本课题组长期聚焦于环境与职业暴露引起的健康效应及其潜在分子机制。以“暴露-机制-疾病”为主线，重点开展以下三个方向的研究: 

1. 环境毒理与基因组稳定性调控; 

2. 肝脏代谢性疾病的致病机理; 

3. 消化道肿瘤发生机制与转化干预。 

1.  Wang C^*, Lu Q^*, Cao L, Zeng S, Gao Z, Yang Y, Liu X, Gao S, Dong C. The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage. Cell Death & Disease, 2026. Online. https://www.nature.com/articles/s41419-026-08616-1.   (1区, 影响因子12.2)

2.  Cao L^*，Gao S^*，Dong C. The emerging role of DYRK-mediated DNA damage response in cancer. Genes & Diseases，2026，https://doi.org/10.1016/j.gendis.2026.102133. (1区, 影响因子14.6)

3.  Su R, Wen W, Jin Y, Cao Z, Feng Z, Chen J, Lu Y, Zhou G, Dong C, Gao S, Li X, Zhang H, Chao K, Lan P, Wu X, Philips A, Li K, Gao X, Zhang F, Zuo T. Dietary whey protein protects against Crohn's disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome. Gut. 2025 Mar 23:gutjnl-2024-334516. doi: 10.1136/gutjnl-2024-334516. Epub ahead of print. PMID: 40122597. (1区, 影响因子24.6)

4.  Kim JE, Pan X, Tse KY, Chan HH, Dong C, Huen MSY. PHF8 facilitates transcription recovery following DNA double-strand break repair. Nucleic Acids Res. 2024 Sep 23;52(17):10297-10310. doi: 10.1093/nar/gkae661. PMID: 39087553; PMCID: PMC11417394. (1区, 影响因子13.1)

3.  Su B, Lim D, Qi C, Zhang Z, Wang J, Zhang F, Dong C*, Feng Z*. VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU. Cell Death Dis. 2023 Feb 13;14(2):114. doi: 10.1038/s41419-023-05649-8. PMID: 36781846; PMCID: PMC9925808.

4.  Chao Dong, Liwei An, Cheng-han Yu, Michael S.Y. Huen et al. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PMID: 33469661; PMCID: PMC7897492. 

5.  Chao Dong, Kirk L. West, Xin Yi Tan, Junshi Li, Toyotaka Ishibashi, Cheng-han Yu, Shirley M.H. Sy, Justin W.C. Leung, Michael S.Y. Huen. Screen Identifies DYRK1B Network as Mediator of Transcription Repression on Damaged Chromatin. PNAS. 2020;117(29):17019-17030. doi:10.1073/pnas.2002193117.

6.  An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MS. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. PNAS. 2018; 115(35): E8286-8295.

7. Roewenstrunk J, Di Vona C, Chen J, Borras E, Chao D, Arato K, Sabido E, Huen MS, de la Luna S. A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response. Sci Rep 2019; 9(1): 6014.