Yongqiang Zhang

Professor of Organic Chemistry

School of Chemistry and Chemical Engineering, Shandong University

Address: Shanda South Rd 27, Jinan, 250100, P. R. China

Phone: +86 13176778768

Email: yongqzhang@sdu.edu.cn

Education & Work Experience

2019-          Professor, Shandong University

2018-2018  Postdoc, Pharmaceutical Institute, Bonn University, Advisor: Prof. Christa E. Müller

2014-2018  Humboldt Fellow, Kekulé-Institute, Bonn University, Advisor: Prof. Andreas Gansäuer

2012-2013  Postdoc, Georgia State University, Advisor: Prof. Hao Xu

2006-2011  Ph.D. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Advisor: Prof. Yongqiang Tu

2002-2006  B.S. Lanzhou University, Advisor: Prof. Yongqiang Tu

Research Interests

1. Asymmetric Hydrogen Atom Transfer (HAT)

2. Transition-metal Catalyzed Radical Reactions

3. Natural Product Synthesis and Pharmaceutical Chemistry

Highly motivated undergraduate students, graduate students and researchers are welcomed to visit and join us!

Publications

21. Zhang, Y. –Q.; Bohle. F.; Bleith, R.; Schnakenburg, G.; Grimme, S.*; Gansäuer, A.*. Synthesis of 1,3-amino alcohols by hydroxyl-directed aziridination and aziridine hydrosilylation.

Angew. Chem. Int. Ed. 2018, 57, 13528-13532.

20. Zhang, Y. -Q.; Vogelsang, E.; Qu, Z.-W.; Grimme, S.; Gansäuer, A.*. Titanocene-catalyzed radical opening of N-acylated aziridines.

Angew. Chem. Int. Ed. 2017, 56, 12654-12657.

(Highlighted by Synfacts, 2017, 13, 1303.)

19. Zhang, Y. -Q.; Poppel, C.; Panfilova, A.; Bohle, F.; Gansäuer, A.*. SN2 at tertiary carbon centers in epoxides.

Angew. Chem. Int. Ed. 2017, 56, 9851-9854.

18. Zhang, Y. -Q.; Jakoby, V.; Stainer, K.; Schmer, A.; Klare, S.; Bauer, M.; Grimme, S.; Cuerva, J. M.; Gansäuer, A.*. Amide-substituted titanocenes in HAT-catalysis.

Angew. Chem. Int. Ed. 2016, 55, 1523-1526.

(Front cover, hot paper)

17. Zhang, Y. -Q.; Funken, N.; Winterscheid, P.; Gansäuer, A.* Hydroxy-directed, fluoride-catalyzed epoxide Hydrosilylation for the synthesis of 1,4-Diols.

Angew. Chem. Int. Ed. 2015, 54, 6931-6934.

(Highlighted by Org. Chem. Highlights 2016, March 21)

16. Funken, N.#; Zhang, Y. –Q. #; Gansäuer, A.*. Regiodivergent catalysis: A powerful tool for selective catalysis. (#equal contribution)

Chem. Eur. J. 2017, 23, 19-32.

15. Zhang, Y. -Q.; Yuan, Y. –A.; Liu, G. –S.; Xu, H.*. Iron(II)-catalyzed intramolecular asymmetric aminohydroxylation of indoles.

Org. Lett. 2013, 15, 3910-3913.

(Highlighted by Synfacts 2013, 9, 1204.)

14. Zhang, Y. -Q.; Zhu, D. -Y.; Li, B. -S.; Tu, Y. -Q.*; Liu, J. -X.; Lu, Y.; Wang,S. –H.. Palladim-Catalyzed cascade process to construct 1,2,5-trisubstituted pyrroles.

J. Org. Chem. 2012, 77, 4167-4170.

13. Zhang, Y. -Q.; Zhu, D. -Y.; Jiao, Z. -W.; Li, B. -S.; Zhang, F. -M.; Tu, Y. -Q.*; Bi, Z.. Regiodivergent annulations of alkynyl indoles to construct spiro-pseudoindoxyl and tetrahydro-β-carbolines.

Org. Lett. 2011, 13, 3458-3461.

12. Zhang, Y. -Q.; Chen, Z. -H.; Tu, Y. -Q.*; Fan, C. -A.; Zhang, F. -M.; Wang, A. -X.; Yuan, D. -Y.. Gold-catalyzed reaction of enynols by a dimerization-fragmentation process: An expeditious assembly of enyne molecular architecture.

Chem. Commun. 2009, 45, 2706-2708.

11. Zhang, Y. -Q.#; Liu, J. –D.#; Xu, H.*. Copper(II)-catalyzed trifluoromethylation of N-aryl imines. (# equal contribution)

Org. Biomol. Chem. 2013, 11, 6242-6245.

10. Zhu, C.#; Zhang, Y. -Q.#;Yuan, Y.-A.; Xu, H.*. Copper-catalyzed aerobic C-H trifluoromethylation of phenanthrolines.  (# equal contribution)

Synlett 2015, 26, 345-349.

9. Liu, G. -S.; Zhang, Y. -Q.; Yuan, Y. -A.; Xu, H.*. Iron (II) catalyzed intramolecular aminohydroxylation of olefins with functionalized hydroxylamines.

J. Am. Chem. Soc. 2013, 135, 3343-3346.

8. Chen, Z.-H.; Zhang, Y. -Q.; Chen, Z.-M.; Tu, Y. -Q.*; Zhang, F. -M.. Total synthesis of (±)-maistemonine and (±)-stemonamide.

Chem. Commun. 2011, 47, 1836-1838.

7. Chen, Z.-H.; Chen, Z.-M.; Zhang, Y. -Q.; Tu, Y. -Q.*; Zhang, F. -M.. Total synthesis of (±)-maistemonine, (±)-stemonamide, and (±)-isomaistemonine.

J. Org. Chem. 2011, 76, 10173-10186.

6. Li, B. -S.; Yang, B. -M.; Wang, S. -H.; Zhang, Y. -Q.; Cao, X. -P.; Tu, Y. -Q.* Copper(I)-catalyzed intramolecular [2 + 2] cycloaddition of 1,6-enyne-derived ketenimine: An efficient construction of strained and bridged 7-substituted-3-heterobicyclo[3.1.1]heptan-6-one.

Chem. Sci. 2012, 3, 1975-1979.

5. Jiao, Z. –W; Zhang, S. -Y.; Tu, Y. -Q.*; Wang, S. -H.; Zhang, F. -M.; Zhang, Y. -Q.; Li, H.; He, C. Organocatalytic Asymmetric Direct C-H Functionalization of Ethers: A highly efficient approach to chiral spiroethers.

Angew. Chem., Int. Ed. 2012, 51, 8811-8815.

4. Zhao, X.; Zhang, E.; Tu, Y. -Q.*; Zhang, Y. -Q.; Yuan, D. -Y.; Cao, K.; Fan, C. -A.; Zhang, F. -M.. Au(I)-catalyzed rearrangement reaction of propargylic aziridine: synthesis of trisubstituted and cycloalkene-fused Pyrroles.

Org. Lett. 2009, 11, 4002-4004.

3. Zhang, X. -M.; Tu, Y. -Q.*; Jiang, Y. -J.; Zhang, Y. -Q.; Fan, C. -A.; Zhang, F. -M.. Tandem reactions of cis-2-acyl-1-alkynyl-1-aryl cyclopropanes tuned by gold(I) and silver(I) catalysts: Efficient synthesis of pyran-fused indene cores and 2,4,6-trisubstituted phenols.

Chem. Commun. 2009, 45, 4726 -4728.

2. Liu, J. -D.; Wang, S. -H.; Zhang, F. -M.; Tu, Y. -Q.*; Zhang, Y. -Q.. Concise total synthesis of (±)-crinine. 

Synlett 2009, 18, 3040 -3042.

1. Zhang, F. -M.; Tu, Y. -Q.*; Liu, J. -D.; Fan, X. -H.; Shi, L.; Hu, X. -D.; Wang, S. -H.; Zhang, Y. -Q.. A general approach to crinine-type Amaryllidaceae alkaloids: total syntheses of (±)-haemanthidine, (±)-pretazettine, (±)-tazettine, and (±)-crinamine. 

Tetrahedron 2006, 62, 9446-9455.