Zhe Zhang
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Name (Simplified Chinese):张哲
Name (English):Zhe Zhang
Name (Pinyin):Zhang Zhe
Date of Employment:2021-01-27
School/Department:School of Basic Medical Sciences
Administrative Position:Professor
Education Level:Postgraduate (Doctoral)
Business Address:Room 209, Electron Microscopy Building, No.44 Wenhua Xi Road,
Shandong University School of Basic Medical Sciences, Ji'nan, Shandong
250012, P.R.China
Gender:Male
Contact Information:
Degree:Doctor
Status:Employed
Other Post:Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), Current Pharmaceutical Biotechnology, 赣南医学院学报, 中国生物工程杂志，解剖科学进展
Alma Mater:Tsinghua University
College:Cheeloo College of Medicine
Discipline:Genetics
Developmental Biology
Biochemistry and Molecular Biology
Our laboratory will focus on identifying new regulatory molecules in tissue fibrosis and neurodegenerative diseases through the nematode's forward (EMS mutagenesis) and reverse genetics methods (RNAi library screening and CRISPR/Cas9 genome targeted editing). And using in vivo microscopic imaging, Chip-seq and yeast two hybridization technologies to systematically analyze the subcellular localization and dynamic changes of these regulatory factors during extracellular matrix (ECM) remodeling and neuron degeneration process, to clarify the in vivo functions and molecular regulation mechanisms. Combining the results from C. elegans with human cell line and mouse models, our lab anticipates to verify the function of regulatory factors, reveal the molecular regulatory network of extracellular matrix remodeling and neuron degradation.
