郭欣，副教授、硕士生导师、美国注册营养师。毕业于美国德克萨斯州A&M大学，获营养学博士学位，曾任美国贝勒医学院助理研究员。主要从事肥胖、糖尿病和非酒精性脂肪肝等营养相关疾病的防治作用及分子机制研究工作。目前担任山东防痨协会营养专业委员会第一届委员会副主任委员、山东营养学会第六届理事会理事、第一届山东营养学会营养科学研究专业委员会常务委员、中华医学会结核病学分会第十八届委员会营养专业委员会委员、济南营养学会第八届理事会理事。在国内外专业学术期刊发表科研论文31篇，其中包括Food Science and Human Wellness、Journal of Agricultural and Food Chemistry、Circulation、Journal of Biological Chemistry （JBC）、Arteriosclerosis Thrombosis and Vascular Biology（ATVB）、Journal of Nutritional Biochemistry、Nature Biotechnology、Gastroenterology等专业领域TOP期刊。

科研项目

1. 山东省自然基金-面上项目“棕榈油酸（C16:1n7）通过降低巨噬细胞中CD36/DHHC6棕榈酰化途径改善肝脏炎症反应和纤维化的机制研究”，ZR2023MH140，2024.01-2026.12，10万元，主持

2. 科技部重点研发子项目，2019.06-2022.06，164万元，主持

3. 国家自然基金-青年项目“棕榈油酸通过调控 SIRT3来抑制肝脏糖异生的机制研究”，81803224，2019.01-2021.12，21万元，主持

4. 国家自然基金-面上项目“多途径特异性调控P53/NRF2抗氧化信号通路对糖尿病肾病的干预研究”，81973031， 2020.01-2023.12，64.4万元，参加

5. 科研院横向，“食品安全跟踪评价与方案改进”，2021.01-2021.12，5万元，主持

6. 山东大学青年学者未来计划项目，2018WLJH33，2018.07-2023.06，50万元，主持

7. 山东省科技厅，“磷脂型DHA/EPA改善脂多糖所致肠道损伤的作用及其机制研究”，LMDBKF-2019-05，2020.04-2022.08，20万元，参加

7. 山东大学基本科研业务费项目2017TB0028, 2017.09-2019.12, 15万元，主持

学术论文

1. Lu, Z., Zhen, Q., Liang, Q., Bian, C., Sun, W., Lv, H., Tian, C., Zhao, X.#, and Guo, X#. Roles of gut microbiota metabolites and circadian genes in the improvement of glucose and lipid metabolism in KKAy mice by theabrownin. Journal of Agricultural and Food Chemistry. 2025. 

2. Zhou, M., Yang, H., Zheng, Y., Wu, Z., Chen, C., Liang, Q., Yang, Y., Wu, H. #, Guo, X. #, Du, L#. Krill oil attenuates obesity-induced skeletal muscle atrophy in mice. Food Science and Human Wellness, 2025, 14(1): 9250018

3. Lu, Z., Zheng, Y., Zheng, J., Liang, Q., Zhen, Q., Cui, M., Yang, H., Wu, H., Tian, C., Zhu, K., Bian, C., Du, L., Wu, H., Guo, X#. Theabrownin from Fu Brick tea ameliorates high-fat induced insulin resistance, hepatic steatosis, and inflammation in mice by altering the composition and metabolites of gut microbiota. Food & Function. 2024, 15: 4421- 4435. 

4. Chen, T.*, Yu, J.*, Guo, X.*, Wang, S., Wang, Z., Chen, Y., Hu, X., Li, L., Chen, L., Zheng, J. ADK inhibits β-cell proliferation and promotes dysregulation of glucose homeostasis. Diabetes Obes Metab. 2024, 26: 2956-2968.

5. Liang, Q., Zheng, Y., Meng, F., Jiang, X., Zhen, Q., Lu, Z., Zhang, S., Du, L., Wu, H. #, Guo, X#. Palmitoleic Acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice. Food Science and Human Wellness. 2024, 13. 

6. Zhen, Q., Liang, Q., Wang, H., Zheng, Y., Lu, Z., Bian, C., Zhao, X. #, Guo, X#. Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice. Frontiers in Endocrinology. 2023, 14: 1118925. 

7. Guo, X. *#, Jiang, X., Chen, K., Liang, Q., Zhang, S., Zheng, J., Ma, X., Jiang, H., Wu, H., Tong, Q#. The role of palmitoleic acid in regulating hepatic gluconeogenesis through SIRT3 in obese mice. Nutrients. 2022, 14(7): 1482. 

8. Du, L., Zheng, Y., Yang, Y., Huang, Y., Hao, Y., Chen, C., Wang, B., Guo, X., Wu, H. #, Su, G#. Krill oil prevents lipopolysaccharide-evoked acute liver injury in mice through inhibition of oxidative stress and inflammation. Food & Function. 2022, 13(7): 3853-3864. 

9. Sun, X., Sun, X., Meng, H., Wu, J., Guo, X., Du, L.#, Wu, H#. Krill oil inhibits NLRP3 inflammasome activation in the prevention of the pathological injuries of diabetic cardiomyopathy. Nutrients. 2022, 14(2): 368. 

10. Yang, C. *, Guo, X. *,  Li, J. *,  Han, J., Jia, L., Wen, H., Sun, C., Wang, X., Zhang, B., Li, J., Chi, Y., An, T.,  Wang, Y., Wang, Z. #, Li, H. #, Li, L#. Significant upregulation of HERV-K (HML-2) transcription levels in human lung cancer and cancer cells. Frontiers in Microbiology. 2022, 13: 850444. 

11. Chen, K., Angulo, A., Guo, X., More, X., Ochsner, S., Lopez1, E., Saul1, D., Pang, W., Sun, Y., McKenna, N. #, Tong, Q#. Adipocyte-specific ablation of PU.1 promotes energy expenditure and ameliorates metabolic syndrome in aging mice. Frontiers in Aging. 2022, 2: 803482.

12. Guo, X.*#, Zheng, J.*, Zhang, S., Jiang, X., Chen, T., Yu, J., Wang, S., Ma, X., Wu, C#. Advances in unhealthy nutrition and circadian dysregulation in pathophysiology of NAFLD. Frontiers in Clinical Diabetes and Healthcare. 2021, 2: 691828.

13. Jiang, X., Zhang, Y., Hu, W., Liang Y., Zheng L, Zheng, J., Wang, B. #, Guo, X#. Different effects of leucine supplementation and/or exercise on systemic insulin sensitivity in mice. Frontiers in Endocrinology. 2021, 12: 651303. 

14. Zhu, BL.*, Guo, X.*, Xu, H.*, Jiang, BX., Li, HG., Wang, YN., Yin, QL., Zhou, TH., Cai, JJ., Glaser, S., Meng, FY., Francis, H., Alpini, G., Wu, C. Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells. Laboratory Investigation. 2021, 101: 328–340. 

15. Guo, X., Zhu, B., Xu, H., Li. H., Jiang, B., Wang, Y., Zheng, B., Glaser, S., Alpini, G., Wu, C. Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation. Liver Research. 2020, 4: 136-144. 

16. Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C#., Guo, X#. Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD. Frontiers in Medicine. 2020, 7: 361. 

17. Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, SL., Pei, Y., Knight, L., Deveau, M., Chen, Y., Qian, X., Xiao, X., Li, Q., Chen, X., Huo, Y., McDaniel, K., Francis, H., Glaser, S., Meng, F., Alpini, G., Wu, C. Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. Gastroenterology. 2018, 155(6): 1971. 

18. Suo, J.N., Zhao, XZ., Guo, X. #, Zhao, XL#. Met-enkephalin improves metabolic syndrome in high fat diet challenged mice through promotion of adipose tissue browning. Toxicology and Applied Pharmacology. 2018, 359: 12-23. 

19. Guo, X.*, Shu, C.*, Li, H., Pei, Y., Woo, S., Zheng, J., Xu, H., Botchlett, R., Qi, T., Guo, T., Zhao, J., Cai, Y., Hu, X., Zhao, Y., Huo, Y., Li, P., Wu, C. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation.  Scientific Report. 2017, 7(1): 6355. 

20. Mo, Q., Salley, J., Roshan, T., Baer, L., May, F., Jaehning, E., Lehing, A., Guo, X., Tong, Q., Nuotio-Antar, A., Shamsi, F., Tseng, Y., Stanford, K., Chen, M. Identification and characterization of a supraclavicular brown adipose tissue in mice. Journal of Clinical Investigation Insight. 2017, 2(11): e93166. 

21. Guo, T., Woo, S., Guo, X., Li, H., Zheng, J., Botchlett, R., Liu, M., Pei, Y., Xu, H., Cai, Y., Li. X., Li, Q., Xiao, X., Huo, Y., and Wu, C. Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity. Scientific Report. 2016, 6:22612. 

22. Xu, Y., An, X., Guo, X., Habtetsion, T., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R., Fulton, D., Su, Y., Hoda, M. N., Zhou, G., Wu, C., Huo, Y. Endothelial PFKFB3 plays a critical role in angiogenesis. ATVB. 2014; 34 (6): 1231-1239. 

23. Li, H.*, Guo, X.*, Xu, H., Woo, S., Halim V., Morgan C., Wu, C. A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis. J Nutr Biochem. 2013, 24 (6): 1153-1158. 

24. Guo, X., Li, H., Xu, H., Halim, V., Thomas, L.N., Woo, S., Huo, Y., Chen, Y. U., Sturino, J.M., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine inflammatory response. J Nutr Biochem. 2013, 24 (5): 770-775. 

25. Guo, X.*, Li, H.*, Xu, H.*, Woo, S., Dong, H., Lu, F., Lange, A.J., Wu, C. Glycolysis in the control of blood glucose homeostasis (Invited Review). Acta Pharmaceutica Sincia. 2012, 2: 358-367.

26. Guo X.*, Li H.*, Xu H., Halim V., Zhang W., Wang H., Ong K.T., Woo S.L., Walzem R.L., Mashek D.G., Dong H., Lu F., Wei L., Huo Y, and Wu C. Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice. PLoS ONE. 2012, 7: e39286. 

27. Huo, Y.*, Guo, X.*, Li, H., Xu, H., Halim, V., Zhang, W., Wang, H., Fan, Y., Ong, K.T., Woo, S., Chapkin, R.S, Mashek,D.G., Chen, Y., Dong, H., Lu, F., Wei, L., Wu. C. Targeted overexpression of inducible 6-Phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory response. J Biol Chem. 2012, 287(25): 21492-21500. 

28. Zhuang, G.*, Meng, C.*, Guo, X., Xu, H., Wang, G., Li, H., and Wu, C., Zhou, B. A Novel Regulator of Macrophage Activation miR-223 in Obesity-Associated Adipose Tissue Inflammation. Circulation. 2012, 125(23): 2892–2903. 

29. Guo, X., Huo, Y., Xu, K., Li, H., Zhang, W., Wang, H., Zhang, J., Lange, A.J., Chen, Y.E., and Wu, C. Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of rosiglitazone in mice. J Biol Chem. 2010, 285: 23711-23720. 

30. Huo, Y., Guo, X., Li, H., Wang, H., Zhang, W., Wang, Y., Zhou, H., Gao, Z., Telang, S., Chesney, J., Chen, Y.E., Ye, J., Chapkin, R.S., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response. J Biol Chem. 2010, 285: 3713-3721. 

31. Chen, Y.P.*, Shen, Y.Y.*, Guo, X.* , Zhang, C.S., Yang, W.J., Ma, M.L., Liu, S., Zhang, M.B., and Wen, L.P. Transdermal protein delivery by a coadministered peptide identified via phage display. Nature Biotechnology. 2006: 455-460.