王培会，男，2019年入职山东大学高等医学研究院，聘为教授、博士生导师、泰山学者青年专家、齐鲁青年学者。

 

教育背景

香港大学      香港          博士          抗病毒免疫学                2011/09-2015/08         

中山大学      广州   硕士          生物学         2008/09-2011/06                   

中山大学      广州   学士   生物技术       -2004/09-2008/06              

 

工作经历

教授PI              山东大学    高等医学研究院                2019/04-

博士后             香港大学    李嘉诚医学院                    2016/01-2019/02

研究助理         香港大学    李嘉诚医学院                    2015/10-2015/12

 

博士后招聘

本实验室实施精英教育，提供国际接轨的科研平台、一流的学术环境和氛围、顶级的实验条件，以及高水平的研究课题。欢迎生命科学、医学、农学等生命科学相关方向博士加盟团队，进行博士后研究(常年有效、2-3名、择优录取)。 

研究生招生

实验室现有教授1名、博士后2名、博士3名、硕士3名。欢迎有志青年报考硕士和博士研究生，报考前请提前与导师联系，确认当年是否有招生名额。 

研究方向

1. 病毒逃逸宿主免疫建立感染的机制。以病毒与宿主相互作用为切入点，揭示病毒与宿主相互作用的关键节点分子，为开发抗病毒药物提供新的思路和靶点。代表性成果：发现新冠病毒的感染机制以及与抗病毒免疫的相互作用 (Cell Chem Biol 2022; Signal Transduct Target Ther 2022, 2021, 2020a, 2020b; Nat Biotechnol 2022; Nat Metab 2021; Nat Chem Biol 2022; Sci Adv 2021)。

 

           

    

                    

                     

2.  抗病毒免疫的调控机制。通过大规模、高通量的筛选技术，鉴定在抗病毒免疫中，发挥调控作用的蛋白，并揭示这些蛋白在宿主识别病毒、免疫激活中挥发的作用。代表性成果：发现了病毒DNA在细胞质内的主要识别通路AIM2和cGAS-STING的新调控分子及其作用机制 (EMBO Rep 2018 封面文章; Nucleic Acids Res 2018)。 

                         

 

  学术影响

  在Nature Biotechnology、Signal Transduction and Targeted Therapy、Nature Metabolism、Nature Chemical Biology、Nucleic Acids Research、Cell Chemical Biology、Science Advances、Cell Research、EMBO Reports等期刊累计发表学术论文50余篇，被Nature、Science、Cell、Lancet及其子刊等引用4500余次，H指数39。

  媒体报道

研究成果被山东电视台、人民日报海外版、央广网、凤凰网、香港文汇网、光明日报、搜狐网、网易、新浪微博、腾讯网、中国教育在线、中华网、齐鲁网、齐鲁壹点等数十家媒体采访和报道。

1.   山东新闻联播，视频采访-山东大学科研团队取得新进展 揭示新冠病毒如何实现免疫逃逸

     (http://sd.iqilu.com/share/video/4870355)

2.   山东电视台《民生实验室》，视频采访-新冠病毒是如何进入我们身体的？

     (http://sd.iqilu.com/share/video/4771911)

3. 济南广播电视台天下泉城新闻，视频采访-山东大学：传承百年齐鲁医学 汇聚磅礴发展力量 

     (https://jntxqc.tianxiaquanchengapp.com/webshare/yw/202447.shtml?share=true)

4.   凤凰网-山大团队发现冠状病毒感染诱导其受体ACE2上调 

     (https://ishare.ifeng.com/c/s/7uSW3uDoUzL)

5.  人民日报海外版-研究人员：新冠病毒或通过诱导其受体ACE2的表达增强感染传播力

     (http://m.haiwainet.cn/middle/3541434/2020/0229/content_31730390_1.html)

6.  香港文汇网-山東大學聯合港大發現冠狀病毒感染誘導其受體ACE2上調 

     (http://news.wenweipo.com/2020/02/29/IN2002290025.htm)

7. 光明日报-山东大学高等医学研究院无偿提供新型冠状病毒编码基因表达载体

    (https://overseas.weibo.com/detail/4467560139093209 ;

    https://new.qq.com/omn/20200202/20200202A0HJK400.html)

8.  央广网-研究人员：新冠病毒或通过诱导其受体ACE2的表达增强感染传播力 

    (http://www.cnr.cn/sd/gd/20200229/t20200229_524996973.shtml)

9.  大众日报-山东大学团队发现冠状病毒感染诱导其受体ACE2上调

     ( http://dzrb.dzng.com/articleContent/1176_730304.html)

10. 光明日报-科技战疫彰显高校担当 

    (https://news.gmw.cn/2020-03/25/content_33681654.htm)

 

学术服务

Front Immunol (IF 8.786) 副主编 (Associate Editor)

Front Pharmacol (IF 5.988) 副主编 (Associate Editor)

Front Bioeng Biotechnol (IF 6.064) 副主编 (Associate Editor)

Comp Immunol Microb (IF 2.729) 副主编 (Associate Editor)

审稿服务

Signal Transduction and Targeted Therapy (IF 38.104)

ACS Nano (IF 17.1)

Biomaterials (IF 13.8)

EMBO Molecular Medicine  (IF 11.4)

Cell systems (IF 10.9)

Cell Reports (IF 9.9)

EMBO Reports (IF 8.6) 等期刊

基金评审

欧洲研究理事会European Research Council (ERC)国际评审人

奥地利科学基金会(Austrian Science Fund, FWF)国际评审人

国家重点研发计划评审人

Google Scholar 个人主页：

https://scholar.google.com/citations?user=NdwuOG0AAAAJ&hl=en 

Web of Science个人主页：

https://www.webofscience.com/wos/author/record/696976 

代表性论著（*通讯作者，#共同第一作者，2023年3月更新）  

  

030.   Jian Deng^#, Sheng-Nan Zheng^#, Yang Xiao^#, Mei-Ling Nan, Jing Zhang, Lulu Han, Yi Zheng, Yanying Yu, Qiang Ding, Chengjiang Gao, Pei-Hui Wang*. SARS-CoV-2 NSP8 suppresses type I and III IFN responses by modulating the RIG-I/MDA5, TRIF, and STING signaling pathways. J Med Virol. 2023 Mar 17. DOI: 10.1002/jmv.28680. (IF 20.693) 

029.   Jian Deng^#, Yi Zheng^#, Sheng-Nan Zheng^#, Mei-Ling Nan^#, Lulu Han, Jing Zhang, Yunyun Jin, Ji-An Pan, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 NSP7 inhibits type I and III IFN production by targeting the RIG-I/MDA5, TRIF, and STING signaling pathways. J Med Virol. 2023 Feb 8. doi: 10.1002/jmv.28561. (IF 20.693)

028.   Lulu Han^#, Yi Zheng^#, Jian Deng^#, Mei-Ling Nan, Yang Xiao, Meng-Wei Zhuang, Jing Zhang, Wei Wang, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2  ORF10 antagonizes STING-dependent interferon activation and autophagy. J Med Virol. 2022 Nov;94(11):5174-5188.(IF 20.693) 

027.   Yi Zheng^#, Jian Deng^#, Lulu Han^#, Meng-Wei Zhuang, Yanwen Xu, Jing Zhang, Mei-Ling Nan, Yang Xiao, Peng Zhan, Xinyong Liu, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 NSP5 and N Protein Counteract the RIG-I Signaling Pathway by Suppressing the Formation of Stress Granules. Signal Transduct Target Ther. 2022 Jan 24;7(1):22.  (IF 38.104；ESI高被引论文)

026.   Yuehui Zhang^#, Limin Shang^#, Jing Zhang^#, Yuchen Liu^#, Chaozhi Jin^#, Yanan Zhao^#, Xiaobo Lei^#, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang*, Fuchu He*, Pei-Hui Wang*, Jian Wang*. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Cell Chem Biol. 2022 Jan 20;29(1):5-18.e6. (Featured as a cover story, IF 9.039)

025.   Zhuanchang Wu^#,*, Zhaoying Zhang^#, Xin Wang^#, Jing Zhang^#, Caiyue Ren, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang*, Chunhong Ma*. Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther. 2021 Jun 11;6(1):231. (IF 38.104)

024.   Yi Zheng^#, Meng-Wei Zhuang^#, Lulu Han, Jing Zhang, Mei-Ling Nan, Peng Zhan, Dongwei Kang, Xinyong Liu, Chengjiang Gao*, Pei-Hui Wang*. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling. Signal Transduct Target Ther. 2020 Dec 28;5(1):299. (IF 38.104；ESI高被引论文)

023.   Jing Zhang^#, Ruth Cruz-Cosme^#, Meng-Wei Zhuang, Dongxiao Liu, Yuan Liu, Shaolei Teng, Pei-Hui Wang*, Qiyi Tang*. A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins. Signal Transduct Target Ther. 2020 Nov 17;5(1):269. (IF 38.104)

022.    Lulu Han^#, Meng-Wei Zhuang^#, Jian Deng^#, Yi Zheng, Jing Zhang, Mei-Ling Nan, Xue-Jing Zhang, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways. J Med Virol. 2021 Apr 29;10.1002/jmv.27050. (IF 20.693；ESI高被引论文)

021.    Meng-Wei Zhuang^#, Yun Cheng^#, Jing Zhang^#, Xue-Mei Jiang, Li Wang, Jian Deng, Pei-Hui Wang*. Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection. J Med Virol. 2020 Nov;92(11):2693-2701. (IF 20.693)

020.   Pei-Hui Wang, Sin-Yee Fung, Wei-Wei Gao, Jian-Jun Deng, Yun Cheng, Vidyanath Chaudhary, Kit-San Yuen, Ting-Hin Ho, Ching-Ping Chan, Yan Zhang, Kin-Hang Kok, Wanling Yang, Chi-Ping Chan, Dong-Yan Jin*. Identification and characterization of a novel transcript isoform of STING that dominantly inhibits innate immune response. Nucleic Acids Res. 2018 May 4;46(8):4054-4071. (IF 19.16) 

019.   Pei-Hui Wang, Zi-Wei Ye, Jian-Jun Deng, Kam-Leung Siu, Wei-Wei Gao, Vidyanath Chaudhary, Yun Cheng, Sin-Yee Fung, Kit-San Yuen, Ting-Hin Ho, Ching-Ping Chan, Yan Zhang, Kin-Hang Kok, Wanling Yang, Chi-Ping Chan, Dong-Yan Jin*. Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. EMBO Rep. 2018 Otc;19(10). (Featured as a cover story, IF 9.071)

018.    Meng-Wei Zhuang^#, Yun Cheng^#, Jing Zhang^#, Xue-Mei Jiang, Li Wang, Jian Deng, Pei-Hui Wang*. Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection. J Med Virol. 2020 Nov;92(11):2693-2701. (IF 20.693)

017.    Bin Wang^#, Li Wang^#, Xianggen Kong, Jin Geng, Di Xiao, Chunhong Ma, Xue-Mei Jiang, Pei-Hui Wang*. Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients. J Med Virol. 2020 Sep;92(9):1684-1689. (IF 20.693；ESI高被引论文)

016.    Pei-Hui Wang^#, Tianzhi Huang^#, Xiaobo Zhang*, Jian-Guo He*. Antiviral defense in shrimp: from innate immunity to antiviral infection. Antiviral Res 2014 Aug;108:129-41. (IF 10.103)

015.    Pei-Hui Wang*, Li-Shi Yang, Zhi-Hua Gu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Nucleic acid-induced antiviral immunity in shrimp. Antiviral Res. 2013 Sep;99(3):270-80. (IF 10.103)

 

其他主要论著

014.    Fei Li^#, Jingyao Li^#, Pei-Hui Wang^#, Nanyan Yang, Junyu Huang, Jinxin Ou, Ting Xu, Xin Zhao, Taoshu Liu, Xueying Huang, Qinghuan Wang, Miao Li, Le Yang, Yunchen Lin, Ying Cai, Haisheng Chen, Qing Zhang*. SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. Biochim Biophys Acta Mol Basis Dis. 2021 Aug 27;1867(12):166260. (IF 6.633)

013.    Yun Zhu, Jian Deng, Mei-Ling Nan, Jing Zhang, Akinkunmi Okekunle, Jiang-Yuan, Xiao-Qiang Yu, Pei-Hui Wang*. The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation. Adv Exp Med Biol. 2019;1209:79-108. (IF 2.622)

012.    Pei-Hui Wang* and Jian-Guo He*. Nucleic acid sensing in invertebrates. Int Rev Cel Mol Bio. 2019;345:287-360. (IF 6.42)

011.Jian Deng and Pei-Hui Wang*. Inflammasome Activation and Th17 responses. Mol Immunol 2019 Mar;107:142-164. (IF 4.174)

010.    Pei-Hui Wang*, Shao-Ping Weng, Jian-Guo He*. Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective. Dev Comp Immunol. 2015 Feb;48(2):291-6. (IF 3.605)

009.    Pei-Hui Wang*, Ding-Hui Wan, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Characterization of four novel caspases from Litopenaeus vannamei (Lvcaspase2-5) and their role in WSSV infection through dsRNA-mediated gene silencing. PLoS One. 2013 Dec 23;8(12):e80418. (IF 3.752)

008.    Pei-Hui Wang*, Ding-Hui Wan, Zhi-Hua Gu, Wei Qiu, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Analysis of expression, cellular localization, and function of three inhibitors of apoptosis (IAPs) from Litopenaeus vannamei during WSSV infection and in regulation of antimicrobial peptide genes (AMPs). PLoS One. 2013 Aug 14;8(8):e72592. (IF 3.752)

007.    Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei Toll-interacting protein (LvTollip) is a potential negative regulator of the shrimp Toll pathway involved in the regulation of the shrimp antimicrobial peptide gene penaeidin-4 (PEN4). Dev Comp Immunol. 2013 Jul-Aug;40(3-4):266-77. (IF 3.605)

006.    Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei Sterile-Alpha and Armadillo Motif Containing Protein (LvSARM) Is Involved in Regulation of Penaeidins and antilipopolysaccharide factors. PLoS One. 2013;8(2):e52088. (IF 3.752)

005.    Pei-Hui Wang*, Jian-Ping Liang, Zhi-Hua Gu, Ding-Hui Wan, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Molecular cloning, characterization and expression analysis of two novel Tolls (LvToll2 and LvToll3) and three putative Spätzle-like Toll ligands (LvSpz1-3) from Litopenaeus vannamei. Dev Comp Immunol. 2012 Feb;36(2):359-71. (IF 3.605)

004.    Pei-Hui Wang, Ding-Hui Wan, Li-Ran Pang, Zhi-Hua Gu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Molecular cloning, characterization and expression analysis of the tumor necrosis factor (TNF) superfamily gene, TNF receptor superfamily gene and lipopolysaccharide-induced TNF-α factor (LITAF) gene from Litopenaeus vannamei. Dev Comp Immunol. 2012 Jan;36(1):39-50. (IF 3.605)

003.    Pei-Hui Wang, Zhi-Hua Gu, Ding-Hui Wan, Ming-Yan Zhang, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. The shrimp NF-κB pathway is activated by white spot syndrome virus (WSSV) 449 to facilitate the expression of WSSV069 (ie1), WSSV303 and WSSV371. PLoS One. 2011;6(9):e24773. (IF 3.752)

002.    Pei-Hui Wang, Ding-Hui Wan, Zhi-Hua Gu, Xie-Xiong Deng, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei tumor necrosis factor receptor-associated factor 6 (TRAF6) responds to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection and activates antimicrobial peptide genes. Dev Comp Immunol. 2011 Jan;35(1):105-14. (IF 3.605)

001.    Pei-Hui Wang^#, Zhi-Hua Gu^#, Xian-De Huang, Bo-Du Liu, Xie-xiong Deng, Hua-Shui Ai, Jing Wang, Zhi-Xin Yin, Shao-Ping Weng, Xiao-Qiang Yu*, Jian-Guo He*. An immune deficiency homolog from the white shrimp, Litopenaeus vannamei, activates antimicrobial peptide genes. Mol Immunol. 2009 May;46(8-9):1897-904. (IF 4.174)

 

合作论著

035.    Peng Zhang^#, Yu Liu^#, Chunfeng Li^#, Lindsay D Stine, Pei-Hui Wang, Matthew W Turnbull 1, Haodi Wu*, Qing Liu*. Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes. Front Cell Dev Biol. 2023 Feb 22;11:1110271. doi: 10.3389/fcell.2023.1110271. eCollection 2023.

034.    Jiaxin Yang^#, Yan Li^#, Shijin Wang, Huili Li, Lili Zhang, Haichen Zhang, Pei-Hui Wang, Xiangyu Zheng, Xiao-Fang Yu, Wei Wei*. The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates. Signal Transduct Target Ther. 2023 Mar 9;8(1):109. doi: 10.1038/s41392-023-01386-8.

033.    Zhuanchang Wu^#, Xiaobo Lei^#, Xin Wang^#, Zhaoying Zhang, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang, Jianwei Wang*, Chunhong Ma*. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19. doi: 10.1038/s41392-022-01244-z.

032.    Yadi Zhou^#, Yuan Liu^#, Shagun Gupta^#, Mauricio I Paramo^#, Yuan Hou^#, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T Lis, Cédric Feschotte, Serpil C Erzurum, Feixiong Cheng*, Haiyuan Yu*. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nat Biotechnol. 2022 Oct 10. doi: 10.1038/s41587-022-01474-0.

031.    Hui Wang^#, Danrong Shi^#, Penglei Jiang, Zebin Yu, Yingli Han, Zhaoru Zhang, Peihui Wang, He Huang, Hangping Yao*, Pengxu Qian*. SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication. Signal Transduct Target Ther. 2022 Oct 8;7(1):356. doi: 10.1038/s41392-022-01210-9.

030.    Xiao Liang^#, Jun Xiao^#, Xuzichao Li 1, Yujie Liu, Yao Lu, Yanan Wen, Zexing Li, Xing Che, Yongjian Ma, Xingyan Zhang, Yi Zhang, Deng Jian, Peihui Wang, Chenghao Xuan, Guimei Yu*, Long Li*, Heng Zhang*. A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Nat Chem Biol. 2022 Aug 18. doi: 10.1038/s41589-022-01128-x.

029.    Yao Ma^#, Mei Luo^#, Yusheng Deng^#, Xiaoman Yang, Xionglue Wang, Guozhong Chen, Zixin Qin, Yun Deng, Meiling Nan, Yang Chen, Peihui Wang, Hong Wei, Lijuan Han*, Xiaodong Fang*, Zhi Liu*. Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut. Front Cell Infect Microbiol. 2022 Jul 28;12:896504.

028.    Wenying Gao^#, Liuli Wang^#, Xiaohui Ju, Simin Zhao, Zhaolong Li, Manman Su, Jiancheng Xu, Peihui Wang, Qiang Ding, Guoyue Lv*, Wenyan Zhang*. The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b. mBio. 2022 Jun 28;13(3):e0130022.

027.    Limin Shang*, Yuehui Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Jing Zhang, Pei-Hui Wang, Jian Wang*. An antibody-based proximity labeling protocol to identify biotinylated interactors of SARS-CoV-2. STAR Protoc. 2022 May 2;3(2):101406.

026.    Xuan Tao, Lu Zhang, Liubing Du, Kai Lu, Zhennan Zhao, Yanxuan Xie, Xiaobo Li, Shuxiang Huang, Pei-Hui Wang, Ji-An Pan, Wei Xia, Jun Dai, Zong-Wan Mao.  Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol. J Inorg Biochem. 2022 Mar 1;231:111777.

025.    Xiaolin Zhang, Ziwei Yang, Ting Pan, Xubing Long, Qinqin Sun, Pei-Hui Wang, Xiaojuan Li, Ersheng Kuang. SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection. Autophagy. 2022 Mar 3;1-17.

024.    Yang Yang^#, Yongjian Wu^#, Xiaojun Meng, Zhiying Wang, Muhammad Younis, Ye Liu, Peihui Wang, Xi Huang*. SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK. Cell Death Differ. 2022 Jan 12. doi: 10.1038/s41418-022-00928-x

023.    Luming Wan^#, Qi Gao^#, Yongqiang Deng^#, Yuehua Ke^#, Enhao Ma^#, Huan Yang^#, Haotian Lin^#, Huilong Li, Yilong Yang, Jing Gong, Jingfei Li, Yixin Xu, Jing Liu, Jianmin Li, Jialong Liu, Xuemiao Zhang, Linfei Huang, Jiangyue Feng, Yanhong Zhang, Hanqing Huang, Huapeng Wang, Changjun Wang, Qi Chen, Xingyao Huang, Qing Ye, Dongyu Li, Qiulin Yan, Muyi Liu, Meng Wei, Yunhai Mo, Dongrui Li, Ke Tang, Changqing Lin, Fei Zheng, Lei Xu, Gong Cheng, Peihui Wang, Xiaopan Yang*, Feixang Wu*, Zhiwei Sun*, Chengfeng Qin*, Congwen Wei*, Hui Zhong*. GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia. Nat Metab. 2022 Jan 6. doi: 10.1038/s42255-021-00508-2.

022.    Yongjian Wu, Manni Wang, Huan Yin, Siqi Ming, Xingyu Li, Guanmin Jiang, Ye Liu, Peihui Wang, Guangde Zhou, Lei Liu, Sitang Gong, Haibo Zhou, Hong Shan, Xi Huang*. TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection. Sci Adv. 2021 Dec 10;7(50):eabi6802.

021.    Fanghang Zhou^#, Qianya Wan^#, Sheng Chen^#, Ying Chen, Pui-Hui Wang, Xi Yao*, Ming-Liang He*. Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization. Signal Transduct Target Ther. 2021 Oct 26;6(1):371.

020.    Xuan Tao, Lu Zhang, Liubing Du, Ruyan Liao, Huiling Cai, Kai Lu, Zhennan Zhao, Yanxuan Xie, Pei-Hui Wang, Ji-An Pan, Yuebin Zhang*, Guohui Li*, Jun Dai*, Zong-Wan Mao* and Wei Xia*. Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate. Chem Sci. 2021 Sep 24;12(42):14098-14102.

019.    Wei Hu^#, Yong Zhang^#, Panyu Fei^#, Tongtong Zhang^#, Danmei Yao^#, Yufei Gao, Jia Liu, Hui Chen, Qiao Lu, Tenny Mudianto, Xinrui Zhang, Chuxuan Xiao, Yang Ye, Qiming Sun, Jing Zhang, Qi Xie, Pei-Hui Wang, Jun Wang*, Zhenhai Li*, Jizhong Lou*, Wei Chen*. Mechanical activation of spike fosters SARS-CoV-2 viral infection. Cell Res. 2021 Aug 31;1-14.

018.    Ye Zhou^#, Mu Wang^#, Yunhui Li^#, Peihui Wang, Ping Zhao, Zixuan Yang, Suyuan Wang, Liyuan Zhang, Zhenyang Li, Kaiwei Jia, Cuiping Zhong, Nan Li, Yizhi Yu, Jin Hou. SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium. Immunol Lett. 2021 Sep;237:33-41.

017.    Aixin Li^# , Kaitao Zhao^#, Bei Zhang, Rong Hua, Yujie Fang, Wuhui Jiang, Jing Zhang, Lixia Hui, Yingcheng Zheng, Yan Li, Chengliang Zhu, Pei-Hui Wang, Ke Peng, Yuchen Xia*. SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist. J Virol. 2021 Aug 10;95(17):e0074721.

016.    Feima Wu, Yan Chen, Kai You, Shenglin Tan, Yingying Xu, Pei-Hui Wang, Shiming Liu*, Yin-Xiong Li*. Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid protein. Stem Cell Res. 2021 May;53:102197.

015.    Xiaoyuan Lin^#, Beibei Fu^#, Songna Yin^#, Zhifeng Li, Huawen Liu, Haiwei Zhang, Na Xing, Yu Wang, Weiwei Xue, Yan Xiong, Shanfu Zhang, Qingting Zhao, Shiyao Xu, Jing Zhang, Peihui Wang, Weiqi Nian*, Xingsheng Wang*, Haibo Wu*. ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293.

014.    Huan Ma, Weihong Zeng, Xiangzhi Meng, Xiaoxue Huang, Yunru Yang, Dan Zhao, Peigen Zhou, Xiaofang Wang, Changcheng Zhao, Yong Sun, Peihui Wang, Huichao Ou, Xiaowen Hu, Yan Xiang*, Tengchuan Jin*. Potent Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain. J Virol. 2021 Mar 3;95(10):e02438-20.

013.    Chen Xie^#, Yanlian Chen^#, Dongling Luo, Zhen Zhuang, Heping Jin, Haoxian Zhou, Xiaocui Li, Haijun Lin, Xiaohui Zheng, Jing Zhang, Peihui Wang, Jincun Zhao, Yong Zhao*, Hui Huang*. Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7. Signal Transduct Target Ther. 2021 Feb 22;6(1):84.

012.    Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Yuhai Bi, Peihui Wang, Hong Zhang*. ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Dev Cell. 2021 Feb 22;56(4):427-442.e5.

011.    Yaoxing Wu, Ling Ma, Zhen Zhuang, Sihui Cai, Zhiyao Zhao, Lingli Zhou, Jing Zhang, Pei-Hui Wang, Jincun Zhao*, Jun Cui*. Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling. Signal Transduct Target Ther. 2020 Oct 6;5(1):221.

010.    Hui Chen, Yang Cui, Xuling Han, Wei Hu, Min Sun, Yong Zhang, Pei-Hui Wang, Guangtao Song, Wei Chen*, Jizhong Lou*. Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA. Cell Res. 2020 Dec;30(12):1143-1145.

009.    He-Wei Jiang^#, Hai-Nan Zhang^#, Qing-Feng Meng^#, Jia Xie^#, Yang Li, Hong Chen, Yun-Xiao Zheng, Xue-Ning Wang, Huan Qi, Jing Zhang, Pei-Hui Wang, Ze-Guang Han, Sheng-Ce Tao*. SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. Cell Mol Immunol. 2020 Sep;17(9):998-1000.

008.    Vidyanath Chaudhary, Kit-San Yuen, Jasper Fuk-Woo Chan, Ching-Ping Chan, Pei-Hui Wang, Jian-Piao Cai, Shuo Zhang, Mifang Liang, Kin-Hang Kok, Chi-Ping Chan, Kwok-Yung Yuen, Dong-Yan Jin*. Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein. J Virol. 2017 Jun 26;91(14):e00163-17.

007.    Chun-Kit Yuen, Ching-Ping Chan, Sin-Yee Fung, Pei-Hui Wang, Wan-Man Wong, Hei-Man Vincent Tang, Kit-San Yuen, Chi-Ping Chan, Dong-Yan Jin*, Kin-Hang Kok*. Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation. J Virol. 2016 Mar 28;90(8):3902-3912.

006.    Vidyanath Chaudhary^#, Shuo Zhang^#, Kit-San Yuen, Chuan Li, Pak-Yin Lui, Sin-Yee Fung, Pei-Hui Wang, Chi-Ping Chan, Dexin Li, Kin-Hang Kok, Mifang Liang*, Dong-Yan Jin*. Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation. J Gen Virol. 2015 Nov;96(11):3204-3211.

005.    Wei Qiu, Shuang Zhang, Yong-Gui Chen, Pei-Hui Wang, Xiao-Peng Xu, Chao-zheng Li, Yi-Hong Chen, Wen-Zhou Fan, Hui Yan, Shao-Ping Weng, Siuming Francis Chan, Jian-Guo He*. Litopenaeus vannamei NF-κB is required for WSSV replication. Dev Comp Immunol. 2014 Jul;45(1):156-62.

004.    Shuang Zhang, Chao-Zheng Li, Hui Yan, Wei Qiu, Yong-Gui Chen, Pei-Hui Wang, Shao-Ping Weng, Jian-Guo He*. Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei. PLoS One. 2012;7(10):e47038.

003.    Xian-De Huang, Li Zhao, Hai-Qing Zhang, Xiao-Peng Xu, Xiao-Ting Jia, Yi-Hong Chen, Pei-Hui Wang, Shao-Ping Weng, Xiao-Qiang Yu, Zhi-Xin Yin, Jian-Guo He. Shrimp NF-κB binds to the immediate-early gene ie1 promoter of white spot syndrome virus and upregulates its activity. Virology. 2010 Oct 25;406(2):176-80.

002.    Xian-De Huang, Zhi-Xin Yin*, Xiao-Ting Jia, Jian-ping Liang, Hua-Shui Ai, Li-Shi Yang, Xi Liu, Pei-Hui Wang, Se-dong Li, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Identification and functional study of a shrimp Dorsal homologue. Dev Comp Immunol. 2010 Feb;34(2):107-13.

001.    Xian-De Huang^#, Zhi-Xin Yin^#, Ji-Xiang Liao, Pei-Hui Wang, Li-Shi Yang, Hua-Shui Ai, Zhi-Hua Gu, Xiao-Ting Jia, Shao-Ping Weng, Xiao-Qiang Yu*, Jian-Guo He*. Identification and functional study of a shrimp Relish homologue. Fish Shellfish Immunol. 2009 Aug;27(2):230-8.

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