2002年和2007年在南开大学获得微生物学专业学士和博士学位，2007至2011年在亚利桑那州立大学进行博士后研究，2011年加入中国科学院青岛生物能源与过程研究所，获得中国科学院“百人计划”支持，2020年调入山东大学微生物技术研究院。2017年获国家自然科学基金委员会“优秀青年科学基金”和“山东省自然科学杰出青年基金”资助。已在Nat Commun、Nucleic Acids Res、Metab Eng、PNAS、Bioresour Technol等国际主流刊物上发表SCI论文50余篇，参与撰写英文书籍章节2章，申请发明专利30余项，其中10项已获得授权。

办公地点：山东大学青岛校区淦昌苑A座418

电子邮箱：zhaoguang@sdu.edu.cn

2022年招收硕士研究生2名，欢迎联系咨询！！

• 2002-09-01-2007-06-30
  南开大学
  微生物学
• 1998-09-01-2002-06-28
  南开大学
  微生物学

• 2020-02 — Now
  山东大学
• 2011-05 — 2020-01
  中国科学院青岛生物能源与过程研究所
• 2007-09 — 2011-04
  亚利桑那州立大学

1. 细菌基因调控机制

2. 微生物代谢工程

(1)包子娴. Smart Bacterial Cellulose–Methylacrylated Chitosan Composite Hydrogel: Multifunctional Characterization for Real-Time pH Monitoring .polymers .2025 (7)

(2)隋新悦. Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation .Microorganisms .2025 ,13 (1)

(3) Metabolic Engineering of Escherichia coli for Bioproduction of (R)-3-Hydroxybutyric Acid through a Three-Pronged Approach .Journal of Agricultural and Food Chemistry .2024 ,72 (30):16848

(4)蒋波. Adaptive Evolution for the Efficient Production of High-Quality d-Lactic Acid Using Engineered Klebsiella pneumoniae .Microorganisms .2024 ,12 (6)

(5)隋新悦. Phenolic compounds induce ferroptosis-like death by promoting hydroxyl radical generation in the Fenton reaction .Communications Biology .2024 ,7 (1)

(6)Liu, Xiutao. Optimization strategies for CO2 biological fixation .BIOTECHNOLOGY ADVANCES .2024 ,73

(7)郭李坤. Using a synthetic machinery to improve carbon yield with acetylphosphate as the core .NATURE COMMUNICATIONS .2023 (14):5286

(8)赵喆. Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response .MSYSTEMS .2022 (7)

(9) Lysine acetylation of Escherichia coli lactate dehydrogenase regulates enzyme activity and lactate synthesis .FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY .2022 (10)

(10) Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase .Engineering Microbiology .2022 (2)

(11)赵广. Bacterial protein acetylation and its role in cellular physiology and metabolic regulation. .BIOTECHNOLOGY ADVANCES .2021 ,53 (53):107842

(12)赵广. Biosynthesis of acetylacetone inspired by its biodegradation .BIOTECHNOLOGY FOR BIOFUELS .2020 (13)

(13)赵广. Comparison of Glucose, Acetate and Ethanol as Carbon Resource for Production of Poly(3-Hydroxybutyrate) and Other Acetyl-CoA Derivatives .Frontiers in Bioengineering and Biotechnology .2020 (8)

(14)赵广. An acid-tolerance response system protecting exponentially growing Escherichia coli .NATURE COMMUNICATIONS .2020 (11)

(15)赵广. Characterization and directed evolution of propionyl-CoA carboxylase and its application in succinate biosynthetic pathway with two CO2 fixation reactions .Metabolic Engineering .2020 (62: 42–50)

(16)赵广. Characterization and directed evolution of propionyl-CoA carboxylase and its application in succinate biosynthetic pathway with two CO2 fixation reactions .Metabolic Engineering .2020 (62： 42-50)

(17)赵广. A fast and robust iterative genome-editing method based on a Rock-Paper-Scissors strategy .Nucleic Acids Research .2020 (49)

(18)赵广. A fast and robust iterative genome-editing method based on a Rock-Paper-Scissors strategy .Nucleic Acids Research. .2020 (49)

(19) Biochemical routes for uptake and conversion of xylose by microorganisms .Biotechnol Biofuels .2020 ,13 :21

(20) Highly efficient biosynthesis of hypoxanthine in Escherichia coli and transcriptome-based analysis of the purine metabolism .ACS Synth Biol .2020

(21) Coupled biosynthesis and esterification of 1,2,4-butanetriol to simplify its separation from fermentation broth .Eng Life Sci .2019 ,19 :444-451

(22) Metabolic engineering of a xylose pathways for biotechnological production of glycolate in Escherichia coli .Microb Cell Fact .2018 ,17 :51

(23) Production of D-lactate from glucose using Klebsiella pneumoniae mutants. .Microb Cell Fact .2017 ,16 :209

(24) A novel autolysis system controlled by magnesium and its application to poly(3-hydroxypropionate) production in engineered Escherichia coli .Bioengineered .2017 ,8 (5):594-9

(25) Improving the production of acetyl-CoA-derived chemicals in Escherichia coli BL21(DE3) through iclR and arcA deletion .BMC Microbiol .2017 ,17 :10

(26) Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis. .Crit Rev Biotechnol .2016 ,37 (7):933-41

(27) Functional balance between enzymes in malonyl-CoA pathway for 3-hydroxypropionate biosynthesis .Metab Eng .2016 ,34 :104-11

(28) Biosynthetic pathway for acrylic acid from glycerol in recombinant Escherichia coli .Appl Mircobiol Biotechnol .2016 ,100 (11):4901-7

(29) Deletion of arcA increased the production of acetyl-CoA-derived chemicals in recombinant Escherichia coli .Biotechnol Lett .2015 ,38 (1):97-101

(30) Production of optically pure D-lactate from glycerol by engineered Klebsiella pneumoniae strain .Bioresour Technol .2014 ,172 :269-75

(31) Metabolic engineering of Escherichia coli for poly (3-hydroxypropionate) production from glycerol and glucose .Biotechnol Lett .2014 ,36 (11):2257-62

(32) Development of genetically stable Escherichia coli strains for poly(3-hydroxypropionate) production .PLoS One .2014 ,9 (5):e97845

(33) Genetic analysis of riboswitch-mediated transcriptional regulation responding to Mn2+ in Salmonella .J Biol Chem .2014 ,289 (16):11353-66

(34) Production of block copolymer poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with adjustable structure from inexpensive carbon source .ACS Macro Lett .2013 ,2 (11):996-1000

(35) Dissection of malonyl-coenzyme A reductase of Chloroflexus aurantiacus results in enzyme activity improvement .PLoS One .2013 ,8 (9):e75554

(36) Biosynthesis of Poly(3-hydroxypropionate-co-3-hydroxybutyrate) with fully controllable structures from glycerol .Bioresour Technol .2013 ,142 :741-4

(37) Biosynthesis of poly(3-hydroxypropionate) from glycerol by recombinant Escherichia coli .Bioresour Technol .2013 ,131 :548-51

(38) Biosynthetic pathway for poly(3-hydroxypropionate) in recombinant Escherichia coli .J Microbiol .2012 ,50 (4):693-7

(39) Optimization of fatty alcohol biosynthesis pathway for selectively enhanced production of C12/14 and C16/18 fatty alcohols in engineered Escherichia coli .Microb Cell Fact .2012 ,11 :65

(40)赵广. Mg2+ facilitates leader peptide translation to induce riboswitch-mediated transcription termination .EMBO J .2011 ,30 (8):1485-96

(41)赵广. The CpxR/CpxA two-component system upregulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide protamine .J Biol Chem .2010 ,286 (7):5529-39

(42)赵广. A dual-signal regulatory circuit activates transcription of a set of divergent operons in Salmonella typhimurium .P Natl Acad Sci USA .2008 ,105 (52):20924-9