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个人信息Personal Information
研究员 硕士生导师
性别：男
学历：博士研究生毕业
学位：医学博士学位
在职信息：在职
所在单位：药学院
入职时间：2020-10-22
学科：药物化学
联系方式：18663770120
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- [21] 康东伟. Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs. ACTA PHARMACEUTICA SINICA B, 10, 878, 2020.
- [22] 康东伟. 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. 《Journal of Medicinal Chemistry》, 64, 4239, 2021.
- [23] 封达. Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 211, 2021.
- [24] 汪昭. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 206, 2020.
- [25] 康东伟. Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs. ACS INFECTIOUS DISEASES, 6, 2225, 2020.
- [26] 康东伟. Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery. ACS Medicinal Chemistry Letters, 9, 370, 2018.
- [27] Yang, Yang. Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d] pyrimidine non-nucleoside inhibitors. Elife, 7, 2018.