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  • 郭欣 ( 副教授 )

    个人主页 http://faculty.sdu.edu.cn/guoxin/zh_CN/index.htm

  •   副教授   硕士生导师
个人简介

郭欣,副教授、硕士生导师、山东大学未来学者、美国注册营养师


一、研究领域:

     营养相关疾病-糖尿病和非酒精性脂肪性肝病的分子机制及干预研究。

     分子营养团队:https://faculty.sdu.edu.cn/shandongdaxuefenziyingyangyanjiutuandui/zh_CN/index.htm


二、学术兼职:

1. 第一届营养科学研究专业委员会常务委员

2. 第一届海峡两岸医药卫生交流协会营养健康与食品安全分会委员

3. 中国抗癌协会肿瘤营养专业委员会营养预防组学委员

4. 中华医学会结核病学分会第十七届委员会营养专业委员会委员

5. SCI杂志审稿人:Journal of Nutritional Biochemistry、Journal of Translational Medicine、Molecular Nutrition & Food Research、Frontiers in Pharmacology


三、工作经历

1. 2021.09-至今,山东大学公共卫生学院营养与食品卫生专业,副教授

2. 2017.09 - 2020.11,山东大学公共卫生学院营养与食品卫生专业,副研究员

3. 2016.03 - 2017.08,美国贝勒医学院儿童营养研究中心,助理研究员

4. 2013.07 - 2016.03,美国德克萨斯州A&M大学营养与食品科学系,博士后

5. 2012.08 - 2013.05,美国德克萨斯州A&M大学营养师实习生

     轮转部门包括:Veteran Affair Hospital (wound care, outpatient, food services), Scott & White Hospital (diagnostic medicine,endocrinology and pediatric), St Joseph Hospital (oncology, cardiology, CCU, and nutrition support), Liberty Dialysis, College Station Independent School District, Franklin Independent School District, AgriLife Extension, TAMU Athletics, and Brazos Valley Women, Infants and Children (WIC).


四、教育经历

1. 2007.09 - 2013.05,美国德克萨斯州A&M大学,营养学,博士

2. 2004.09 - 2007.06,中国科学技术大学,生物化学与分子生物学,硕士

3. 2000.09 - 2004.06,江西师范大学,生物工程,学士


五、科研论文

1.      Guo, X.*#, Zheng, J.*, Zhang, S., Jiang, X., Chen, T., Yu, J., Wang, S., Ma, X., Wu, C#. Advances in unhealthy nutrition and circadian dysregulation in pathophysiology of NAFLD. Frontiers in Clinical Diabetes and Healthcare. 2021, 2:691828.

2.       Jiang, X., Zhang, Y., Hu, W., Liang Y., Zheng L, Zheng, J., Wang, B. #, Guo, X#. Different effects of leucine supplementation and/or exercise on systemic insulin sensitivity in mice. Frontiers in Endocrinology. 2021, 12: 651303.

3.       Zhu, BL.*, Guo, X.*, Xu, H.*, Jiang, BX., Li, HG., Wang, YN., Yin, QL., Zhou, TH., Cai, JJ., Glaser, S., Meng, FY., Francis, H., Alpini, G., Wu, C. Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells. Laboratory Investigation. 2021, 101: 328–340.

4.       Guo,X., Zhu, B., Xu, H., Li. H., Jiang, B., Wang, Y., Zheng, B., Glaser, S., Alpini, G., Wu, C. Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation. Liver Research. 2020,4: 136-144.

5.       Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C#., Guo,X#. Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD. Frontiers in Medicine. 2020, 7: 361.

6.       Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, SL., Pei, Y., Knight, L., Deveau, M., Chen, Y., Qian, X., Xiao, X., Li, Q., Chen, X., Huo, Y., McDaniel, K., Francis, H., Glaser, S., Meng, F., Alpini, G., Wu, C. Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. Gastroenterology. 2018,155(6)1971. DOI: 10.1053/j.gastro.2018.09.010.

7.       Suo, J.N., Zhao, XZ., Guo, X.,# Zhao, XL#. Met-enkephalin improves metabolic syndrome in high fat diet challenged mice through promotion of adipose tissue browning. Toxicology and Applied Pharmacology, 2018. 359: p. 12-23.

8.       Guo, X.*, Shu, C.*, Li, H., Pei, Y., Woo, S., Zheng, J., Xu, H., Botchlett, R., Qi, T., Guo, T., Zhao, J., Cai, Y., Hu, X., Zhao, Y., Huo, Y., Li, P., Wu, C. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation.  Scientific Report. 2017, 7(1): 6355.

9.       Mo, Q., Salley, J., Roshan, T., Baer, L., May, F., Jaehning, E., Lehing, A., Guo, X., Tong, Q., Nuotio-Antar, A., Shamsi, F., Tseng, Y., Stanford, K., Chen, M. Identification and characterization of a supraclavicular brown adipose tissue in mice. Journal of Clinical Investigation Insight. 2017, 2(11): e93166. 

10.       Botchlett, R., Woo, S., Liu, M., Pei, Y., Guo, X., Li, H., Wu, C. Nutritional approaches for managing obesity-associated metabolic diseases. Journal of Endocrinology. 2017, 233 (3) : R145-R171.

11.    Botchlett, R., Li, H., Guo, X., Qi, T., Zhao, J.,  Zheng, J., Woo, S., Pei, Y., Liu, M., Hu, X., Chen, G.,  Guo, T., Li, Q., Xiao, X., Huo, Y., and Wu, C. Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells. Scientific Report. 2016, 6 :28963.

12.    Guo, T., Woo, S., Guo, X., Li, H., Zheng, J., Botchlett, R., Liu, M., Pei, Y., Xu, H., Cai, Y., Li. X., Li, Q., Xiao, X., Huo, Y., and Wu, C. Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity. Scientific Report, 2016, 6:22612.

13.    Xu, H., Li, H., Woo, S., Kim, S., Shende, V. R., Neuendorff, N., Guo, X., Guo, T., Qi, T., Pei, Y., Zhao, Y., Hu, X., Zhao, J., Chen, L., Chen, L., Ji, J., Alaniz, R.C., Earnest, D.J., Wu, C. Myeloid cell-specific disruption of Period 1 and Period 2 exacerbates diet-induced inflammation and insulin resistance. J Biol Chem, 2014; 289 (23): 16374-16388.

14.    Xu, Y., An, X., Guo, X., Habtetsion, T., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R., Fulton, D., Su, Y., Hoda, M. N., Zhou, G., Wu, C., Huo, Y. Endothelial PFKFB3 plays a critical role in angiogenesis. ATVB, 2014; 34 (6): 1231-1239.

15.    Woo, S., Xu, H., Li, H., Zhao, Y., Hu, X., Zhao, J., Guo, X., Guo, T., Botchlett, R., Qi, T., Huo, Y., Wu, C. Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in Diet-Induced Obesity. PLoS ONE, 2014; 9 (3), e91111.

16.    Chen, Y., Mu, P., He, S., Tang, X., Guo, X., Li, H., Xu, H., Woo, S., Qian, X., Zeng, L., Wu C. Gly482Ser mutation impairs the effects of peroxisome proliferator–activated receptor γ coactivator-1α on decreasing fat deposition and stimulating phosphoenolpyruvate carboxykinase expression in hepatocytes. Nutrition Research. 2013; 33 (4): 332-339.

17.    Li, H.*, Guo, X.* , Xu, H., Woo, S., Halim V., Morgan C., Wu, C. A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis. J Nutr Biochem. 2013; 24 (6): 1153-1158.

18.    Guo, X., Li, H., Xu, H., Halim, V., Thomas, L.N., Woo, S., Huo, Y., Chen, Y. U., Sturino, J.M., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine inflammatory response. J Nutr Biochem, 2013; 24 (5): 770-775.

19.    Guo, X.*, Li, H.*, Xu, H.*, Woo, S., Dong, H., Lu, F., Lange, A.J., Wu, C. Glycolysis in the control of blood glucose homeostasis (Invited Review). Acta Pharmaceutica Sincia, 2012; 2:358-367.

20.    Guo X.*, Li H.*, Xu H., Halim V., Zhang W., Wang H., Ong K.T., Woo S.L., Walzem R.L., Mashek D.G., Dong H., Lu F., Wei L., Huo Y, and Wu C. Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice. PLoS ONE, 2012; 7:e39286. PMCID: PMC3387145.

21.    Huo, Y.*, Guo, X.* , Li, H., Xu, H., Halim, V., Zhang, W., Wang, H., Fan, Y., Ong, K.T., Woo, S., Chapkin, R.S, Mashek,D.G., Chen, Y., Dong, H., Lu, F., Wei, L., Wu. C. Targeted overexpression of inducible 6-Phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory response. J Biol Chem, 2012; 287(25): 21492-21500. 

22.    Zhuang, G.*, Meng, C.* , Guo, X., Xu, H., Wang, G., Li, H., and Wu, C., Zhou, B. A Novel Regulator of Macrophage Activation miR-223 in Obesity-Associated Adipose Tissue Inflammation. Circulation, 2012; 125(23): 2892–2903.

23.    Guo, X., Huo, Y., Xu, K., Li, H., Zhang, W., Wang, H., Zhang, J., Lange, A.J., Chen, Y.E., and Wu, C. Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of rosiglitazone in mice. J Biol Chem, 2010; 285: 23711-23720.

24.    Huo, Y., Guo, X., Li, H., Wang, H., Zhang, W., Wang, Y., Zhou, H., Gao, Z., Telang, S., Chesney, J., Chen, Y.E., Ye, J., Chapkin, R.S., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response. J Biol Chem, 2010; 285: 3713-3721.

25.    Chen, Y.P.*, Shen, Y.Y.*, Guo, X.* , Zhang, C.S., Yang, W.J., Ma, M.L., Liu, S., Zhang, M.B., and Wen, L.P. Transdermal protein delivery by a coadministered peptide identified via phage display. Nature Biotechnology, 2006; 455-460.


六、科研项目

1. 科技部重点研发子项目,2019.06-2022.06,164万元,主持

2. 国家自然基金-青年项目“棕榈油酸通过调控 SIRT3来抑制肝脏糖异生的机制研究”,81803224,2019.01-2021.12,21万元,主持

3. 山东大学青年学者未来计划项目,2018WLJH33,2018.07-2023.06,50万元,主持

4. 山东大学基本科研业务费项目2017TB0028,   2017.09-2019.12, 15万元,主持


七、奖项

1. 山东大学2021年齐鲁医学院青年教师全英文授课比赛一等奖

2. 2020年度山东大学青年教师教学比赛中评为“教学能手”称号

3. 2020年度山东大学青年教师教学比赛二等奖

4. 2019年第一届山东省公共卫生与预防医学青年教师微课比赛一等奖

5. 山东大学2019年MBBS项目青年教师全英文授课比赛三等奖

6. 2018年山东大学公共卫生学院青年教师比赛二等奖

7. Outstanding Graduate Award in Nutrition, Texas A&M University, 2013

8. NFSC Award in Excellence for Graduate Research Assistant, Texas A&M University, 2012


八、教学工作

   主讲中国大学MOOC《饮食营养与健康》(https://www.icourse163.org/course/SDU-1461796178?from=searchPage)、参与讲授《营养与食品卫生学》、《预防医学》、留学生课程《Nutrition》和《Preventive Medicine》;主讲留学生课程《Human Nutrition and Health》;主讲全英文研究生课程《Nutritional Physiological Biochemistry》、《营养与疾病》,参与讲授《Nutrition and Chronic Diseases》、《营养学研究进展》等课程。

教研项目:1. 2020年山东大学研究生国际化课程建设项目-Nutritional Physiological Biochemistry,主持

          2. 2020年山东大学留学生国际化课程建设项目-Human Nutrition and Health,主持

          3. 2019年山东大学教改项目-《饮食营养与健康》在线课程的制作,主持





教育经历
  • [1] 2000.9 -- 2000.6

    江西省吉安市第一中学

  • [2] 2000.9 -- 2004.6

    江西师范大学       生物工程       工学学士学位

  • [3] 2004.9 -- 2007.6

    中国科学技术大学       生物化学和分子生物学       理学硕士学位

  • [4] 2007.9 -- 2013.5

    德克萨斯州农工大学       营养学       哲学博士学位

工作经历
  • [1] 2017.9 -- 至今

    山东大学公共卫生学院      副教授

  • [2] 2016.3 -- 2017.8

    美国贝勒医学院儿童营养研究中心      助理研究员

  • [3] 2013.7 -- 2016.3

    美国得克萨斯州农工大学农学院营养与食品科学系      博士后

社会兼职
  • [1] 2021.6 -- 至今

    第一届营养科学研究专业委员会常务委员

  • [2] 2019.4 -- 至今

    中国抗癌协会肿瘤营养专业委员会营养预防组学委员

  • [3] 2021.4 -- 至今

    中华医学会结核病学分会第十七届委员会营养专业委员会委员

  • [4] 2019.4 -- 至今

    第一届海峡两岸医药卫生交流协会营养健康与食品安全分会委员

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