Zhe Zhang
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Name (Simplified Chinese):Zhe Zhang
Name (English):Zhe Zhang
Name (Pinyin):Zhang Zhe
Date of Employment:2021-01-27
School/Department:School of Basic Medical Sciences
Administrative Position:Professor
Education Level:Postgraduate (Doctoral)
Business Address:Room 209, Electron Microscopy Building, No.44 Wenhua Xi Road, Shandong University School of Basic Medical Sciences, Ji'nan, Shandong 250012, P.R.China
Gender:Male
Contact Information:zhezhang@sdu.edu.cn
Degree:Doctor
Status:Employed
Other Post:Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), 赣南医学院学报, 中国生物工程杂志
Alma Mater:Tsinghua University
Whether on the job:1
Discipline:Genetics
Developmental Biology
Biochemistry and Molecular Biology
Academic Honor:
Honors and Titles:
Hits:
Journal:Protein & cell
Abstract:Mitochondrial complex I is important for cellular ATP production by transporting electrons and generating proton gradient across the mitochondrial inner membrane (Hirst, 2013). It is also a major cellular locus where electron leakage to oxygen produces superoxide, an ROS (reactive oxygen species), particularly under oxidative stress conditions. Dysfunctional complex I contributes to the most common oxidative phosphorylation disorder in humans, with many identified genetic mutations in complex I subunits causing a variety of human disorders including Leigh syndrome, encephalomyopathy, cardiomyopathy, parkinsonism and hereditary optic neuropathy (Hirst, 2013; Guo et al., 2017). In addition, complex I is the major target of many parkinsonismcausing neurotoxins including rotenone and MPTP.
All the Authors:Zhe Zhang
First Author:Shuo Luo#,Song Chen#
Indexed by:Journal paper
Correspondence Author:Dengke Ma*
Document Code:6
Translation or Not:no
Date of Publication:2019-08-01
Included Journals:SCI
Attachments:
