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个人信息Personal Information
教授 博士生导师 硕士生导师
性别：男
毕业院校：山东大学
学历：研究生(博士)毕业
学位：医学博士学位
在职信息：在职
所在单位：药学院
入职时间：2013-02-28
联系方式：zhangyingjie@sdu.edu.cn
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- [41] 徐文方 , 张颖杰 and 刘新泳. Discovery of N-Substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase. J. Med. Chem, 2014.
- [42] 张颖杰 , 徐文方 and 刘新泳. Discovery of N-substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase. J. Med. Chem., 2014.
- [43] 张颖杰 and 徐文方. Discovery of a pair of diastereomers as potent HDACs inhibitors: determination of absolute configuration, biological activity comparison and computational study. Rsc Adv., 2013.
- [44] 张颖杰. Discovery of a pair of diastereomers as potent HDACs inhibitors: determination of absolute configuration, biological activity comparison and computational study.. Rsc Adv., 3, 21106, 2013.
- [45] 张颖杰. Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part II.. Eur. J. Med. Chem., 69, 191, 2013.
- [46] 张颖杰 and 徐文方. Discovery of BC-01, a novel mutual prodrug (hybrid drug) of ubenimex and fluorouracil as anticancer agent. Eur. J. Med. Chem., 2016.
- [47] 张颖杰 and 徐文方. Design, Synthesis and Biological Evaluation of Novel Tamibarotene Derivative as Multitarget Anticancer Agent. Lett. Drug Des. Discov., 2016.
- [48] 张颖杰 and 徐文方. PXD101 analogs with L-phenylglycine-containing branched cap as histone deacetylase inhibitors. Chem. Biol. Drug Des., 2016.
- [49] 张颖杰 and 徐文方. Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors. Bioorg. Med. Chem., 2016.
- [50] 张颖杰 and 徐文方. Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU. Med. Chem., 2016.
- [51] 张颖杰 and 徐文方. Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity. Eur. J. Med. Chem., 2015.
- [52] 张颖杰 and 徐文方. Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro.. Bioorg. Med. Chem., 2015.
- [53] 张颖杰. Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity. Bioorg. Med. Chem., 2015.
- [54] 张颖杰 and 徐文方. Histone deacetylase inhibitors merged with protein tyrosine kinase inhibitors. Drug Discov. Ther., 2015.
- [55] 张颖杰 and 徐文方. Progress of HDAC inhibitor panobinostat in the treatment of cancer. Curr. Drug Targets, 2014.
- [56] 张颖杰 and 徐文方. Discovery of the First N-hydroxycinnamamide-based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity. J. Med. Chem., 2014.
- [57] 张颖杰. Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity. Bioorg. Med. Chem., 2016.
- [58] 张颖杰 and 张彩. Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by induction p21WAF1 expression and cell cycle arrest. Anti-Cancer Drugs, 2014.
- [59] 张颖杰 and 徐文方. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorg. Med. Chem., 2015.
- [60] 张颖杰. Development of N-hydroxybenzamide derivatives with indole containing cap group as histone deacetylases inhibitors. Bioorg. Med. Chem., 2015.