山东大学教师主页黄伯世 Structure-based Design and Discovery of Pyridyl-bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies Home

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Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Release Time:2022-12-06 Hits:

Journal:Journal of Medicinal Chemistry
Discipline:Medicine
First-Level Discipline:Pharmaceutical Science
Document Type:J
Volume:62
Issue:4
Page Number:2083–2098
Impact Factor:8.039
DOI Number:10.1021/acs.jmedchem.8b01729
Translation or Not:No
Date of Publication:2019-02
Included Journals:SCI

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Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles