Lei Ye

Email:zbwye@tju.edu.cn; leiye@sdu.edu.cn

Address: Meide Building,  44 Wenhuaxi Road, Shandong University, Jinan, 250012, Shandong, China;

Personal homepage:  https://faculty.sdu.edu.cn/yelei/zh_CN/index.htm (Chinese)

                                   

Biography                                                                   

Lei Ye received his PhD in Biochemical engineering from Tianjin University in 2016. Upon finishing a postdoctoral training in Bioengineering at the University of Washington at Professor Buddy D Ratner’s lab, in 2019, Dr. Ye joint the faculty of Shandong University. He was selected for the Shandong University Young Scholar’s Future Plan in 2020. As the project leader, 6 projects are under investigation, including the National Natural Science Foundation of China and the Natural Science Foundation of Shandong Province etc., and participated in 1 JDRF project in the United States (2016-2018). Dr. Ye has a strong publication list in international academic journals, such as ACS Nano, Journal of Materials Chemistry A, ACS Applied Materials & Interfaces, Materials Today Nano, Acta Biomaterialia, Journal of Nanobiotechnology, etc., and obtained 1 issued patents.

Research Interests                                                                          

Ye’s research focuses on the design and synthesis of novel functional zwitterionic materials for biomedical and implant device applications.

Ø  Biosurface: surface modification for implant devices, such as mesh for hernia repair;

Ø  Drug delivery: injectable hydrogel for local drug delivery, such as eye, lung, and cancer;

Ø  Clinical application: prevention of postoperative tissue adhesion.

Teaching Interests                                                                

Ø  Pharmaceutics;

Ø  Tissue Engineering and Biomaterials.

Book Chapter                                                                   

Ø  Lei Ye, Fanglian Yao and Junjie Li. Chapter 6 Peptide and protein-based hydrogel; Sustainable Hydrogels: Synthesis, Properties, and Applications. Elsevier Press, ISBN: 978-0-323-91753-7. 

Selected Publications(first and corresponding authors)

   

  16.Wei He, Jiayao Wen,Li*, Lei Ye*, et al. The advances in zwitterionic materials and their biomedical 

      applications (International Materials Reviews,  Accepted; ID: INR-24-0098.R4, IF:16.8)

15. Yuelin Fang, Susu Huang, Junjie Li*, Guangxi Zhai*, Lei Ye*, et al. Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy; (ACS Nano, 2023, 17, 24, 24883–24900, IF:17.1, Cover)

14. Rong Wang, Qiaoying Hu, Lei Ye*,Guangxi Zhai*, et al. Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation； (ACS Applied Materials & Interfaces; 2024, DOI: 10.1021/acsami.3c17017; IF: 9.5)

13. Jiayao Wen, Susu Huang, Qiaoying Hu, Guangxi Zhai*, Junjie Li*, Lei Ye*, et al. Recent advances in zwitterionic polymers-based non-fouling coating strategies for biomedical applications; (Materials Today Chemistry, 2024, 40, 102232, IF:6.8;(Review))

12. Yabin Zhang, Tianyu Li, Luqing Zhang*, Lei Ye* et al. A highly sensitive and ultra-stretchable zwitterionic liquid hydrogel-based sensor as anti-freezing ionic skin; (Journal of Materials Chemistry A; 2022, 10, 3970, (Back cover); IF: 14.5)

11. Jin Li, Lei Ye*, Guangxi Zhai* et al. A novel liposome-loaded injectable hydrogel with enhanced treatment of choroidal neovascularization by sub-Tenon’s injection;(Materials Today Nano, 2022(20), 100264; IF:13.3)

10. Susu Huang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Zwitterionic biodegradable physical hydrogel based on ATRP technology for effective prevention of Postoperative Tissue Adhesion; (Materials & Design, 2023(227), 111727; IF:9.4)

9. Yuelin Fang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Salt Sensitive Purely Zwitterionic Physical Hydrogel for Prevention of Postoperative Tissue Adhesion;  (Acta Biomaterialia; 2023(158), 239; IF:10.6)

8. Yibin Chen, Lei Ye*, Yuanlu Cui*, et al. A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury; (Journal of Nanobiotechnology; 2022, 11;20(1):272. IF:9.4)

7. Huixian Yan, Lei Ye*, Guangxi Zhai* et al., A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy; (Biomaterials Science, 2022(10): 6583; IF: 7.59)

6. Qiu Na, Lei Ye*, Guangxi Zhai*, et al. A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases; (Journal of Nanobiotechnology; 2021, 19:428; IF:10.04)

5. Yuelin Fang, Lei Ye*, Guangxi Zhai*, et al. Research progress in tumor targeted immunotherapy; (Expert Opinion on Drug Delivery; 2021, 18(8):1067-1090; IF:8.1)

4. Rong Wang, Lei Ye*, Guangxi Zhai*, et al. Cancer targeted biomimetic drug delivery system;  (Journal of drug delivery science and technology; 2021, 63, 2065; IF:5.06)

3. Qirong Tong, Lei Ye*, Guangxi Zhai*, et al. Research Progress in Bioinspired Drug Delivery Systems; (Expert Opinion on Drug Delivery, 2020, 17(9):1269-1288; IF:8.1)

2. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Zwitterionic-modified starch-based stealth micelles for prolonging circulation time and reducing macrophage response; (ACS Applied Materials & Interfaces; 2016, 8, 4385-4398; IF: 10.3)

1. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Physical crosslinking starch-based zwitterionic hydrogel exhibiting excellent biodegradability, protein resistance and cytocompatibility; (ACS Applied Materials & Interfaces; 2016, 8, 15710-15723; IF: 10.3)

Patents                                                                        

1.       Lei Ye, Guangxi Zhai, Susu Huang, Yuelin Fang; A physical hydrogel based on zwitterionic modified polysaccharides and its preparation method; National invention patent; Application No: 202210773927.3.  

2.       Yuanlu Cui, Dong Tianjiao, Xiumei Gao, Lei Ye; A core-shell structure bioadhesive microspheres and its preparation method; National invention patent; Application No: 2013101085252; Publication No.: CN104069228A.

3.       Fanglian Yao, Jinmei Wang, Ji Feng, Lei Ye; A method for preparing 3-methyl propane sulfonic acid ammonium propionate modified starch; National invention patent; Application No: 2014102783805; Publication No.: CN104031154A.