教师简介

Prof. Huo received his B.Sc. degree (2008) at Tianjin University, China. He obtained his M.Sc. degree (2010) and PhD degree (2014) at Saarland University, Germany, under the supervision of Prof. Rolf Müller. Then he joined Prof. Wilfred A. van der Donk's lab for three-year postdoctoral research at University of Illinois at Urbana-Champaign and Howard Hughes Medical Institute, USA. In 2017 he returned to China as a“Qilu”Youth Scholar Professor at Shandong University. His research interests focus on genome mining and genetic engineering of microbial natural products, as well as biochemical studies on interesting biosynthetic tailoring enzymes.


教育经历
  • 2011-1 — 2014-6
    德国萨尔大学
    生物制药工程
    理学博士学位
  • 2008-10 — 2010-11
    萨尔大学
    生物制药工程
    理学硕士学位
  • 2004-9 — 2008-6
    天津大学
    生物工程
    工学学士学位
工作经历
  • 2017-10 — 至今
     山东大学生命科学学院  新药创制党支部书记/院长助理 
    教授
  • 2014-09 — 2017-09
     美国伊利诺伊大学香槟分校 
学术兼职
  • 2020-3 — 至今
    微生物技术国家重点实验室科普专家团
  • 2020-3 — 至今
    青岛海信科学探索中心科普专家团
研究概况

Huo's group research interests focus on genome mining and genetic engineering of microbial natural products, as well as biochemical studies on interesting biosynthetic tailoring enzymes.

研究方向

1.微生物天然产物生物合成

论文成果

(1) Heterologous expression facilitates the discovery and characterization of marine microbial natural products.Engineering Microbiology.2023 (4):100137

(2) Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity.J. AM. CHEM. SOC..2023,145 (30):16924

(3) Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis.ACS Synthetic Biology.2023,12 (4):971-977

(4) 王晓彤.Deciphering the Biosynthesis of Novel Class I Lanthipeptides from Marine Pseudoalteromonas Reveals a Dehydratase PsfB with Dethiolation Activity.ACS Chemical Biology.2023,18 (5):1218

(5) 王会梅.Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171.ACS Chemical Biology.2023

(6) Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity.Journal of the American Chemical Society.2023,145 (30):16924

(7) 王晓彤.Deciphering the Biosynthesis of Novel Class I Lanthipeptides from Marine Pseudoalteromonas Reveals a Dehydratase PsfB with Dethiolation Activity.ACS Chemical Biology.2023 (10.1021/acschembio.3c00135)

(8) Recent advances in discovery, bioengineering and bioactivity-evaluation of ribosomally synthesized and post-translationally modified peptides.ACS BIO&MED CHEM Au.2022 (6)

(9) 霍刘杰.Structure and Activity Relationships of the Two-Component Lantibiotic Bicereucin.ACS INFECTIOUS DISEASES.2022 (12)

(10) 霍刘杰.Uncovering a Subtype of Microviridins via the Biosynthesis Study of FR901451.ACS Chemical Biology.2022 (12)

(11) 王宗杰.Engineering of Burkholderia thailandensis strain E264 serves as a chassis for expression of complex specialized metabolites.Frontiers in Microbiology.2022 (fmicb.2022.1073243)

(12) 钟冠男.In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2'-aminocyclopropyl)alanine biosynthesis.Engineering Microbiology.2021,2 (1):100007

(13) 霍刘杰.Biochemical characterization of a polyethylene terephthalate hydrolase and design of high-throughput screening for its directed evolution.Engineering Microbiology.2022 (2 (2022) 100020)

(14) 申琪瑶.Characterization of a Cryptic NRPS Gene Cluster in Bacillus velezensis FZB42 Reveals a Discrete Oxidase Involved in Multithiazole Biosynthesis.Acs catalysis.2022,12 (6):3371

(15) 霍刘杰.Discovery and Characterization of Marinsedin, a New Class II Lanthipeptide Derived from Marine Bacterium Marinicella sediminis F2(T).ACS Chemical Biology.2022 (10.1021/acschembio.2c00021)

(16) 陈汉娜.Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales.Critical reviews in microbiology.2019,45 (2):162

(17) 王宗杰.Genome Mining and BiosynthesiS of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Organic Letters.2020,22 (3):939

(18) 霍刘杰.Discovery and Characterization of Bicereucin, an Unusual D-Amino Acid-Containing Mixed Two-Component Lantibiotic.Journal of American Chemical Society.2016

(19) 霍刘杰.Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae.Chembiochem.2020,21 (1-2):190

(20) Bobeica, Silvia C..Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.Elife.2019,8

(21) 霍刘杰.Heterologous expression of bacterial natural product biosynthetic pathways.Natural Product Reports.2019,36 (10):1412

(22) 王雪.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America.2018,115 (18):255

(23) 王雪.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America.2018,115 (18):E4255

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授课信息

1. 酶与蛋白质

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