山东大学教师主页朱宏杰首页中文主页

朱宏杰/ 研究员

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-入职时间：2025-07
-所在单位：药学院
-学历：博士研究生毕业
-办公地点：山东大学趵突泉校区/国家大学科技园
-性别：男
-联系方式：
-学位：博士
-职称：研究员
-毕业院校：南京大学
-学科：天然药物化学

个人简介

Biography

山东潍坊人，博士，研究员，山东大学齐鲁青年学者。在J. Am. Chem. Soc.（2篇）、Nat. Commun.、ACS Catal.（2篇）和Org. Lett.等领域权威期刊发表学术论文20余篇，主持国家自然科学基金面上、青年、中国博士后基金、山东省自然科学基金等多项课题。

研究方向

Research Interests

学术洞察

Academic Insights

研究成果

Research Findings

学术平台

论文成果

科研项目

曾获荣誉

Awards And Honors

01

江苏省优秀博士毕业论文
02

南京大学优秀博士毕业论文

教育经历

Education

工作经历

Work experience

2018.09-2021.09

南京大学

药学

理学博士学位
2014.09-2017.06

广东药科大学/中科院昆明植物研究所

中药学

理学硕士学位
2010.09-2014.06

山东农业大学

制药工程

工学学士学位

2021.10-至今

药学院

山东大学

朱宏杰/ 研究员

个人简介

研究方向

活性天然产物发现及生物合成

酶催化的非经典氧化及环构建/编辑

学术洞察

研究成果

论文成果

Chen, L. H., Li, C. F., Li, F., Chen, Z. P., Fang, R. P., Y. Y., Zhu, H. J.* and Ju, J. H.*.Picolinic acid derivatives and biosynthetic pathway from Epicoccum sorghinum SDUF549. Journal of Natural Products, 89:329-335,2026.

Wu, Q. L., Li, F., Peng, M., Chen, Y. Y., Weng, X., Xiao, Z. X., Tian, X. P., Zhu, H. J.* and Ju, J. H.*.Gene cluster directs diversified carbazole biosynthesis via cooperative halogenation, hydroxylation, and methylation. Organic Letters, 27:14046-14051,2025.

Zhu, H. J., Wang, C. H., Li, K. L., Liu, C. Y., Wu, Q. L., Chang, Q. H., Xu, Z. H. M., W. L., F., Shang, Z., Y, Y. M., Igarashi, Y., Peng, M.* and Ju, J. H.*.Enzyme-catalyzed molecular skeletal editing: α-pyrone to furanone. ACS Catalysis, 15:12103-12113,2025.

Peng, M.#, Wu, Q. L.#, Ma, L. L., Z. J., Hou, X. B., Zhu, H. J.* and Ju, J. H.*.Bacterial biosynthesis of nitrile-containing natural products: basis for recognition of diversifed substrates. ACS Catalysis, 14:17780-17793,2024.

Chen, J.#, Zhu, H. J.#, Peng, M.#, S. W., Li, Q. L., Gu, Y. C. and Ju, J. H.*.Flavin-dependent monooxygenase Kmy13 mediates formation of the carbocyclic ansa system during Kendomycin B biosynthesis. Journal of the American Chemical Society, 146:28242-28249,2024.

Salman Khan, S.#, Zhu, H. J.#, Sun, Z. Q., Li, Y. L., Wan, L., R., Guo, Z. K.* and Jiao, R. H.*.Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.. Chinese Journal of Natural Medicines, 21:58-64,2023.

Zhu, H. J.#, Zhang, B.#, Wei, W. Q.#, Liu, S. H., Xiang, L., Zhu, J. P., Jiao, R. H., Igarashi, Y., Bashiri, G., Liang, Y., Tan, R. X. and Ge, H. M.*.AvmM catalyses macrocyclization through dehydration/michael-type addition in alchivemycin A biosynthesis. Nature Communications, 13:4499,2022.

Zhu, H. J., Zhang, B., Wang, L., W., Liu, S. H., Igarashi, Y., Bashiri, G., Tan, R. X.* and Ge, H. M.*.Redox modifications in the biosynthesis of alchivemycin A enable the formation of its key pharmacophore. Journal of the American Chemical Society, 143:4751-4757,2021.

Zhu, H. J.#, Xu, T.#, Yan, Y. M. and Cheng, Y. X.*.Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation. Bioorganic Chemistry, 104:104258,2020.

Zhu, H. J.#, Xu, T.#, Yan, Y. M., Tu, Z. C. and Cheng, Y. X.*.Neolignans and norlignans from insect medicine Polyphaga plancyi and their biological activities. Natural Products and Bioprospecting, 21:51-62,2020.

科研项目

国家自然科学基金-面上项目,2025-08-27,2029-12-31

中国博士后科学基金-面上项目（一等资助）

山东省自然科学基金-青年基金

国家自然科学基金-青年基金

山东省博士后创新专项（一等资助）

曾获荣誉

江苏省优秀博士毕业论文

南京大学优秀博士毕业论文

教育教学

教育经历

工作经历

var _tsites_com_view_mode_type_=8;朱宏杰/ 研究员

个人简介

研究方向

活性天然产物发现及生物合成

酶催化的非经典氧化及环构建/编辑

学术洞察

研究成果

论文成果

Chen, L. H., Li, C. F., Li, F., Chen, Z. P., Fang, R. P., Y. Y., Zhu, H. J.* and Ju, J. H.*.Picolinic acid derivatives and biosynthetic pathway from Epicoccum sorghinum SDUF549. Journal of Natural Products, 89:329-335,2026.

Wu, Q. L., Li, F., Peng, M., Chen, Y. Y., Weng, X., Xiao, Z. X., Tian, X. P., Zhu, H. J.* and Ju, J. H.*.Gene cluster directs diversified carbazole biosynthesis via cooperative halogenation, hydroxylation, and methylation. Organic Letters, 27:14046-14051,2025.

Zhu, H. J., Wang, C. H., Li, K. L., Liu, C. Y., Wu, Q. L., Chang, Q. H., Xu, Z. H. M., W. L., F., Shang, Z., Y, Y. M., Igarashi, Y., Peng, M.* and Ju, J. H.*.Enzyme-catalyzed molecular skeletal editing: α-pyrone to furanone. ACS Catalysis, 15:12103-12113,2025.

Peng, M.#, Wu, Q. L.#, Ma, L. L., Z. J., Hou, X. B., Zhu, H. J.* and Ju, J. H.*.Bacterial biosynthesis of nitrile-containing natural products: basis for recognition of diversifed substrates. ACS Catalysis, 14:17780-17793,2024.

Chen, J.#, Zhu, H. J.#, Peng, M.#, S. W., Li, Q. L., Gu, Y. C. and Ju, J. H.*.Flavin-dependent monooxygenase Kmy13 mediates formation of the carbocyclic ansa system during Kendomycin B biosynthesis. Journal of the American Chemical Society, 146:28242-28249,2024.

Salman Khan, S.#, Zhu, H. J.#, Sun, Z. Q., Li, Y. L., Wan, L., R., Guo, Z. K.* and Jiao, R. H.*.Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.. Chinese Journal of Natural Medicines, 21:58-64,2023.

Zhu, H. J.#, Zhang, B.#, Wei, W. Q.#, Liu, S. H., Xiang, L., Zhu, J. P., Jiao, R. H., Igarashi, Y., Bashiri, G., Liang, Y.*, Tan, R. X.* and Ge, H. M.*.AvmM catalyses macrocyclization through dehydration/michael-type addition in alchivemycin A biosynthesis. Nature Communications, 13:4499,2022.

Zhu, H. J., Zhang, B., Wang, L., W., Liu, S. H., Igarashi, Y., Bashiri, G., Tan, R. X.* and Ge, H. M.*.Redox modifications in the biosynthesis of alchivemycin A enable the formation of its key pharmacophore. Journal of the American Chemical Society, 143:4751-4757,2021.

Zhu, H. J.#, Xu, T.#, Yan, Y. M. and Cheng, Y. X.*.Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation. Bioorganic Chemistry, 104:104258,2020.

Zhu, H. J.#, Xu, T.#, Yan, Y. M., Tu, Z. C. and Cheng, Y. X.*.Neolignans and norlignans from insect medicine Polyphaga plancyi and their biological activities. Natural Products and Bioprospecting, 21:51-62,2020.

科研项目

国家自然科学基金-面上项目,2025-08-27,2029-12-31

中国博士后科学基金-面上项目（一等资助）

山东省自然科学基金-青年基金

国家自然科学基金-青年基金

山东省博士后创新专项（一等资助）

曾获荣誉

江苏省优秀博士毕业论文

南京大学优秀博士毕业论文

教育教学

教育经历

工作经历

朱宏杰/ 研究员

Zhu, H. J.#, Zhang, B.#, Wei, W. Q.#, Liu, S. H., Xiang, L., Zhu, J. P., Jiao, R. H., Igarashi, Y., Bashiri, G., Liang, Y., Tan, R. X. and Ge, H. M.*.AvmM catalyses macrocyclization through dehydration/michael-type addition in alchivemycin A biosynthesis. Nature Communications, 13:4499,2022.