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个人信息Personal Information
教授 博士生导师 硕士生导师
性别：男
毕业院校：山东大学
学历：研究生(博士)毕业
学位：医学博士学位
在职信息：在职
所在单位：药学院
入职时间：2013-02-28
联系方式：zhangyingjie@sdu.edu.cn
扫描关注
- [101] 徐文方 and 张颖杰. Design, Synthesis and Biological Evaluation of Novel Tamibarotene Derivative as Multitarget Anticancer Agent. Lett. Drug Des. Discov., 2016.
- [102] 徐文方 and 张颖杰. Discovery of BC-01, a novel mutual prodrug (hybrid drug) of ubenimex and fluorouracil as anticancer agent. Eur. J. Med. Chem., 2016.
- [103] 徐文方 and 张颖杰. Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors. Bioorg. Med. Chem., 2016.
- [104] 徐文方 and 张颖杰. Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU. Med. Chem., 2016.
- [105] 张颖杰. Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation. Eur. J. Med. Chem., 2016.
- [106] 徐文方 and 张颖杰. Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity. Eur. J. Med. Chem., 2015.
- [107] 徐文方 and 张颖杰. Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold. Drug Des. Dev. Ther., 2015.
- [108] 张彩 and 张颖杰. Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by induction p21WAF1 expression and cell cycle arrest. Anti-Cancer Drugs, 2014.
- [109] 徐文方 and 张颖杰. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorg. Med. Chem., 2015.
- [110] 张颖杰. Development of N-hydroxybenzamide derivatives with indole containing cap group as histone deacetylases inhibitors. Bioorg. Med. Chem., 2015.
- [111] 徐文方 and 张颖杰. Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro.. Bioorg. Med. Chem., 2015.
- [112] 张颖杰. Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity. Bioorg. Med. Chem., 2015.
- [113] 徐文方 and 张颖杰. Histone deacetylase inhibitors merged with protein tyrosine kinase inhibitors. Drug Discov. Ther., 2015.
- [114] 徐文方 and 张颖杰. Design, Synthesis and Antitumor Evaluation of Novel Histone Deacetylase (HDAC) Inhibitors Equipped with Phenylsulfonylfuroxan Module as Nitric Oxide (NO) Donor. J. Med. Chem., 2015.
- [115] 徐文方 and 张颖杰. Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse. Drug Discov. Ther., 2015.
- [116] 徐文方 and 张颖杰. Isoform-selective histone deacetylase inhibitors: the trend and promise of disease treatment. Epigenomics, 2015.
- [117] 徐文方 and 张颖杰. VEGF signal system: the application of antiangiogenesis.. Curr. Med. Chem., 2014.
- [118] 徐文方 and 张颖杰. Discovery of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl) -sulfonamide derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological .... Bioorg. Med. Chem., 2014.
- [119] 徐文方 and 张颖杰. Progress of HDAC inhibitor panobinostat in the treatment of cancer. Curr. Drug Targets, 2014.
- [120] 徐文方 , 刘新泳 and 张颖杰. Discovery of N-substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase. J. Med. Chem., 2014.