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Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
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Affiliation of Author(s):药学院
Journal:《Journal of Medicinal Chemistry》
First Author:康东伟
Document Code:F9ADF0C8EA084D45ADB7BC5E60FF8659
Volume:63
Issue:3
Page Number:1298
Translation or Not:no
Date of Publication:2020-02-13
Pre One:Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
Next One:Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
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