Lei Ye

Email:zbwye@tju.edu.cn; leiye@sdu.edu.cn

Address: Meide Building,  44 Wenhuaxi Road, Shandong University, Jinan, 250012, Shandong, China;

Personal homepage:  https://faculty.sdu.edu.cn/yelei/zh_CN/index.htm (Chinese)

                                   

Biography                                                                   

Lei Ye received his PhD in Biochemical engineering from Tianjin University in 2016. Upon finishing a postdoctoral training in Bioengineering at the University of Washington at Professor Buddy D Ratner’s lab, in 2019, Dr. Ye joint the faculty of Shandong University. He was selected for the Shandong University Young Scholar’s Future Plan in 2020. As the project leader, 6 projects are under investigation, including the National Natural Science Foundation of China and the Natural Science Foundation of Shandong Province etc., and participated in 1 JDRF project in the United States (2016-2018). Dr. Ye has a strong publication list in international academic journals, such as ACS Nano, Journal of Materials Chemistry A, ACS Applied Materials & Interfaces, Materials Today Nano, Acta Biomaterialia, Journal of Nanobiotechnology, etc., and obtained 1 issued patents.

Research Interests                                                                          

Ye’s research focuses on the design and synthesis of novel functional zwitterionic materials for biomedical and implant device applications.

Ø  Biosurface: surface modification for implant devices, such as mesh for hernia repair;

Ø  Drug delivery: injectable hydrogel for local drug delivery, such as eye, lung, and cancer;

Ø  Clinical application: prevention of postoperative tissue adhesion.

Teaching Interests                                                                

Ø  Pharmaceutics;

Ø  Tissue Engineering and Biomaterials.

Book Chapter                                                                   

Ø  Lei Ye, Fanglian Yao and Junjie Li. Chapter 6 Peptide and protein-based hydrogel; Sustainable Hydrogels: Synthesis, Properties, and Applications. Elsevier Press, ISBN: 978-0-323-91753-7. 

Selected Publications(first and corresponding authors)

                                                       

14. Yuelin Fang, Susu Huang, Junjie Li*, Guangxi Zhai*, Lei Ye*, et al. Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy; (ACS Nano, 2023, Accepted, DOl: 10.1021/acsnano.3c05898; IF:17.1)

13. Rong Wang, Qiaoying Hu, Lei Ye*,Guangxi Zhai*, et al. Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation； (ACS Applied Materials & Interfaces; 2024, DOI: 10.1021/acsami.3c17017; IF: 9.5)

12. Susu Huang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Zwitterionic biodegradable physical hydrogel based on ATRP technology for effective prevention of Postoperative Tissue Adhesion;  (Materials & Design, 2023(227), 111727; IF:9.4)

11. Yuelin Fang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Salt Sensitive Purely Zwitterionic Physical Hydrogel for Prevention of Postoperative Tissue Adhesion;  (Acta Biomaterialia; 2023(158), 239; IF:10.6)

10. Yabin Zhang, Tianyu Li, Luqing Zhang*, Lei Ye* et al., A highly sensitive and ultra-stretchable zwitterionic liquid hydrogel-based sensor as anti-freezing ionic skin. (Journal of Materials Chemistry A; 2022, 10, 3970-3988, (Back Cover); IF: 14.5)

9. Jin Li, Lei Ye*, Guangxi Zhai* et al. A novel liposome-loaded injectable hydrogel with enhanced treatment of choroidal neovascularization by sub-Tenon’s injection. (Materials Today Nano, 2022(20), 100264; IF:13.3)

8. Yibin Chen, Lei Ye*, Yuanlu Cui*, et al. A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury. (Journal of Nanobiotechnology; 2022, 11;20(1):272; IF：10.04)

7. Huixian Yan, Lei Ye*, Guangxi Zhai* et al. A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy. (Biomaterials Science, 2022,10,6583-6600; IF: 7.59)

6.  Qiu Na, Lei Ye*, Guangxi Zhai*, et al. A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases. (Journal of Nanobiotechnology; 2021, 19:428; IF：10.04)

5. Yuelin Fang, Lei Ye*, Guangxi Zhai*, et al. Research progress in tumor targeted immunotherapy. (Expert Opinion on Drug Delivery; 2021, 18(8):1067-1090; IF：8.1)

4. Rong Wang, Lei Ye*, Guangxi Zhai*, et al. Cancer targeted biomimetic drug delivery system;  (Journal of  drug delivery science and technology; 2021, 63, 2065; IF:5.06)

3. Qirong Tong, Lei Ye*, Guangxi Zhai*, et al. Research Progress in Bioinspired Drug Delivery Systems. (Expert Opinion on Drug Delivery, 2020, 17(9):1269-1288; IF：8.1)

2. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Zwitterionic-modified starch-based stealth micelles for prolonging circulation time and reducing macrophage response. (ACS Applied Materials & Interfaces; 2016, 8, 4385-4398; IF: 10.3)

1. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Physical crosslinking starch-based zwitterionic hydrogel exhibiting excellent biodegradability, protein resistance and cytocompatibility. (ACS Applied Materials & Interfaces; 2016, 8, 15710-15723; IF: 10.3)

Patents                                                                        

1.       Lei Ye, Guangxi Zhai, Susu Huang, Yuelin Fang; A physical hydrogel based on zwitterionic modified polysaccharides and its preparation method; National invention patent; Application No: 202210773927.3.  

2.       Yuanlu Cui, Dong Tianjiao, Xiumei Gao, Lei Ye; A core-shell structure bioadhesive microspheres and its preparation method; National invention patent; Application No: 2013101085252; Publication No.: CN104069228A.

3.       Fanglian Yao, Jinmei Wang, Ji Feng, Lei Ye; A method for preparing 3-methyl propane sulfonic acid ammonium propionate modified starch; National invention patent; Application No: 2014102783805; Publication No.: CN104031154A.