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展鹏

教授博士生导师硕士生导师
性别：男
毕业院校：山东大学
学历：博士研究生毕业
学位：医学博士学位
所在单位：药学院
入职时间： 2010-07
所属院系：药学院
办公地点：山东大学国家大学生科技园（二环南路）3号楼14层1435房间
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[21] . The Quinone-Derived Small Molecule M5N32 Is an Effective Anti-Helicobacter pylori Agent Both In Vivo and In Vitro. JOURNAL OF INFECTIOUS DISEASES, 2022.
[22] 黄伯世. Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies. Journal of Medicianal Chemistry, 64, 13604-13621, 2021.
[23] 黄伯世. First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1348, 2018.
[24] . GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy. ACTA PHARMACOLOGICA SINICA, 2023.
[25] 郑义. SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 7, 2022.
[26] 郑义. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 5, 2020.
[27] 展鹏. Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. J Med Chem, 2020.
[28] 刘新泳. Strategies for the Discovery of Target-Specifific or Isoform-Selective Modulators. Journal of Medicinal Chemistry, 2015.
[29] 展鹏. Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. J Med Chem, 2020.
[30] 陶昱岑. Medicinal chemistry insights into novel CDC25 inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 201, 2020.
[31] 展鹏. Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. J Med Chem, 2020.
[32] 展鹏. Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.. J Med Chem, 2020.
[33] 刘新泳. Molecular design opportunities presented by solvent-exposed regions of target proteins. Med Res Rev., 2019.
[34] 刘新泳. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov, 2019.
[35] 刘新泳. Overview of Recent Strategic Advances in Medicinal Chemistry. J Med Chem, 2019.
[36] 刘新泳. Development of a practical synthesis of etravirine via a microwave-promoted amination. chemistry central Journal, 2018.
[37] 黄伯世. Design, synthesis, and biological evaluation of piperidinyl-substituted [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential anti-HIV-1 agents with reduced cytotoxicity. Chemical Biology & Drug Design, 97, 67, 2021.
[38] 张涛. The development of an effective synthetic route of rilpivirine. BMC CHEMISTRY, 15, 2021.
[39] 姜向毅. Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp(3) values and favorable drug-like properties. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 213, 2021.
[40] 孙彦莹. Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 214, 2021.

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