, such as mesh for hernia repair;
Ø Drug delivery: injectable hydrogel for local drug delivery, such as eye, lung, and cancer;
Ø Clinical application: prevention of postoperative tissue adhesion.
Teaching Interests
Ø Pharmaceutics;
Ø Tissue Engineering and Biomaterials.
Book Chapter
Ø Lei Ye, Fanglian Yao and Junjie Li. Chapter 6 Peptide and protein-based hydrogel; Sustainable Hydrogels: Synthesis, Properties, and Applications. Elsevier Press, ISBN: 978-0-323-91753-7.
Selected Publications(corresponding authors)
15. Zhaoran Wang, Jaiwei Liu, Jiayao Wen, Wei He, Luqing Zhang*, Yabin Zhang*, Lei Ye*, et al. Tri-modal Adhesion Switchable Hydrogel with Precise Regulation ofInterfacial States via a Solvent Microenvironment ReconstructionStrategy; (Chemical Engineering Journal, 2025, 159，164952，IF:13.2)
14. Qiaoyin Hu, Jiayao Wen, Wei He, Guangxi Zhai*, Anchang Liu*, Lei Ye*, et al. Four-dimensional adhesive and shrinkable hydrogels with hemostasis, antibiosis and immunoregulation for enhanced scarless healing of skin wounds; (Chemical Engineering Journal, 2025, 159，164915, IF:13.2)
13. Wei He, Jiayao Wen, Guangxi Zhai, Feng Li*, Lei Ye*, et al. The advances in zwitterionic materials and their biomedical applications; (International Materials Reviews, 2025, 70(4), IF:15.8)
12. Yuelin Fang, Susu Huang, Junjie Li*, Guangxi Zhai*, Lei Ye*, et al. Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy; (ACS Nano, 2023, 17, 24, 24883–24900, IF:17.1, Cover)
11. Rong Wang, Qiaoying Hu, Lei Ye*, Guangxi Zhai*, et al. Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation；(ACS Applied Materials & Interfaces; 2024, 16(3):4071-4088; IF: 9.5)
10. Yabin Zhang, Tianyu Li, Luqing Zhang*,Lei Ye*et al. A highly sensitive and ultra-stretchable zwitterionic liquid hydrogel-based sensor as anti-freezing ionic skin; (Journal of Materials Chemistry A; 2022, 10, 3970, (Back cover); IF: 14.5)
9. Jin Li, Lei Ye*, Guangxi Zhai* et al. A novel liposome-loaded injectable hydrogel with enhanced treatment of choroidal neovascularization by sub-Tenon’s injection;(Materials Today Nano, 2022(20), 100264; IF:13.3)
8. Susu Huang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Zwitterionic biodegradable physical hydrogel based on ATRP technology for effective prevention of Postoperative Tissue Adhesion; (Materials & Design, 2023(227), 111727; IF:8.6)
7. Yuelin Fang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Salt Sensitive Purely Zwitterionic Physical Hydrogel for Prevention of Postoperative Tissue Adhesion; (Acta Biomaterialia; 2022(158), 239; IF:10.6)
6. Yibin Chen, Lei Ye*, Yuanlu Cui*, et al. A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury; (Journal of Nanobiotechnology; 2022, 11;20(1):272.IF:10.4)
5. Huixian Yan, Lei Ye*, Guangxi Zhai* et al., A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy; (Biomaterials Science, 2022(10): 6583;IF: 7.59)
4. Qiu Na, Lei Ye*, Guangxi Zhai*, et al. A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases; (Journal of Nanobiotechnology; 2021, 19:428; IF:10. 4)
3. Yuelin Fang, Lei Ye*, Guangxi Zhai*, et al. Research progress in tumor-targeted immunotherapy; (Expert Opinion on Drug Delivery; 2021, 18(8):1067-1090;IF:8.1)
2. Rong Wang, Lei Ye*, Guangxi Zhai*, et al. Cancer targeted biomimetic drug delivery system; (Journal of drug delivery science and technology; 2021, 63, 2065;IF:5.06)
1. Qirong Tong, Lei Ye*, Guangxi Zhai*, et al. Research progress in bioinspired drug delivery systems; (Expert Opinion on Drug Delivery, 2020, 17(9):1269-1288; IF:8.1)
Patents
1. Lei Ye, Guangxi Zhai, Susu Huang, Yuelin Fang; A physical hydrogel based on zwitterionic modified polysaccharides and its preparation method; National invention patent; Application No: 202210773927.3.
2. Yuanlu Cui, Dong Tianjiao, Xiumei Gao, Lei Ye; A core-shell structure bioadhesive microspheres and its preparation method; National invention patent; Application No: 2013101085252; Publication No.: CN104069228A.
3. Fanglian Yao, Jinmei Wang, Ji Feng, Lei Ye; A method for preparing 3-methyl propane sulfonic acid ammonium propionate modified starch; National invention patent; Application No: 2014102783805; Publication No.: CN104031154A.