Jia Rui, Professor, PhD Supervisor, National Young Talent, Outstanding Young Scholar of Shandong University.

He obtained his Ph.D. in Microbiology from Nankai University in June 2013;

In March 2014, he worked as a postdoctoral researcher in Juan Bonifacino's laboratory at the National Institutes of Health in the United States;

In December 2021, he joined the Department of Cell Biology, School of Basic Medical Sciences, Shandong University.

His main research areas focus on lysosome function and the regulatory mechanisms of cellular autophagy. He studies the molecular mechanisms of autophagy regulation in multiple aspects, including autophagy signaling pathways, autophagosome-lysosome fusion, lysosomal function regulation, and LC3 protein expression levels. Utilizing CRISPR-Cas9 screening technology, he searches for new autophagy regulatory factors and elucidates the regulatory network of cellular autophagy at the genome-wide level. He has designed and developed CRISPR-Cas9 KO libraries targeting specific cellular pathways to investigate their regulation of cellular autophagy. His research findings are of great significance for systematically understanding the molecular mechanisms of autophagy regulation and have actively explored therapeutic approaches for chronic degenerative neurological diseases. Relevant research results have been published in international renowned academic journals such as Molecular Cell, Autophagy, eLife, etc., as the first author or corresponding author.

List of Published Articles: https://www.ncbi.nlm.nih.gov/myncbi/1HKMcgeNOFeA4/bibliography/public/

Ongoing Projects: National Young Talent Project, National Natural Science Foundation of China General Program, Shandong Province Excellent Young Scientist Fund Project. Total funding amount is approximately 4 million yuan.

Contact Information: rui.jia@email.sdu.edu.cn

WeChat: LYSAUT

Research Group co-PI: Liu Ruikang, Researcher, Master's Supervisor. He obtained his Ph.D. in Microbiology from Nankai University in 2013. Subsequently, he conducted postdoctoral research in the laboratory of Dr. Bernard Moss, a member of the National Academy of Sciences, at the National Institutes of Health.

His research direction is the interaction between orthopoxviruses and the innate immune system. His research findings have been published in journals such as PNAS, PLOS Pathogens, Cell Reports, Journal of Virology, etc.

Ongoing Projects: National Natural Science Foundation of China Monkeypox Special Project, National Natural Science Foundation of China Young Scientist Project, Shandong Province Excellent Young Scientist Fund Project. Total funding amount is 1.5 million yuan.