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Education Background
  • 2003-09-01-2009-07-01
    山东大学
    遗传学
  • 1999-09-01-2003-07-01
    山东大学
    生物技术
  • 1996-09-01-1999-07-01
    山东省实验中学
Work Experience
  • 2009-07 — Now
    山东大学基础医学院
Publication
Research direction

1. 基础医学类其他专业

Papers

(1)于卉. “人体结构与功能Ⅱ”课程思政教学探究 .教育教学论坛 .2023 (44):150-153

(2)姜威. GABA transporter 1 is a promising drug target for CUL4B mutation-associated epilepsy .ACTA PHARMACOLOGICA SINICA .2025

(3)曹志远. Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway .PLOS BIOLOGY .2025 ,23 (8)

(4)刘海亭. lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus .Cell Death and Differentiation .2022 ,29 (3):627-641

(5)刘凯旋. CUL4B protects kidneys from acute injury by restraining p53/PAI-1 signaling .Cell Death & Disease .2024 ,15 (12)

(6)于瑞祺. Cullin 4B-RING E3 ligase negatively regulates the immunosuppressive capacity of mesenchymal stem cells by suppressing iNOS .Cell Death and Differentiation .2024

(7)马燕燕. CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK .Cell Death & Disease .2024 ,15 (2)

(8)姜威. The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function .Acta Neuropathologica Communications .2024 (12)

(9)张树永. 化学支持“四新建设”的进展、思路与重点 .大学化学 .2022 :1-7

(10)柳晓晨. CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells .Oncogene .2023

(11)范玉佳. Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis .Cell Death and Differentiation .2022 (9)

(12) CUL4B facilitates HBV replication by promoting HBx stabilization .CANCER BIOLOGY & MEDICINE .2021 (1)

(13)王立言. 医学电镜虚拟仿真实验教学系统的构建与应用 .中国组织化学与细胞化学杂志 .2023 ,32 (02):218

(14)王茹. Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFκB signaling .Cell Death & Disease .2023 (14)

(15)于瑞祺. CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ .BONE RESEARCH .2023 ,11 (1)

(16)王玉风. A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility .JOURNAL OF ASSISTED REPRODUCTION AND GENETICS .2023 ,40 (1):75-81

(17)范玉佳. Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis .Cell Death and Differentiation .2022

(18)郭今心. “新医科”背景下大学化学基础课教学改革路径的思考 .《大学化学》 .2022 ,38 (3):191

(19)王宇星. Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12 .ONCOGENESIS .2023 ,12 (1)

(20) KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1 .MOLECULAR CANCER .2021 (1)

(21)龚瑶琴. Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis. .Cell Death and Differentiation .2022 (29):1673

(22)赵伟. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain .Human Molecular Genetics .2015 ,24 (16):4686-4697

(23)李妍. Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer .Oncogene .2022 ,41 (3):361

(24)刘海亭. lncRNA THAP7-AS1, transcriptionally activated by SP1 and post- transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus .Cell Death and Differentiation .2022 (3)

(25)夏阳阳. Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p .BIOCHEMICAL PHARMACOLOGY .2021 ,188

(26)夏阳阳. Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p .BIOCHEMICAL PHARMACOLOGY .2021 (188)

(27)刘磊. KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1 .Molecular Cancer .2021 (1)

(28)王勇. Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma CellsviaInhibiting CDK4-RB Pathway .FRONTIERS IN PHARMACOLOGY .2020 ,11

(29)柳晓晨. The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer .Oncogene .2020 ,39 (17):3588

(30)王勇. Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway .FRONTIERS IN PHARMACOLOGY .2020 (7)

(31)刘磊. KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1 .2021 ,20 (1)

(32)叶翔. CUL4B Promotes Temozolomide Resistance in Gliomas by Epigenetically Repressing CDNK1A Transcription .FRONTIERS IN ONCOLOGY .2021 ,11

(33)陈守臻. CUL4B promotes aggressive phenotypes of renal cell carcinoma via upregulating c-Met expression .The International Journal of Biochemistry& Cell Biology .2021 ,130

(34)Yaoqin Gong. The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer .Oncogene .2020 ,39 (17):3588

(35)Yaoqin Gong. CRL4B interacts and coordinates with SIN3A/HDAC complex to repress CDKN1A in driving cell cycle progression. .J Cell Sci .2014 ,127 :4679

(36)Yaoqin Gong. Sp1 and CREB regulate basal transcription of the human SNF2L gene. .Biochem Biophys Res Commun. .2008 ,368 (2):438

(37)Yaoqin Gong. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. .J Cell Biol. .2013 ,200 (6):743

(38)Yaoqin Gong. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. .PLoS ONE. .2012 ,7 (5):37070

(39)Yaoqin Gong. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. .BMC Genet. .2010 ,11 (1):1

(40)Yaoqin Gong. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. .Human Molecular Genetics .2015 ,24 (16):4686

(41)Sun, Shuna. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes .Cell Death & Disease .2019 ,10

(42)王彬. New nor-clerodane-type furanoditerpenoids from the rhizomes of Tinospora capillipes .Phytochemistry Letters .2016 ,15 :225

(43)Yaoqin Gong. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. .Cancer Cell .2012 ,22 (6):781

(44)Yaoqin Gong. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. .J Cell Biol. .2013 ,200 (6):743

(45)李波漩. Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells .Scientific Reports .2017 ,7

(46)弭军. Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma .MOLECULAR ONCOLOGY .2017 ,11 (3):305

(47)邵常顺. Resveratrol modulates angiogenesis through the GSK3β/β-catenin/TCF-dependent pathway in human endothelial cells. .Biochem Pharmacol. .2010 ,80 (9):1386

(48)邵常顺. Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks. .Plos one .2011 ,6 (4):e18618-1

(49)邵常顺. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51 .Cancer Biology and Therapy .2015 ,16 (10):1548

(50)Yaoqin Gong. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. .Cancer Cell .2012 ,22 (6):781

(51)Yaoqin Gong. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. .Human Molecular Genetics .2015 ,24 (16):4686

(52)Yaoqin Gong. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. .J Cell Biol. .2013 ,200 (6):743

(53)Yaoqin Gong. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. .PLoS ONE. .2012 ,7 (5):e37070

(54)邹永新. Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression .Journal of biological chemistry .2009

(55)邹永新. Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression .Journal of biological chemistry .2009 ,284 (48):33320

(56)Yaoqin Gong. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. .BMC Genet. .2010 ,11 (1):12-1

(57)弭军. Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma .MOLECULAR ONCOLOGY .2017 , 11 (3):305

(58)邵常顺. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51 .Cancer Biology and Therapy .2015 ,16 (10):1548

(59)Yaoqin Gong. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. .Human Molecular Genetics .2015 ,24 (16):4686

(60)Yaoqin Gong. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. .BMC Genet. .2010 ,11 (1):12-1

(61)李波漩. Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells .scientific reports .2017 , 7

(62)邵常顺. Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks. .Plos one .2011 ,6 (4):e18618-1

(63)Yaoqin Gong. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. .Human Molecular Genetics .2015 ,24 (16):4686

(64)Yaoqin Gong. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. .PLoS ONE. .2012 ,7 (5):e37070

(65)Yaoqin Gong. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. .BMC Genet. .2010 ,11 (1):12-1

(66)邵常顺. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51 .Cancer Biology and Therapy .2015 ,16 (10):1548

(67)Yaoqin Gong. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. .J Cell Biol. .2013 ,200 (6):743

(68)邵常顺. Resveratrol modulates angiogenesis through the GSK3β/β-catenin/TCF-dependent pathway in human endothelial cells. .Biochem Pharmacol. .2010 ,80 (9):1386

(69)弭军. Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma .MOLECULAR ONCOLOGY .2017 , 11 (3):305

(70)邹永新. Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression .Journal of biological chemistry .2009 ,284 (48):33320

(71)Yaoqin Gong. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. .Cancer Cell .2012 ,22 (6):781

Patents

1. 一种治疗肾细胞癌的药物组合物及应用

2. 汉黄芩素在制备治疗肾细胞癌药物中的应用

3. 一种治疗肾细胞癌的药物组合物及应用

4. 汉黄芩素在制备治疗肾细胞癌药物中的应用

Student Information
  • 周子涵  2023-09-23 Hits:[] Times
  • 张晶  2023-09-23 Hits:[] Times
  • 周雅迪  2023-09-23 Hits:[] Times
  • 展家凤  2023-09-23 Hits:[] Times
  • 樊博文  2023-09-23 Hits:[] Times
  • 向璐  2020-08-07 Hits:[] Times
  • 巩丽  2019-04-18 Hits:[] Times
  • 沈阳丽  2019-04-18 Hits:[] Times
  • 田菲  2019-04-18 Hits:[] Times
  • 赵慧  2019-04-18 Hits:[] Times
  • 鲁娟娟  2019-04-17 Hits:[] Times
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