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  近几年主要致力于研究功能化纳米材料的免疫效应及其在生物医学领域的应用。目前,已经主持或参与完成包括国家自然基金青年基金 、国家自然基金面上项目、国家973子课题、国家重点研发计划课题、国家自然科学基金重点项目等多项致力于研究纳米材料生物效应的课题。相关研究成果已经在Cell Death and Disease.Cancer Letters.Plos OneBiomaterialsACS Nano等杂志上发表。参与申请发明专利15项,其中8项已授权。

2021年度拟招收1名硕士研究生。

主持或参加科研项目(课题)(按时间倒序排序):

1. 国家自然科学基金委员会面上项目,21773999,单一表面理化性质渐变的金纳米颗粒库对树突状细胞免疫功能的调节及机制研究,2017-012020-1268.1万元,在研,主持

2. 科技部国家重点研发计划课题,2016YFA0203103,水污染治理所用纳米材料的生物安全性,2016-072021-06890万,在研,参加

3. 国家自然科学基金委员会面上项目,31571422,肿瘤细胞中YIPF2调控TNFRSF10B的分子机制,2016-012019-1265万元,已结题,参加

4. 国家自然科学基金委员会面上项目,81472686CD74调控乳腺癌细胞迁移的分子机制,80万,2015-012018-12,已结题,参加

5. 中国博士后科学基金面上项目,2015M582094,共暴露纳米ZnOPb2+离子对高脂饮食饲喂小鼠的毒性效应及机制研究,2015-112017-115万元,已结题,主持

6. 山东省科技厅面上项目,ZR2014BM026,纳米银对非酒精性脂肪肝小鼠的肝脏毒性及相关机制的研究,2014-122017-1215万元,已结题,主持.

7. 国家自然科学基金委员会面上项目,21077068,环境中碳纳米管生物毒性的分子机制与调控研究,2011-012013-1236万元,已结题,参加

8. 国家自然科学基金委员会重点项目,21137002,典型纳米材料的生物毒性效应及调控研究,2011-082016-12308万元,已结题,参加

9. 科技部973计划子课题,2010CB933504,目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价,2010-012014-08520万元,已结题,参加

10. 国家自然科学基金委员会青年基金,20902054,基于蛋白酶体为靶点的新型铜配体DiS衍生物库的筛选及其抗癌活性研究,2010-012012-1219.0万元,已结题,主持

 

代表性论文

14.Zhang GQ, Fu X, Sun HF, Zhang PY, Zhai, SM, Hao JC, Cui, JW*, Hu M*.  Poly(ethylene glycol)-Mediated Assembly of Vaccine Particles to Improve Stability and Immunogenicity. ACS Appl. Mater. Interfaces, 2021,13(12):13978-13989.

13. Goswami R, Jeon T, Nagaraj H, Zhai SM, Rotello VM*. Accessing Intracellular Targets through Nanocarrier-Mediated Cytosolic Protein Delivery. Trends Pharmacol. Sci., 2020, 41(10):743-754.

12.   Lee YW, Luther DC, Kretzmann JA, Burden A, Jeon T, Zhai SM, Rotello VM*. Protein Delivery into the Cell Cytosol Using Non-Viral Nanocarriers. Theranostics, 2019, 9(11): 3280-3292.

11. Sun HN, Jiang CJ, Wu L, Bai X, Zhai SM*. Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry, Front. Bioeng. Biotechnol., 2019, 7: 414.

10.  Jia JB, Zhang Y, Xin Y, Jiang CJ, Yan B*, Zhai SM*. Interactions between Nanoparticles and Dendritic Cells: from The Perspective of Cancer Immunotherapy, Front. Oncol., 2018, 8: 404.

9. Li F, Zhou XF, Zhou HY, Jia JB, Li LW, Zhai SM* and Yan B*. Reducing Both Pgp Overexpression and Drug Efflux with Anti-Cancer Gold-Paclitaxel Nanoconjugates. Plos One, 2016,11(7), e0160042.

8. Mu Y, Liu YJ, Xiang JB, Zhang Q, Zhai SM, Russo DP, Zhu H, Bai X, Yan B*. From Fighting Depression to Conquering Tumors: A Novel Tricyclic Thiazepine Compound as A Tubulin Polymerization Inhibitor. Cell Death Dis., 2016, 7: e2143

7. Zhang CK#, Zhai SM#, Wu L, Bai YH, Jia JB, Zhang Y, Zhang B, Yan B* Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles. Plos One, 2015, 10(4): e0122591

6. Zhang CK#, Zhai SM#, Li XE, Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, Zhang SS, Su GX, Zhang B, Yan B*. Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death Dis., 2014, 5, e1138.

5.  Jiang CJ, Jia JB, Zhai SM*. Mechanistic Understanding of Toxicity from Nanocatalysts. Int. J. Mol. Sci., 2014, 15, 13967-13992.

4. Wu L, Zhang Y, Zhang CK, Cui XH, Zhai SM, Liu Y, Yan B*. Tuning Cell Autophagy by Diversifying Carbon Nanotube’s Surface Chemistry. ACS Nano, 2014, 8(3): 2087-2099.

3. Zhang RN, Pan XH, Li F, Lin Z, Zhai SM, Mu QX, Liu JF, Qu GB, Jiang GB, Yan B.* Cell Rescue by Nano-Sequestration: Reduced Cytotoxicity of An Environmental Remediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct. Environ. Sci. Technol., 2014, 48(3):1984-92.

2.  Liu AJ, Zhai SM, Zhang B, Yan B.* Analytical Strategies for Real-Time and Non-Invasive Tracking of 2. Carbon Nanomaterials in vivo. TRAC-Trend Anal. Chem., 2013, 48, 1-13.

1. Wang F#, Zhai SM #, Liu XJ, Li LW, Wu S, Dou QP *, Yan B*, A Novel Dithiocarbamate Analogue with Potentially Decreased ALDH Inhibition Has Copper-Dependent Proteasome-Inhibitory and Apoptosis-Inducing Activity in Human Breast Cancer Cells, Cancer lett., 2011, 300(1): 87-95.