主要从事环境电离辐射等有害因素所致DNA损伤应答与基因组稳定性调控机制的研究，致力于筛选、鉴定参与辐射损伤的新型调控因子，阐述其在维护基因组稳定性中的作用，旨在揭示防治辐射损伤的新靶标和新策略。

1. Chen C, Lim D, Cai Z, Zhang F, Liu G, Dong C*, Feng Z*. HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3+CD4+T cells against PAHs carcinogenicity. Food Chem Toxicol. 2023 Apr 12;176:113783. doi: 10.1016/j.fct.2023.113783. Epub ahead of print. PMID: 37059382.2.  (共同通讯)

2. Su B, Lim D, Qi C, Zhang Z, Wang J, Zhang F, Dong C*, Feng Z*. VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU. Cell Death Dis. 2023 Feb 13;14(2):114. doi: 10.1038/s41419-023-05649-8. PMID: 36781846; PMCID: PMC9925808. (共同通讯)

3. Yao Y, Chen C, Cai Z, Liu G, Ding C, Lim D, Chao D*, Feng Z*. Screen identifies fasudil as a radioprotector on human fibroblasts. Toxicol Res (Camb). 2022 Jul 22;11(4):662-672. doi: 10.1093/toxres/tfac042. PMID: 36051660; PMCID: PMC9424713. (共同通讯)

4.  Zhang Y, Lim D, Cai Z, Peng J, Jia B, Chu G, Zhang F, Dong C*, Feng Z*. Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages. Ecotoxicol Environ Saf. 2022 Jun 22;241:113779. doi: 10.1016/j.ecoenv.2022.113779. Epub ahead of print. PMID: 35751934.（共同通讯）

5.  Chao Dong, Liwei An, Cheng-han Yu, Michael S.Y. Huen et al. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PMID: 33469661; PMCID: PMC7897492.

6.  Chao Dong, Kirk L. West, Xin Yi Tan, Junshi Li, Toyotaka Ishibashi, Cheng-han Yu, Shirley M.H. Sy, Justin W.C. Leung, Michael S.Y. Huen. Screen Identifies DYRK1B Network as Mediator of Transcription Repression on Damaged Chromatin. PNAS. 2020;117(29):17019-17030. doi:10.1073/pnas.2002193117.

7.  An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MS. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. PNAS. 2018; 115(35): E8286-8295.

8.  Dong C, Zhang F, Luo Y, Wang H, Zhao X, Guo G, Powell SN, Feng Z. p53 suppresses hyper-recombination by modulating BRCA1 function. DNA Repair 2015 Sep;33:60-9.

9.  Liu G, Lim D, Cai Z, Ding W, Tian Z, Dong C, Zhang F, Guo G, Wang X, Zhou P, Feng Z. The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51. Front Oncol. 2021 Mar 25;11:646256. doi: 10.3389/fonc.2021.646256. PMID: 33842359; PMCID: PMC8029989.

10.  Cai Z, Lim D, Liu G, Jin L, Duan W, Ding C, Sun Q, Peng J, Dong C, Zhang F, Feng Z. Valproic acid-like compounds enhance and prolong the radiotherapy effect on breast cancer by activating and maintaining anti-tumor immune function. Front. Immunol. doi: 10.3389/fimmu.2021.646384

11.  Roewenstrunk J, Di Vona C, Chen J, Borras E, Chao D, Arato K, Sabido E, Huen MS, de la Luna S. A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response. Sci Rep 2019; 9(1): 6014.

12. Luo Y, Wang H, Zhao X, Dong C, Zhang F, Guo G, Guo G, Wang X, Powell SN, Feng Z, Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway. Toxicol Res. 2016 Feb 18;5(3):859-870.

13. Peng J, Cai Z, Zhao R, Chen J, Liu G, Dong C, Lim D, Feng Z. The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs. Toxicol Res (Camb). 2020 Aug 31;9(5):609-621. doi: 10.1093/toxres/tfaa069. PMID: 33178421; PMCID: PMC7640934.