|
个人信息Personal Information
教授 博士生导师 硕士生导师
任职 : Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), 赣南医学院学报, 中国生物工程杂志，解剖科学进展
性别：男
毕业院校：清华大学
学历：研究生(博士)毕业
学位：博士生
在职信息：在职
所在单位：基础医学院
入职时间：2021-01-27
学科：遗传学
发育生物学
生物化学与分子生物学
办公地点：山东大学趵突泉校区电镜楼209
联系方式：zhezhang@sdu.edu.cn 课题组常年招聘助理教授，博士后；并欢迎博士生，硕士生，本科生报考和实习。
Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking
点击次数：
发表刊物：Science Advances
摘要：Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathological tissue fibrosis in major organs. How premature collagen proteins in the endoplasmic reticulum (ER) assemble and route for secretion remains molecularly undefined. From an RNA interference screen, we identified an uncharacterized Caenorhabditis elegans gene tmem-131, deficiency of which impairs collagen production and activates ER stress response. We find that amino termini of human TMEM131 contain bacterial PapD chaperone–like domains, which recruit premature collagen monomers for proper assembly and secretion. Carboxy termini of TMEM131 interact with TRAPPC8, a component of the TRAPP tethering complex, to drive collagen cargo trafficking from ER to the Golgi. We provide evidence that previously undescribed roles of TMEM131 in collagen recruitment and secretion are evolutionarily conserved in C. elegans, Drosophila, and humans.
全部作者：Meirong Bai,Guilherme Oliveira Barbosa,Yuehua Wei,Andrew Chen,Shuo Luo,Xin Wang,Bingying Wang,Tatsuya Tsukui,Hao Li,Dean Sheppard,Thomas B Kornberg
第一作者：张哲
论文类型：期刊论文
通讯作者：Dengke K Ma*
论文编号：2
是否译文：否
发表时间：2020-02-01
收录刊物：SCI