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研究领域

活性天然产物发现及生物合成，尤其是黄素依赖型氧化酶等介导的非经典氧化及环构建/编辑。

论文成果

1. Chen, L. H., Li, C. F., Li, F., Chen, Z. P., Fang, R. P., Y. Y., Zhu, H. J.* and Ju, J. H.*.Picolinic acid derivatives and biosynthetic pathway from Epicoccum sorghinum SDUF549. Journal of Natural Products, 89:329-335,2026.
2. Wu, Q. L., Li, F., Peng, M., Chen, Y. Y., Weng, X., Xiao, Z. X., Tian, X. P., Zhu, H. J.* and Ju, J. H.*.Gene cluster directs diversified carbazole biosynthesis via cooperative halogenation, hydroxylation, and methylation. Organic Letters, 27:14046-14051,2025.
3. Zhu, H. J., Wang, C. H., Li, K. L., Liu, C. Y., Wu, Q. L., Chang, Q. H., Xu, Z. H. M., W. L., F., Shang, Z., Y, Y. M., Igarashi, Y., Peng, M.* and Ju, J. H.*.Enzyme-catalyzed molecular skeletal editing: α-pyrone to furanone. ACS Catalysis, 15:12103-12113,2025.
4. Peng, M.#, Wu, Q. L.#, Ma, L. L., Z. J., Hou, X. B., Zhu, H. J.* and Ju, J. H.*.Bacterial biosynthesis of nitrile-containing natural products: basis for recognition of diversifed substrates. ACS Catalysis, 14:17780-17793,2024.
5. Chen, J.#, Zhu, H. J.#, Peng, M.#, S. W., Li, Q. L., Gu, Y. C. and Ju, J. H.*.Flavin-dependent monooxygenase Kmy13 mediates formation of the carbocyclic ansa system during Kendomycin B biosynthesis. Journal of the American Chemical Society, 146:28242-28249,2024.
6. Salman Khan, S.#, Zhu, H. J.#, Sun, Z. Q., Li, Y. L., Wan, L., R., Guo, Z. K.* and Jiao, R. H.*.Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.. Chinese Journal of Natural Medicines, 21:58-64,2023.
7. Zhu, H. J.#, Zhang, B.#, Wei, W. Q.#, Liu, S. H., Xiang, L., Zhu, J. P., Jiao, R. H., Igarashi, Y., Bashiri, G., Liang, Y.*, Tan, R. X.* and Ge, H. M.*.AvmM catalyses macrocyclization through dehydration/michael-type addition in alchivemycin A biosynthesis. Nature Communications, 13:4499,2022.
8. Zhu, H. J., Zhang, B., Wang, L., W., Liu, S. H., Igarashi, Y., Bashiri, G., Tan, R. X.* and Ge, H. M.*.Redox modifications in the biosynthesis of alchivemycin A enable the formation of its key pharmacophore. Journal of the American Chemical Society, 143:4751-4757,2021.
9. Zhu, H. J.#, Xu, T.#, Yan, Y. M. and Cheng, Y. X.*.Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation. Bioorganic Chemistry, 104:104258,2020.
10. Zhu, H. J.#, Xu, T.#, Yan, Y. M., Tu, Z. C. and Cheng, Y. X.*.Neolignans and norlignans from insect medicine Polyphaga plancyi and their biological activities. Natural Products and Bioprospecting, 21:51-62,2020.

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