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Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
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Affiliation of Author(s):药学院
Journal:《Journal of Medicinal Chemistry》
First Author:康东伟
Document Code:24B3E869578743DF97EB522824BCB24E
Volume:63
Issue:9
Page Number:4837
Translation or Not:no
Date of Publication:2020-05-14
Pre One:Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
Next One:In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
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