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个人信息Personal Information
教授 博士生导师 硕士生导师
性别：男
毕业院校：山东大学
学历：研究生(博士)毕业
学位：医学博士学位
在职信息：在职
所在单位：药学院
入职时间：2013-02-28
联系方式：zhangyingjie@sdu.edu.cn
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- [61] 张颖杰 and 徐文方. Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse. Drug Discov. Ther., 2015.
- [62] 张颖杰 and 徐文方. Isoform-selective histone deacetylase inhibitors: the trend and promise of disease treatment. Epigenomics, 2015.
- [63] 张颖杰 and 徐文方. Design, Synthesis, and Antitumor Evaluation of 4？Amino-2 (1H)？pyrazole Derivatives as JAKs Inhibitors. ACS Med. Chem. Lett., 2016.
- [64] 张颖杰 and 徐文方. VEGF signal system: the application of antiangiogenesis.. Curr. Med. Chem., 2014.
- [65] 张颖杰 and 徐文方. Discovery of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl) -sulfonamide derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological .... Bioorg. Med. Chem., 2014.
- [66] 张颖杰 and 徐文方. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem. Biol. Drug Des, 2013.
- [67] 张颖杰 and 徐文方. Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group. ACS Med. Chem. Lett., 2013.
- [68] 张颖杰. Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents. Mini. Rev. Med. Chem., 13, 2014, 2013.
- [69] 张颖杰. Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group.. ACS Med. Chem. Lett., 4, 235, 2013.
- [70] 张颖杰. Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis andtumor growth.. Eur. J. Med. Chem., 64, 377, 2013.
- [71] 张颖杰. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.. Chem. Biol. Drug Des., 82, 125, 2013.
- [72] 徐文方 , 张颖杰 and 曹江营. Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Bioorganic & medicinal chemistry, 26, 3145, 2018.
- [73] 张颖杰 , 徐文方 and 尹浩. 卡非佐米合成路线图解. 《中国药物化学杂志》, 27, 415, 2017.
- [74] 杨新颖 , 徐文方 , 张颖杰 and 闫玉刚. G蛋白偶联受体40激动剂TAK-875亚砜类似物的合成、绝对构型确证及生物活性研究. 《有机化学》, 37, 858, 2017.
- [75] 徐文方 , 张颖杰 , 吴敬德 and 李晓杨. Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 134, 185, 2017.
- [76] 张颖杰 and 徐文方. Discovery of a pair of diastereomers as potent HDACs inhibitors: determination of absolute configuration, biological activity comparison and computational study. Rsc Adv., 2013.
- [77] 张颖杰 and 徐文方. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem. Biol. Drug Des, 2013.
- [78] 张颖杰 and 徐文方. Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group. ACS Med. Chem. Lett., 2013.
- [79] 徐文方 , 张颖杰 and 曹江营. Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II. BIOORGANIC & MEDICINAL CHEMISTRY Journal, 27, 978, 2019.
- [80] 徐文方 , 张颖杰 and 梁学武. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. 《Journal of Medicinal Chemistry》, 62, 3898, 2019.