-
论文名称：
The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response
-
发表刊物：
PLoS Genetics
-
摘要：
Dysregulation of collagen production and secretion contributes to aging and tissue fibrosis of major organs. How procollagen proteins in the endoplasmic reticulum (ER) route as specialized cargos for secretion remains to be fully elucidated. Here, we report that TMEM39, an ER-localized transmembrane protein, regulates production and secretory cargo trafficking of procollagen. We identify the C. elegans ortholog TMEM-39 from an unbiased RNAi screen and show that deficiency of tmem-39 leads to striking defects in cuticle collagen production and constitutively high ER stress response. RNAi knockdown of the tmem-39 ortholog in Drosophila causes similar defects in collagen secretion from fat body cells. The cytosolic domain of human TMEM39A binds to Sec23A, a vesicle coat protein that drives collagen secretion and vesicular trafficking. TMEM-39 regulation of collagen secretion is independent of ER stress response and autophagy. We propose that the roles of TMEM-39 in collagen secretion and ER homeostasis are likely evolutionarily conserved.
-
第一作者：
张哲*
-
通讯作者：
Dengke Ma*
-
全部作者：
Shuo Luo,Guilherme Oliveira Barbosa,Meirong Bai,Thomas B Kornberg
-
论文类型：
期刊论文
-
论文编号：
1
-
影响因子：
5.54
-
DOI码：
10.1371/journal.pgen.1009317
-
是否译文：
否
-
发表时间：
2021-02
-
收录刊物：
SCI
-
发布期刊链接：
-
发布时间：
2021-02-01
En
