The research group is dedicated to investigating the molecular mechanisms of cellular homeostasis, metabolic imbalance, and aging-related diseases. We primarily focus on the role of organelle dysfunction, particularly the lysosome and endoplasmic reticulum (ER), and key metabolic pathways involving lipids and vitamins in driving organismal aging, reproductive decline, and programmed cell death (e.g., ferroptosis). Based on these insights, we aim to develop novel therapeutic and longevity strategies through metabolic intervention.

We utilize techniques such as multi-dimensional live-cell microscopy, high-resolution lipidomics/metabolomics analysis, immunofluorescence/confocal microscopy, biochemical assays, and mass spectrometry (MS) identification to systematically analyze the subcellular localization, dynamic interactions, and metabolic reprogramming of relevant regulatory factors during processes like organismal aging, germline degeneration, and ferroptosis. This clarifies their in vivo function and molecular regulatory mechanisms.

By integrating these findings with animal disease models, we validate the function and conservation of these regulatory factors. We also advance protein function characterization and preparation, ultimately aiming to reveal the lysosome-metabolism-aging molecular regulatory network and develop targeted metabolic intervention strategies.