Biography

Dr. Hao Wu is a full professor at Department of Nutrition and Food Hygiene, School of Public Heatlh, Cheeloo College of Medicine, Shandong University, China. He is the P.I. of Spatial Nutrition Research Team at Shandong University. He acquired M.D. and Ph.D. at Jilin University, and received post-doctoral training at University of Louisville and Vanderbilt University Medical Center, USA.
    He proposed a novel concept in nutrition research named “Spatial Nutrition” which aims to define the interaction between disordered spatial distribution of nutrients in the body and nutritional disease (especially diabetes and complications), and investigate the effect and mechanism of targeted delivery of nutrients and food bioactives towards specific organs/cells/organelles. Spatial nutrition may conquer the unsatisfactory absorption and utilization of nutrients under disease/non-disease conditions, and may yield better outcomes.
    He has published 25 articles as the first or corresponding author in top journals such as Diabetologia, Free Radical Biology & Medicine, Journal of Agricultural and Food Chemistry and Nutrients. He is an editorial board member of international journals such as Nutrients, Antioxidants and Frontiers in Endocrinology. He serves as a reviewer for Food & Function, Food and Chemical Toxicology, Journal of Functional Foods, Oxidative Medicine and Cellular Longevity, etc.
    He is a standing committee member in Basic Nutrition Branch, Chinese Nutrition Society. His research is funded by National Natural Science Foundation of China, Shandong University, Jilin University and Jinan Central Hospital.



Working-Papers

1. Spatial nutrition: to investigate the interaction between abnormal distribution of nutrients in the body and diseases, and to optimize the distribution of nutrients and food bioactives in order to gain a better health outcome.

2. Molecular nutrition

3. Functional foods

4. Diabetes and complications

Publication
Papers

(1) 陆中婷. Theabrownin from Fu Brick tea ameliorates high-fat induced insulin resistance, hepatic steatosis, and inflammation in mice by altering the composition and metabolites of gut microbiota? .FOOD & FUNCTION .2024 (15):4421

(2)  Local application of krill oil accelerates the healing of artificially created wounds in diabetic mice .NUTRIENTS .2022 (14)

(3) 田奥. Krill oil attenuates diabetes-associated cognitive dysfunction by inhibiting microglial polarization-induced neuron injury .JOURNAL OF FUNCTIONAL FOODS .2024 (Volume 114)

(4)  Cardamonin targets KEAP1/NRF2 signaling in protection against atherosclerosis. .FOOD & FUNCTION .2022 (Issue 10, 2023)

(5) 田奥. Eicosapentaenoic acid activates the P62/KEAP1/NRF2 pathway for the prevention of diabetes-associated cognitive dysfunction .FOOD & FUNCTION .2024 (Advance Article)

(6) Hao, Yanyun. Site-specific nanoswitch circumventing immune resistance via activating TLR and inhibiting PD-L1/PD-1 axis .Journal of Controlled Release .2023 ,361 :64-76

(7) 梁啟剑. Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice .Food Science and Human Wellness .2023 (13):856

(8) 韩潇. 卵磷脂型二十碳五烯酸对细菌脂多糖所致急性肾损伤的影响 .中国海洋药物 .2023 ,42 (6):13

(9) 伍梓健. Eicosapentaenoic acid-enriched phospholipids alleviate skeletal muscle atrophy in Lewis Lung Carcinoma mouse model .Molecular nutrition & food research .2023 ,67 (13)

(10)  Local application of krill oil accelerates the healing of artificially created wounds in diabetic mice .NUTRIENTS .2022 (14)

(11) 吴昊. C66 ameliorates diabetic nephropathy by both inhibiting miR-21 and up-regulating Nrf2 function via increase in miR-200a .diabetologia .2016 (7)

(12) 孙雪纯. Krill oil turns off TGF-beta 1 profibrotic signaling in the prevention of diabetic nephropathy .Journal of Agricultural and Food Chemistry .2022 ,70 (32):9865

(13) 郭欣. The role of palmitoleic acid in regulating hepatic gluconeogenesis through SIRT3 in obese mice .NUTRIENTS .2022 ,14 (7):1482

(14) 杜磊. Krill oil prevents lipopolysaccharide-evoked acute liver injury in mice through inhibition of oxidative stress and inflammation .FOOD & FUNCTION .2022 ,13 (7):3853

(15) 孙雪纯. Krill oil inhibits NLRP3 inflammasome activation in the prevention of the pathological injuries of diabetic cardiomyopathy .NUTRIENTS .2022 ,14 (2):368

(16) 杜磊. DHA-enriched phospholipids and EPA-enriched phospholipids alleviate lipopolysaccharide-induced intestinal barrier injury in mice via a sirtuin 1-dependent mechanism .Journal of Agricultural and Food Chemistry .2022 ,70 (9):2911

(17)  DHA-enriched phospholipids and EPA-enriched phospholipids alleviate lipopolysaccharide-induced intestinal barrier injury in mice via a sirtuin 1 dependent mechanism. .Journal of Agricultural and Food Chemistry .2022

(18)  Krill oil inhibits NLRP3 inflammasome activation in prevention of pathological injuries of diabetic cardiomyopathy .Nutrients .2022

(19) 郝仪铭. 南极磷虾油对小鼠肠黏膜屏障的保护作用及机制 .食品科学技术学报 .2021 ,39 (4):64

(20)  Protective role of NRF2 in macrovascular complications of diabetes .Journal of Cellular and Molecular Medicine .2020 ,24 (16)

(21)  MicroRNA-200a improves diabetic endothelial dysfunction by targeting KEAP1/NRF2 .Journal of Endocrinology .2020 ,245 (1):129

(22)  Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1 .Journal of Cellular and Molecular Medicine .2019 ,23 (5):3538

(23)  P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy .Biochimica et Biophysica Acta - Molecular Cell Research .2019

(24)  Dimethyl fumarate accelerates wound healing under diabetic condition .Journal of Molecular Endocrinology .2018

(25)  MicroRNA-34a Targets Sirtuin 1 and Leads to Diabetes-induced Testicular Apoptotic Cell Death .Journal of Molecular Medicine .2018

(26)  Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2 .Free Radical Biology & Medicine .2018

(27)  MDM2 controls NRF2 antioxidant activity in prevention of diabetic kidney disease .Biochimica et Biophysica Acta - Molecular Cell Research .2018

(28)  SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53 .Journal of Endocrinology .2018

(29)  SP600125 Suppresses Keap1 Expression and Results in NRF2-mediated Prevention of Diabetic Nephropathy .Journal of Molecular Endocrinology .2018

(30)  Targeting Oxidative Stress in Diabetic Complications: New Insights .Journal of Diabetes Research .2018

(31)  Epigallocatechin Gallate Upregulates NRF2 to Prevent Diabetic Nephropathy via Disabling KEAP1 .Free Radical Biology & Medicine .2017

(32)  Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC .Journal of Endocrinology .2017

(33)  NRF2 plays a critical role in both self and EGCG protection against diabetic testicular damage .Oxidative Medicine and Cellular Longevity .2017

(34)  Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 .Oxidative Medicine and Cellular Longevity .2017

(35)  C66 ameliorates diabetic nephropathy by both inhibiting miR-21 and up-regulating Nrf2 function via increase in miR-200a .Diabetologia .2016

(36)  Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2 .Free Radical Biology & Medicine .2015

(37)  Sirtuin 1: a target for kidney diseases .Molecular Medicine .2015

(38)  Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice .Toxicology Letters .2014

(39)  The Role of MicroRNAs in Diabetic Nephropathy .Experimental Diabetes Research .2014

Research Group
Name of Research Group:
Spatial Nutrition Research Team
Description of Research Group:
Members:
Student Information
  • 苏政  2023/09/23 Hits:[] Times
  • 逄雪萍  2023/09/23 Hits:[] Times
  • 管佩玲  2023/09/23 Hits:[] Times
  • 陈廷伟  2023/09/23 Hits:[] Times
  • 邓旭  2023/09/23 Hits:[] Times
  • 周子慧  2023/09/23 Hits:[] Times
  • 李小焕  2023/09/23 Hits:[] Times
  • 孙雪纯  2023/09/23 Hits:[] Times
  • 殷嘉麟  2023/09/23 Hits:[] Times
  • 宋冬燕  2023/09/23 Hits:[] Times
  • 范鹏飞  2023/09/23 Hits:[] Times
  • 李杰  2023/09/23 Hits:[] Times
  • 郝文昊  2023/09/23 Hits:[] Times
  • 杨玉  2023/09/23 Hits:[] Times
  • 梁啟剑  2023/09/23 Hits:[] Times
  • Ao Tian  2022/12/13 Hits:[] Times
  • Huali Meng  2022/12/13 Hits:[] Times
  • Xuechun Sun  2022/12/13 Hits:[] Times
  • Jie Li  2022/12/13 Hits:[] Times
  • Wenhao Hao  2022/12/13 Hits:[] Times
  • Pengfei Fan  2022/12/13 Hits:[] Times
  • Dongyan Song  2022/12/13 Hits:[] Times
  • Jialin Yin  2022/12/13 Hits:[] Times
  • Xiaohuan Li  2022/12/13 Hits:[] Times
  • Zihui Zhou  2022/12/13 Hits:[] Times
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