本课题组长期聚焦于环境与职业暴露引起的健康效应及其潜在分子机制。我们以“暴露-机制-疾病”为主线，重点开展以下三个方向的研究: 1. 环境毒理与基因组稳定性调控; 2. 消化系统代谢性疾病的致病机理; 3. 消化道肿瘤发生机制与转化干预。 

1.  Wang C^*, Lu Q^*, Cao L, Zeng S, Gao Z, Yang Y, Liu X, Gao S, Dong C. The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage. Cell Death & Disease, 2026. Online. https://www.nature.com/articles/s41419-026-08616-1.   (新锐期刊1区Top, 5年影响因子9.8)

2.  Cao L^*，Gao S^*，Dong C. The emerging role of DYRK-mediated DNA damage response in cancer. Genes & Diseases，2026，https://doi.org/10.1016/j.gendis.2026.102133. (新锐期刊1区, 影响因子9.4)

3.  Su R, Wen W, Jin Y, Cao Z, Feng Z, Chen J, Lu Y, Zhou G, Dong C, Gao S, Li X, Zhang H, Chao K, Lan P, Wu X, Philips A, Li K, Gao X, Zhang F, Zuo T. Dietary whey protein protects against Crohn's disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome. Gut. 2025 Mar 23:gutjnl-2024-334516. doi: 10.1136/gutjnl-2024-334516. Epub ahead of print. PMID: 40122597.

4.  Kim JE, Pan X, Tse KY, Chan HH, Dong C, Huen MSY. PHF8 facilitates transcription recovery following DNA double-strand break repair. Nucleic Acids Res. 2024 Sep 23;52(17):10297-10310. doi: 10.1093/nar/gkae661. PMID: 39087553; PMCID: PMC11417394.

5.  Chao Dong, Liwei An, Cheng-han Yu, Michael S.Y. Huen et al. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PMID: 33469661; PMCID: PMC7897492. 

6.  Chao Dong, Kirk L. West, Xin Yi Tan, Junshi Li, Toyotaka Ishibashi, Cheng-han Yu, Shirley M.H. Sy, Justin W.C. Leung, Michael S.Y. Huen. Screen Identifies DYRK1B Network as Mediator of Transcription Repression on Damaged Chromatin. Proc Natl Acad Sci U S A (PNAS). 2020;117(29):17019-17030. doi:10.1073/pnas.2002193117.

7.  An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MS. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. PNAS. 2018; 115(35): E8286-8295.

8.  Su B, Lim D, Qi C, Zhang Z, Wang J, Zhang F, Dong C*, Feng Z*. VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU. Cell Death Dis. 2023 Feb 13;14(2):114. doi: 10.1038/s41419-023-05649-8. PMID: 36781846; PMCID: PMC9925808.

9.  Chen C, Lim D, Cai Z, Zhang F, Liu G, Dong C*, Feng Z*. HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3+CD4+T cells against PAHs carcinogenicity. Food Chem Toxicol. 2023 Jun;176:113783. doi: 10.1016/j.fct.2023.113783. Epub 2023 Apr 12. PMID: 37059382.

10. Yao Y, Chen C, Cai Z, Liu G, Ding C, Lim D, Chao D*, Feng Z*. Screen identifies fasudil as a radioprotector on human fibroblasts. Toxicol Res (Camb). 2022 Jul 22;11(4):662-672. doi: 10.1093/toxres/tfac042. PMID: 36051660; PMCID: PMC9424713.

11. Zhang Y, Lim D, Cai Z, Peng J, Jia B, Chu G, Zhang F, Dong C*, Feng Z*. Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages. Ecotoxicol Environ Saf. 2022 Jun 22;241:113779. doi: 10.1016/j.ecoenv.2022.113779. Epub ahead of print. PMID: 35751934.

12. Dong C, Zhang F, Luo Y, Wang H, Zhao X, Guo G, Powell SN, Feng Z. p53 suppresses hyper-recombination by modulating BRCA1 function. DNA Repair 2015 Sep;33:60-9.

13. Cai Z, Lim D, Liu G, Jin L, Duan W, Ding C, Sun Q, Peng J, Dong C, Zhang F, Feng Z. Valproic acid-like compounds enhance and prolong the radiotherapy effect on breast cancer by activating and maintaining anti-tumor immune function. Front. Immunol. doi: 10.3389/fimmu.2021.646384  

14. Roewenstrunk J, Di Vona C, Chen J, Borras E, Chao D, Arato K, Sabido E, Huen MS, de la Luna S. A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response. Sci Rep 2019; 9(1): 6014.    

     15. 王晨悦, 高杉杉, 曹连宝, 董超*. DNA双链断裂诱导转录抑制调节蛋白在肿瘤发生和治疗中的研究进展[J]. 中华肿瘤防治杂志, 2025, 32(4): 242-251.DOI: 10.16073/j.cnki.cjcpt.2025.04.07