姜新义，教授，博导，国家杰出青年基金获得者，国家高层次青年人才，国家重点研发计划重点项目首席科学家，山东省靶向递药与高端制剂重点实验室主任，山东省高校青创引育团队带头人，山大杰青、齐鲁青年学者，山东大学药学院“智能材料与药物精准递送”团队PI。

先后承担国家基金委原创探索项目、国合重点项目，科技部重点研发计划重点项目，山东省重点、重大项目等；在Nature Cancer，Science Translational Medicine，Nature Nanotechnology，Nature Communications，Science Advances, PNAS等学术期刊上发表论文60余篇；申报国家发明专利 40余项、美国专利3项，20项已获授权，科研成果转化2项（累计2000万元）。应邀在国际控释协会、中国药学大会、生物医学工程BMES等国内外学术会议上做口头报告60余次，国际先进材料协会会士，先后获得国际先进材料协会科学家奖，山东省医学科技二等奖；指导研究生获得教育部“博新”人才计划资助（2人），获得全国药学专业学位研究生优秀学位论文（1人），获得山东省研究生优秀成果一等奖（2人）等。

• 2013/04/02-2017/10/31
  斯坦福大学
  Biomedical Engineering
  Postgraduate (Postdoctoral)
• 2009/09/01-2012/06/26
  复旦大学
  药剂学

• 2017-11 — Now
  齐鲁医学院 药学院山东大学
• 2013-04 — 2017-10
  医学院斯坦福大学

1. 核酸药物递释系统设计及转化应用； 基于纳米医学的重大疾病诊疗新策略； 生物医学工程

(1) Implantable Microneedle-Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse .ADVANCED MATERIALS .2024

(2) mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model .ACS nano .2024 ,18 (3):2261-2278

(3) Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse .NATURE COMMUNICATIONS .2024 ,15 (1)

(4) Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice .Science Advances .2024 ,10 (24)

(5) Intracavitary Spraying of Nanoregulator-Encased Hydrogel Modulates Cholesterol Metabolism of Glioma-Supportive Macrophage for Postoperative Glioblastoma Immunotherapy .ADVANCED MATERIALS .2023

(6) Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice .ADVANCED MATERIALS .2023 ,35 (11)

(7) Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy .SCIENCE TRANSLATIONAL MEDICINE .2022 (14)

(8) Cell membrane derived liposomes loaded with DNase I target neutrophil extracellular traps which inhibits colorectal cancer liver metastases .Journal of Controlled Release .2023 ,357 :620-629

(9) Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice .NATURE COMMUNICATIONS .2023 ,14 (1)

(10) In situ MUC1-specific CAR engineering of tumor-supportive macrophages stimulates tumoricidal immunity against pancreatic adenocarcinoma .NANO TODAY .2023 ,49

(11) Metabolic Modulation of Intracellular Ammonia via Intravesical Instillation of Nanoporter-Encased Hydrogel Eradicates Bladder Carcinoma .Advanced Science .2023 ,10 (12)

(12) Surficial nano-deposition locoregionally yielding bactericidal super CAR-macrophages expedites periprosthetic osseointegration .Science Advances .2023 ,9 (22)

(13) Leveraging tumor cell ferroptosis for colorectal cancer treatment via nanoelicitor-activated tumoricidal immunity .Chemical Engineering Journal .2022 ,430

(14) Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin-Induced Murine Model .ADVANCED MATERIALS .2022 ,34 (14):e2107506

(15) Bioinspired nano-painting on orthopedic implants orchestrates periprosthetic anti-infection and osseointegration in a rat model of arthroplasty .Chemical Engineering Journal .2022 ,435

(16)刘毅. Galectin-1 inhibited LPS-induced autophagy and apoptosis of human periodontal ligament stem cells .Inflammation .2021 ,44 (4):1302

(17)高琼琼. Reply to "Comment on 'In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida Albicans Infection"' .ACS nano .2021 ,15 (3):3544

(18)Abdalla, Mohnad. Progress in research on the S protein as the target of COVID-19 vaccines .EXPERT REVIEW OF VACCINES .2021

(19)张晶. Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection .NATURE NANOTECHNOLOGY .2021

(20)Kong, Degang. Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal .Drug Delivery .2020 ,27 (1):1729

(21)陈晨. In situ tuning proangiogenic factor-mediated immuno-tolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor .THERANOSTICS .2020 ,10 (26):11998

(22)杜微. Eliciting an immune hot tumor niche with biomimetic drug-based multi-functional nanohybrids augments immune checkpoint blockade-based breast cancer therapy .NANOSCALE .2020 ,12 (5):3317

(23)陈晨. Efficiently restoring the tumoricidal immunity against resistant malignancies via an immune nanomodulator .Journal of Controlled Release .2020 ,324 :574

(24)高琼琼. In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida albicans Infection .ACS nano .2020 ,14 (4):3980

(25)Jiang Xinyi. Efficiently Restoring the Tumoricidal Immunity Resistant Malignancies via an Immune Nanomodulator .Journal of Controlled Release .2020

(26)Jiang Xinyi. Eliciting an Immune Hot Tumor Niche with Biomimetic Drug-based Multi-functional Nanohybrids Augments Immune Checkpoint Blockade-based Breast Cancer Therapy .Nanoscale .2020 :3317

(27)Jiang Xinyi. In situ mannosylated nanotrinity-mediated macrophages remodeling combats Candida albicans infection .ACS nano .2020

(28)Jiang Xinyi. Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells .Theranostics .2018

1. 靶向MRSA嵌合抗原受体、药物递送体、CAR-巨噬细胞及应用

2. 一种基于Tris的可电离脂质及其制备方法与应用

3. 一种碱基可电离脂质及其制备方法与应用

4. 基于1,4-二氧六环-2,5-二酮母核的可电离脂质及其制备方法与应用

5. 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用

6. 基于内源性二羧酸的可电离脂质及其制备方法与应用

7. 一种可注射水凝胶的制备方法及其在术后肿瘤治疗中的应用

8. 一种金属多酚纳米复合物及其制备方法和应用

9. 在体生成CAR-巨噬细胞的制备方法及肿瘤免疫治疗中的应用

10. 一种ICD诱导剂-IDO抑制剂及制备方法与应用

11. 一种超分子纳米药物及在制备抗肿瘤制剂中的应用

12. 一种乏氧响应脂质体及在制备抗肿瘤药物中的应用

13. 一种基因与化学小分子共递送系统及在肿瘤治疗中的应用

14. 聚乙二醇化的ICD诱导剂-IDO抑制剂纳米缀合物及制备方法与应用

1. （包干项目）核酸递释载体与成药性, 2024/08/23-2029/12/31

2. CAR-巨噬细胞在体编辑载体及内吞增效机制研究, 2023/12/28-2026/12/31

3. 纳米肿瘤疫苗关键科学问题及设计原理研究, 2023/01/01-2025/12/31

4. 基于“肿瘤芯片”的siRNA纳米制剂优化及其调控胆固醇代谢治疗脑胶质瘤机制研究, 2021/12/13-2024/09/30

5. 重大核酸创新药物靶向递送载体关键技术研究与开发, 2021/10/29-2024/12/31

6. 基于纳米载体-水凝胶杂合系统的小胶质/巨噬细胞CAR结构编辑及其治疗术后脑胶质瘤免疫机制研究, 2021/08/18-2025/12/31

7. 基于纳米载体-水凝胶杂合系统的小胶质/巨噬细胞CAR结构编辑及其治疗术后脑胶质瘤免疫机制研究, 2021/10/12-2025/12/31

8. 靶向肝癌的 RNAi 智能纳米递送系统设计与研发关键技术, 2019/06/01-2021/12/31

9. 用于乏氧实体瘤治疗的高效给药系统的研发, 2019/07/08-2021/12/31

10. 靶向肝癌的RNAi智能纳米递送系统设计与研发关键技术-1, 2019/11/21-2021/12/31

11. 基于干细胞源性外泌体的恶性实体肿瘤深部递药和克服化疗耐药新策略研究, 2019/07/08-2021/11/30

12. 基于“自体白蛋白修饰”策略构建仿生隐身型小分子自组装纳米药物, 2019/04/26-2022/06/30