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个人信息Personal Information
研究员 硕士生导师
性别：男
学历：博士研究生毕业
学位：医学博士学位
在职信息：在职
所在单位：药学院
入职时间：2020-10-22
学科：药物化学
联系方式：18663770120
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- [1] 黄伯世. Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies. Journal of Medicianal Chemistry, 64, 13604-13621, 2021.
- [2] 黄伯世. First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1348, 2018.
- [3] 郑义. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 5, 2020.
- [4] 刘新泳. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov, 2019.
- [5] 刘新泳. Overview of Recent Strategic Advances in Medicinal Chemistry. J Med Chem, 2019.
- [6] 刘新泳. Development of a practical synthesis of etravirine via a microwave-promoted amination. chemistry central Journal, 2018.
- [7] 黄伯世. Design, synthesis, and biological evaluation of piperidinyl-substituted [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential anti-HIV-1 agents with reduced cytotoxicity. Chemical Biology & Drug Design, 97, 67, 2021.
- [8] 张涛. The development of an effective synthetic route of rilpivirine. BMC CHEMISTRY, 15, 2021.
- [9] 姜向毅. Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp.... European Journal of Medicinal Chemistry, 213, 2021.
- [10] 孙彦莹. Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 214, 2021.
- [11] 高萍. Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C. BIOORGANIC & MEDICINAL CHEMISTRY Journal, 30, 2021.
- [12] 封达. Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 211, 2021.
- [13] 武高禅. Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 158, 478, 2018.
- [14] 康东伟. Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. ACS Medicinal Chemistry Letters, 8, 1188, 2017.
- [15] 康东伟. Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. Journal of Medicinal Chemistry, 60, 4424, 2017.
- [16] 张硕. Efficient drug discovery by rational lead hybridization based on crystallographic overlay. Drug Discovery Today, 24, 805, 2019.
- [17] 康东伟. Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Propertie.... 《Journal of Medicinal Chemistry》, 62, 1484, 2019.
- [18] 康东伟. Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. 《Journal of Medicinal Chemistry》, 63, 1298, 2020.
- [19] 康东伟. Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. 《Journal of Medicinal Chemistry》, 63, 4837, 2020.
- [20] 康东伟. In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 193, 2020.