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Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Date of Publication:2019-02-01 Hits:

Journal:Journal of Medicinal Chemistry
Indexed by:Journal paper
Discipline:Medicine
First-Level Discipline:Pharmaceutical Science
Document Type:J
Volume:62
Issue:4
Page Number:2083–2098
Translation or Not:no
Date of Publication:2019-02-01
Included Journals:SCI

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Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles