Associate professor, M.D.,Ph.D., young scholar of Shandong University (future plan). Under the guidance of China's renowned reproductive medicine expert, Academician Zi-Jiang Chen, mainly engaged in the precise subtyping and diagnosis of major reproductive endocrine metabolic diseases in women, committed to exploring the interaction of gender-metabolism-immunity-aging in female reproduction. Has published/participated in over 50 SCI papers, applied for 9 patents for inventions, with 3 authorized and 1 successfully transformed, currently responsible for 2 sub-tasks of the national key R&D plan, 2 National Natural Science Foundation project, 1 Shandong provincial key R&D plan, 1 Shandong provincial natural science foundation project, 1 China Postdoctoral special funding project, 1 China Postdoctoral general project, and 2 horizontal research project.

• 2012/09/01-2015/07/01
  Shanghai Jiaotong University
  Obstetrics and Gynecology
  With Certificate of Graduation for Doctorate Study
• 2005/09/01-2012/07/01
  Shandong University
  Clinical Medicine
  Master's degree graduate

1. Female Reproductive Metabolic Diseases

(1) Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming .Cell metabolism .2025

(2) Population-level analyses identify host and environmental variables influencing the vaginal microbiome .Signal Transduction and Targeted Therapy .2025

(3) Maternal adiposity and perinatal and offspring outcomes: an umbrella review .Nature Human Behaviour .2024

(4) THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass .Nature Communications .2023 ,14 (1)

(5) Three-dimensional genome structures of single mammalian sperm .Nature Communications .2025

(6) Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study .Research .2025

(7) Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models .BMC Medicine .2025

(8) DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation .Science China Life Science .2024

(9) Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome. .Science China Life Science .2025

(10) ZP2: the precision regulator of egg coat architecture during fertilization. .Science China Life Science .2024

(11) Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity .Science China Life sciences .2024

(12) snRNA-seq of human ovaries reveals heat shock proteins are associated with obesity related cancer risk .Journal of Translational Medicine .2024

(13) CHK1 controls zygote pronuclear envelope breakdown by regulating F-actin through interacting with MICAL3 .EMBO Reports .2024

(14) Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines .Human Reproduction .2023

(15) Novel WEE2 gene variants identified in patients with fertilization failure and female infertility .Fertility and Sterility .2019 ,111 (3):519

(16) The impact of sleep on in vitro fertilization embryo transfer outcomes: a prospective study .Fertility and Sterility .2023 ,119 (1):47

(17) Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis .Journal of Pineal Research .2019

(18) No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study .Phenomics .2024

(19) Deconvolution at the single-cell level reveals ovarian cell-type-specific transcriptomic changes in PCOS .Reproductive Biology and Endocrinology .2024

(20) Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study .mSphere .2023

(21) Verification of a ZBTB16 variant in polycystic ovary syndrome patients .Reproductive BioMedicine Online .2020

(22) Effect of Maternal Body Mass Index on the Transcriptomic Network of Human First-Trimester Chorionic Villi .Reprodutive Sciences .2023

(23) PCOS-GWAS Susceptibility Variants in THADA, INSR, TOX3, and DENND1A Are Associated With Metabolic Syndrome or Insulin Resistance in Women With PCOS .Frontiers in Endocrinology .2020

(24) Multiomics Analysis Reveals Molecular Abnormalities in Granulosa Cells of Women With Polycystic Ovary Syndrome .Frontiers in Genetics .2021 ,12

(25) Growth Hormone Promotes in vitro Maturation of Human Oocytes .Frontiers in Endocrinology .2019

(26) Mitochondrial DNA variations and risk of incident gestational diabetes mellitus: a nested case-control study. .Acta Diabetologica .2025

(27) Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress .Oxidative Medicine and Cellular Longevity .2021 ,2021

(28) An integrated RNA-Seq and network study reveals that valproate inhibited progesterone production in human granulosa cells .Journal of steroid biochemistry and molecular biology .2021

(29) Role of Androgen Receptor for Reconsidering the "True" Polycystic Ovarian Morphology in PCOS .Scientific reports .2020 ,10 (1)

(30) Variants in the 5'-UTR of APELA gene in women with preeclampsia .Prenatal Diagnosis .2019 ,39 (4):308

(31) Serum asprosin level in different subtypes of polycystic ovary syndrome: a cross-sectional study .Revista Da Associacao Medica Brasileira .2021 ,67 (4):590

(32) 重大生殖疾病的分子机制研究 .《生命科学》 .2017

1. 亲代肥胖暴露影响子代发育异常的机制研究 , 2024/12/01-2027/11/30

2. （包干项目）女性生殖障碍性疾病病因学及精细化诊治研究, 2024/01/01-2026/12/31

3. AOPEP在多囊卵巢综合征胆固醇代谢异常中的作用机制研究, 2023/08/24-2027/12/31

4. 生殖发育与子代健康, 2023/01/01-2025/12/31

5. 低反应人群中单周期连续刺激方案与两个周期拮抗剂刺激方案的母胎健康比较研究, 2022/09/07-2026/10/31

6. 母体内分泌代谢对卵子及胚胎发育编程的影响及其传代效应, 2021/12/30-2024/11/30

7. 生殖健康重大慢病PCOS发病机制和临床研究, 2020/12/01-2023/12/31

8. miR2278/SOD2/TFRC-铁负载/氧化应激正调控网络在多囊卵巢综合征发生发展中作用机制研究, 2020/09/27-2024/12/31

9. GOLGA2在多囊卵巢综合征发病中的作用机制研究, 2019/07/08-2020/12/31

10. 环境遗传交互作用对胚胎发育与妊娠影响的巢式病例-对照研究, 2018/12/26-2021/12/31

11. miRNA23b-27b-24簇在多囊卵巢综合征发病中的分子作用机制与治疗价值, 2018/07/26-2023/12/31

12. 多囊卵巢综合征的发病机制及干预, 2018/04/01-2021/06/30

13. MiR-601/FAM60A在多囊卵巢综合征颗粒细胞超生理分泌AMH中的作用机制研究, 2016/10/29-2019/06/30

14. MiR-601/SIRT1在多囊卵巢综合征高雄激素发生中的作用机制研究, 2016/08/17-2019/12/31