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论文名称：
Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking
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发表刊物：
Science Advances
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摘要：
Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathological tissue fibrosis in major organs. How premature collagen proteins in the endoplasmic reticulum (ER) assemble and route for secretion remains molecularly undefined. From an RNA interference screen, we identified an uncharacterized Caenorhabditis elegans gene tmem-131, deficiency of which impairs collagen production and activates ER stress response. We find that amino termini of human TMEM131 contain bacterial PapD chaperone–like domains, which recruit premature collagen monomers for proper assembly and secretion. Carboxy termini of TMEM131 interact with TRAPPC8, a component of the TRAPP tethering complex, to drive collagen cargo trafficking from ER to the Golgi. We provide evidence that previously undescribed roles of TMEM131 in collagen recruitment and secretion are evolutionarily conserved in C. elegans, Drosophila, and humans.
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第一作者：
张哲
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通讯作者：
Dengke K Ma*
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全部作者：
Meirong Bai,Guilherme Oliveira Barbosa,Yuehua Wei,Andrew Chen,Shuo Luo,Xin Wang,Bingying Wang,Tatsuya Tsukui,Hao Li,Dean Sheppard,Thomas B Kornberg
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论文类型：
期刊论文
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论文编号：
2
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影响因子：
13.12
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DOI码：
10.1126/sciadv.aay7667
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是否译文：
否
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发表时间：
2020-02
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收录刊物：
SCI
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发布时间：
2020-02-01
En
