叶磊(Lei Ye) (副研究员)

副研究员 硕士生导师

性别:男

学历:研究生(博士后)

学位:博士

在职信息:在职

所在单位:药学院

入职时间:2019-09-12

学科:药剂学

   

个人简介

 

 基本情况     

        叶磊,副研究员,入选山东大学青年学者未来计划。近年来,一直从事抗蛋白粘附材料用于智能纳米诊疗系统、体内植入局部给药以及抗蛋白涂层制备等方面的研究。作为项目负责人承担国家自然科学基金青年项目、山东省自然科学基金等项目6项,参与美国 JDRF 项目1项。以第一作者或通讯作者在ACS Nano,Journal of Materials Chemistry A, Materials Today Nano, Acta Biomaterialia, Journal of Nanobiotechnology等国际期刊发表学术论文10篇。以第一发明人申请中国发明专利2项,国际PCT专利1项。

通讯地址:山东省济南市历下区文化西路44号山东大学趵突泉校区

E-mail: zbwye@tju.edu.cn; leiye@sdu.edu.cn

个人主页 https://faculty.sdu.edu.cn/yelei/en/index.htm  (English)

                  

主要学习和工作经历概述

2019至今 山东大学,药学院,副研究员

2016-2018美国华盛顿大学,博士后;(导师:美国工程院院士Prof. Buddy D. Ratner

       (从事等离子体设备研究,同时基于等离子体技术和两性离子聚合物进行表面抗蛋白涂层制备及其用于药物递送的研究)

2012-2016 天津大学,生物化工(医用高分子),博士(导师: 姚芳莲教授)

      (从事新型抗蛋白粘附材料的开发及其用于纳米载体和凝胶局部给药的研究)

 

研究领域

1. 新型抗蛋白粘附材料的开发及其用于多功能诊疗一体化纳米载体的制备研究

2. 新型抗蛋白粘附材料的开发及其用于可注射水凝胶局部药物递送的研究

3. 新型抗蛋白粘附材料的开发及其用于抗蛋白粘附涂层的体内植入研究

4. 新型抗蛋白粘附材料的开发及其用于体内抗术后肠粘连的研究

 

主要承担项目(主持)

1. 干细胞体外扩增空白平台的构建与高效回收技术的研究;国家自然科学基金青年项目;

2. 两性离子淀粉基电荷可反转诊疗一体化智能递送系统的构建与功效;山东省自然科学基金青年项目;

3. 基于等离子体技术和两性离子材料的抗污涂层的制备研究;山东大学青年学者未来计划;

4. 基于两性离子改性右旋糖酐的长循环-电荷反转-诊疗一体化智能递送系统的研究;山东大学科研项目;

5. 可注射动态双网络水凝胶的研制及其用于干细胞调控和糖尿病足模型的研究;齐鲁医学院科研业项目;

   6. 一种树枝状大分子的结构解析;企业横向;

 

教学工作

本科生课程《药剂学》、《医用水凝胶材料概述》

研究生课程《现代药物制剂技术》

指导一名硕士研究生获得2022年度国家奖学金


代表性科研成果(第一作者/通讯作者)

参编专著

1.     Lei Ye, Fanglian Yao and Junjie Li. Chapter 6 Peptide and protein-based hydrogel; Sustainable Hydrogels: Synthesis, Properties, and Applications. Elsevier 出版社, ISBN: 978-0-323-91753-7.

科研论文 

14. Yuelin Fang, Susu Huang, Junjie Li*, Guangxi Zhai*, Lei Ye*, et al. Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy; (ACS Nano, 2023, 17, 24, 24883–24900, IF:17.1, Cover)

13. Rong Wang, Qiaoying Hu, Lei Ye*,Guangxi Zhai*, et al. Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation (ACS Applied Materials & Interfaces; 2024, DOI: 10.1021/acsami.3c17017; IF: 9.5)

12. Yabin Zhang, Tianyu Li, Luqing Zhang*, Lei Ye* et al. A highly sensitive and ultra-stretchable zwitterionic liquid hydrogel-based sensor as anti-freezing ionic skin; (Journal of Materials Chemistry A; 2022, 10, 3970, (Back cover); IF: 14.5)

11. Jin Li, Lei Ye*, Guangxi Zhai* et al. A novel liposome-loaded injectable hydrogel with enhanced treatment of choroidal neovascularization by sub-Tenon’s injection;(Materials Today Nano, 2022(20), 100264; IF:13.3)

10. Susu Huang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Zwitterionic biodegradable physical hydrogel based on ATRP technology for effective prevention of Postoperative Tissue Adhesion; (Materials & Design, 2023(227), 111727; IF:9.4)

9. Yuelin Fang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Salt Sensitive Purely Zwitterionic Physical Hydrogel for Prevention of Postoperative Tissue Adhesion;  (Acta Biomaterialia; 2023(158), 239; IF:10.6)

8. Yibin Chen, Lei Ye*, Yuanlu Cui*, et al. A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury; (Journal of Nanobiotechnology; 2022, 11;20(1):272. IF:9.4)

7. Huixian Yan, Lei Ye*, Guangxi Zhai* et al., A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy; (Biomaterials Science, 2022(10): 6583; IF: 7.59)

6. Qiu Na, Lei Ye*, Guangxi Zhai*, et al. A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases; (Journal of Nanobiotechnology; 2021, 19:428; IF:10.04)

5. Yuelin Fang, Lei Ye*, Guangxi Zhai*, et al. Research progress in tumor targeted immunotherapy; (Expert Opinion on Drug Delivery; 2021, 18(8):1067-1090; IF:8.1)

4. Rong Wang, Lei Ye*, Guangxi Zhai*, et al. Cancer targeted biomimetic drug delivery system;  (Journal of drug delivery science and technology; 2021, 63, 2065; IF:5.06)

3. Qirong Tong, Lei Ye*, Guangxi Zhai*, et al. Research Progress in Bioinspired Drug Delivery Systems; (Expert Opinion on Drug Delivery, 2020, 17(9):1269-1288; IF:8.1)

2. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Zwitterionic-modified starch-based stealth micelles for prolonging circulation time and reducing macrophage response; (ACS Applied Materials & Interfaces; 2016, 8, 4385-4398; IF: 10.3)

1. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Physical crosslinking starch-based zwitterionic hydrogel exhibiting excellent biodegradability, protein resistance and cytocompatibility; (ACS Applied Materials & Interfaces; 2016, 8, 15710-15723; IF: 10.3)


专利

1. 叶磊,翟光喜,黄苏苏,方跃霖;一种基于两性离子改性多糖的物理凝胶及其制备方法;国家发明专利;申请号:202210773927.3