Biography

Xiao Chen is a Professor of the Laboratory of Marine Protozoan Biodiversity & Evolution, affiliated with Marine College at Shandong University. His group aims to delineate mechanisms underlying chromatin regulation and genome evolution using eukaryotic cell models.

Dr. Chen has been focusing on the epigenetic regulation mechanism of cellular homeostasis maintenance using eukaryotic models including ciliate. The findings are highlighted as follows: 

1) Clarified the gene transcription pattern and omics basis for maintaining cellular homeostasis under environmental stress, laying the foundation for further exploration of its epigenetic regulation mechanism; 

2) Elucidated the molecular mechanisms by which epigenetic factors alter gene transcription levels and regulate cellular homeostasis, expanding our understanding of the involvement of epigenetic factors in regulating cellular homeostasis; 

3) Revealed the pathogenic mechanism of cellular homeostasis imbalance caused by chromatin dysregulation and confirmed the potential diagnostic and therapeutic value of epigenetic regulation of cellular homeostasis. 

These findings have led to more than 40 publications in high-impact journals including Nature Communications, PNAS, and Molecular Cell. Dr. Chen's work was highly recognized by distinguished experts in chromatin fields as "a crucial discovery that will provide key information for current and future drug development" and "an important study that further illuminates on the role oncohistones have in gene transcription regulation". 

Currently, the research on the dysregulation of gene transcription by chromatin states has been hampered by a lack of rationalized systems to dig deep into the underlying mechanism. Dr. Chen hereby aims to further explore the roles of histone modifications in regulating gene transcription and maintaining cell physiological and structural stability, in response to the key question of how unicellular eukaryotes maintain cellular homeostasis.


Profile: https://faculty.sdu.edu.cn/xc/en

Chen Lab: https://faculty.sdu.edu.cn/chenlab/en


Education
  • 2016/10/01-2017/09/30
    University of Michigan
    Medical School
    Visiting scholar
  • 2012/09/01-2018/01/01
    Ocean University of China
    Hydrobiology
    Doctoral Degree
  • 2008/09/01-2012/07/01
    Ocean University of China
    Life Science
    Bachelor
Professional Experience
  • 2024-01 — Now
    Shandong University, Marine College
    Professor (Distinguished)
  • 2022-01 — 2023-12
    Shandong University, Marine College
    Professor (Qilu Young Scholar)
  • 2021-04 — 2021-09
    Columbia University, Dept. of Genet. & Dev.
    Associate Research Scientist
  • 2018-04 — 2021-04
    Columbia University, Dept. of Genet. & Dev.
    Postdoctoral Research Scientist
Publication
Research direction

1. Epigenetic Regulation of Homeostasis in Eukaryotes

2. Genome and Chromosome Evolution of Eukaryotes

3. Medical Applications of Systems Biology

Papers

(1) Comprehensive genome annotation of the model ciliate Tetrahymena thermophila by in-depth epigenetic and transcriptomic profiling .Nucleic Acids Research .2024

(2) Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma .Nature Communications .2023

(3) New evidence of consistency between phylogeny and morphology for two taxa in ciliated protists, the subclasses Oligotrichia and Choreotrichia (Protista, Ciliophora) .Molecular Phylogenetics and Evolution .2023

(4) Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas .Molecular Cell .2022

(5) Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation .PNAS .2021

(6) Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors .Molecular Ecology Resources .2019

(7) GPSit: an automated method for evolutionary analysis of nonculturable ciliated microeukaryotes .Molecular Ecology Resources .2018

(8) N6-adenine DNA methylation is associated with H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena .Nucleic Acids Research .2017

(9) Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila .Science China Life Sciences .2016

(10) Phylogenomics of non-model ciliates based on transcriptomic analyses .Protein & Cell .2015

Student Information
  • Yang, Juan  2024/05/01 Hits:[] Times
  • Li, Chenyi  2024/05/01 Hits:[] Times
  • Li, Lu  2024/05/01 Hits:[] Times
  • Yang, Lei  2024/05/01 Hits:[] Times
  • Zhang, Ning  2024/09/08 Hits:[] Times
  • Wei, Deyu  2023/09/23 Hits:[] Times
  • Zhang, Fengming  2024/09/08 Hits:[] Times
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