Name:  Deyu Zhu， Ph.D, 

Associate Professor at the Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University

Office: No. 6432 room in Building 6, Baotu Spring Campus, Shandong University

Office Hours: 8:00-17:00 from Monday to Friday

Office Tel:  +86-531-88382092-606

Email  zhudeyu@sdu.edu.cn

EDUCATION

Ph.D    From Sep.2003 to Jul.2006    Ph.D. in Biochemistry and Molecular Biology, Institute

of Biophysics, Chinese Academy of Sciences, China

Master   From Sep.1999 to Jul.2002     M.S. in Pharmaceutical Chemistry, Institute of

Materia Medica, Chinese Academy of Medical

Sciences & Peking Union Medical College, China

Bachelor From Sep.1995 to Jul.1999   B.S. in Pharmacy, School of Pharmacy, Shandong

University , China.

WORK EXPERIENCE

From Apr. 2015 to present  Associate professor, Department of Biochemistry and

Molecular Biology, School of Basic Medical Sciences,

Cheeloo College of Medicine, Shandong University, China

From Sept.2006 to Mar. 2015  Associate professor, School of Life Science, Shandong University

From Mar.2007 to Sept. 2009  Postdoctoral fellow, National Institute of Environmental Health

Sciences (NIEHS), NIH, USA

From Sep.2002 to Aug.2003   Research Assistant, Institute of Biophysics, Chinese Academy of

Sciences, China

RESEARCH INTERSTS

Structural Biology. The major areas of research includes: (1) Structure and function of nucleic acid binding proteins. (2) Studying the basic mechanisms by which the innate immune system detects invasion of microbial pathogens. (3).Structure and function of proteins in the neurodegenerative diseases and drug design.

SELECTED PUBLICATIONS

1. Lv Y, Sun Q, Wang X, Lu Y, Li Y, Yuan H, Zhu J, Zhu D. Highly EfficientPreparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli. Front Microbiol. 2019, 10:2111 (Corresponding author)

2. Gao J, Yao L, Xia T, Liao X, Zhu D, Xiang Y. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048. FASEB J. 2018, 32(4):2036-2045 (Co-corresponding author)

3. Zhu D, Wang L, Shang G, Liu X, Zhu J, Lu D, Wang L, Kan B, Zhang JR, Xiang Y. Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Mol Cell. 2014, 55(6):931-937

4. Shang G, Zhu D¹, Li N, Zhang J, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.  Nat Struct Mol Biol. 2012, 19(7):725-7(Co-first author)

5. Gong Y, Zhu D¹, Ding J, Dou CN, Ren X, Gu L, Jiang T, Wang DC. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 2011, 18(11):1297-9 (Co-first author)