代表性研究论文（第一作者^#/通讯作者*）

Zheng W^#, Wang Y^#, Cui J^#, Guo G, Li Y,Hou J, Tu Q, Yin Y, Stewart F*, Zhang Y*, Bian X*, Wang X*. ReaL-MGE is a tool for enhanced multiplex genome engineering and application to malonyl-CoA anabolism. Nat Commun. 2024,15, 9790. https://doi.org/10.1038/s41467-024-54191-4

Chen H^#, Zhong L^#, Zhou H^#,  Bai X, Sun T, Wang X, Zhao Y, Ji X, Tu Q, Zhang Y, Bian X*. Biosynthesis and Engineering of the Nonribosomal Peptides with a C-terminal Putrescine. Nat Commun. 2023, 14(1):6619. doi: 10.1038/s41467-023-42387-z.

Chen H^#, Zhong L^#, Zhou H^#, Sun T, Zhong G, Tu Q, Zhuang Y, Bai X, Wang X, Xu J, Xia L, Shen Y, Zhang Y*, Bian X*. Biosynthesis of Glidomides and Elucidation of Different Mechanisms for Formation of β-OH Amino Acid Building Blocks. Angew Chem Int Ed. 2022, 61(35):e202203591. Selected to be highlighted as the frontispiece at the beginning of the Research Article section.

Shen Q^#, Zhou H^#, Dai G, Zhong G, Huo L, Li A, Liu Y, Yang M, Ravichandran V, Zheng Z, Tang YJ, Jiao N, Zhang Y, Bian X*. Characterization of a Cryptic NRPS Gene Cluster in Bacillus velezensis FZB42 Reveals a Discrete Oxidase Involved in Multithiazole Biosynthesis. ACS Catalysis. 2022, 12(6): 3371-3381. Highlight in Hot off the Press of NPR (Nat. Prod. Rep., 2022. 39, 1117-1121).

Wang X^#, Zheng W^#, Zhou H, Tu Q, Tang YJ, Stewart AF*, Zhang Y*, Bian X*. Improved dsDNA recombineering enables versatile multiplex genome engineering of kilobase-scale sequences in diverse bacteria. Nucleic Acids Res. 2022, 50(3): e15. NAR Novel Method.

Liu J, Zhou H, Yang Z, Wang X, Chen H, Zhong L, Zheng W, Niu W, Wang S, Ren X, Zhong G, Wang Y, Ding X, Müller R, Zhang Y, Bian X*. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria. Nat Commun. 2021, 12(1): 4347. Editors’ Highlights in “Biotechnology and methods” of Nature Communications.

Zhong L^#, Diao X^#, Zhang N^#, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*, Wu D*, Bian X*. Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis. Nat Commun. 2021, 12(1):296. Editors’ Highlights in “Organic chemistry and chemical biology” of Nature Communications.

Zhang X, Xu X, You C, Yang C, Guo J, Sang M, Geng C, Cheng F, Du L, Shen Y, Wang S, Lan H, Yang F, Li Y, Tang YJ, Zhang Y, Bian X*, Li S*, Zhang W*. Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase. Angew Chem Int Ed. 2021, 60(46): 24418-24423. Designated as a “Very Important Paper (VIP)” by the journal’s referees (Top 5%). Recommended in Faculty Opinions (three stars，Exceptional). Highlight in “Hot off the press” of NPR.

Wang X^#, Zhou H^#, Chen H^#, Jing X, Zheng W, Li R, Sun T, Liu J, Fu J, Huo L, Li YZ, Shen Y, Ding X, Müller R, Bian X*, Zhang Y*. Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species. Proc Natl Acad Sci USA. 2018, 115 (18): E4255-E4263. Recommended by Curr Opin Microbiol (2019, 51: 9-15) and Curr Opin Chem Biol（2021, 60: 47-54）.

Bian X, Plaza A, Zhang Y*, Müller R*. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety. Chem Sci 2015, 6(5): 3154-3160.

Fu J^#, Bian X^#, Hu S, Wang H, Huang F, Seibert PM, Plaza A, Xia L, Müller R*, Stewart AF*, Zhang Y*. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol. 2012, 30(5):440-6. Highlighted in ‘Cover Paper’ and ‘News and Views’ of Nature Biotechnology, and Research Highlighted in Nature Methods; HZI 'Paper of the Month' award in July 2012.

代表性综述论文（第一作者^#/通讯作者*）

Long Q, Zhou W, Zhou H, Tang Y, Chen W*, Liu Q*, Bian X*. Polyamine-containing Natural Products: Structure, Bioactivity, and Biosynthesis. Nat Prod Rep. 2024, 41, 525 - 564.. doi: 10.1039/d2np00087c.

Liu J, Wang X, Dai G, Zhang Y, Bian X*. Microbial Chassis Engineering Drives Heterologous Production of Complex Secondary Metabolites. Biotechnol Adv. 2022, 59: 107966. doi: 10.1016/j.biotechadv.2022.107966

Huo L, Hug JJ, Fu C, Bian X*, Zhang Y*, Müller R*. Heterologous expression of bacterial natural product biosynthetic pathways. Nat Prod Rep. 2019 Oct 16;36(10):1412-1436. doi: 10.1039/c8np00091c. ESI Hot Paper and Highly Cited Paper

Ongley SE^#, Bian X^#, Neilan BA*, Müller R*. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h.

年度发表论文目录

2024

Zheng W^#, Wang Y^#, Cui J^#, Guo G, Li Y,Hou J, Tu Q, Yin Y, Stewart F*, Zhang Y*, Bian X*, Wang X*. ReaL-MGE is a tool for enhanced multiplex genome engineering and application to malonyl-CoA anabolism. Nat Commun. 2024,15, 9790. https://doi.org/10.1038/s41467-024-54191-4

Niu W, Liu J, Duan Y, Zhong L, Pang L, Zhong G, Zhang Y, Bian X*. Biosynthesis of Nonribosomal Peptides Chitinimides Reveal a Special Type of Thioesterase Domains. Chem Eur J. 2024 Sep 19: e202402763. doi: 10.1002/chem.202402763.

Long Q, Zhou W, Zhou H, Tang Y, Chen W*, Liu Q*, Bian X*. Polyamine-containing Natural Products: Structure, Bioactivity, and Biosynthesis. Nat Prod Rep. 2024, 41(4): 525 - 564.  doi: 10.1039/d2np00087c. Cover paper

Gu S, Shao Y, Rehm K, Bigler L, Zhang D, He R, Xu R, Shao J, Jousset A, Friman V, Bian X, Wei Z*, Kümmerli R*, Li Z*. From sequence to molecules: Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways. eLife. 2024, 13: RP96719. https://doi.org/10.7554/eLife.96719.3

Wang, S., Huang, J., Du, Y. Huang W, Xue Y, Xu X, Zhong G, Shi Y, Hong B, Bian X, Liu W*. Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization. Sci. China Chem. 2024. https://doi.org/10.1007/s11426-024-2188-x

刘婷婷，刘嘉琪，刘洋，卞小莹*。基于反转录子的微生物基因编辑技术研究进展。微生物学通报. DOI: 10.13344/j.microbiol.china.240587

崔锦程，崔洁，卞小莹*。生产双链RNA工程菌的研究进展。生物工程学报.  2024, DOI: 10.13345/j.cjb.240571

唐海峰，戴昀峰，扶洋帆，邹一明，高占，盘赛昆，王文彬，杨杰*，卞小莹*。枯草芽孢杆菌中bacilosarcin B对美人鱼发光杆菌的抑菌机理。微生物学通报. 2024, 51(2): 419-432. DOI: 10.13344/j.microbiol.china.230732

张雨欣, 王美燕, 李殿怡, 司军, 卞小莹, 牛国清, 刘蓉. 一株产灵菌红素黏质沙雷氏菌的分离鉴定及其基因组分析. 微生物学报. 2024, DOI: 10.13343/j.cnki.wsxb.20240303.

2023

Chen H^#, Zhong L^#, Zhou H^#,  Bai X, Sun T, Wang X, Zhao Y, Ji X, Tu Q, Zhang Y, Bian X*. Biosynthesis and Engineering of the Nonribosomal Peptides with a C-terminal Putrescine. Nat Commun. 2023, 14(1):6619. doi: 10.1038/s41467-023-42387-z. 

Liu Y^#, Zhou H^#, Zhao S, Hao X, Dai G, Zhong L, Ren X, Sui H, Zhang Y*, Yan F*, Bian X*. Biosynthesis of trans-AT PKS-derived Shuangdaolides Featuring a trans-acting Enzyme for Online Epoxidation. ACS Chem Biol. 2023 Dec 15;18(12):2474-2484. doi: 10.1021/acschembio.3c00368.

Chen H^#, Bai X^#, Sun T, Wang X, Zhang Y*, Bian X*, Zhou H*. The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli. Molecules. 2023; 28(19):6937. https://doi.org/10.3390/molecules28196937.

Bai X, Chen H, Ren X, Zhong L, Wang X, Ji X, Zhang Y, Wang Y, Bian X*. Heterologous Biosynthesis of Complex Bacterial Natural Products in Burkholderia gladioli. ACS Synth Biol. 2023, 12(10):3072-3081. doi: 10.1021/acssynbio.3c00389.

Wang X, Zhou H, Ren X, Chen H, Zhong L, Bai X, Bian X*. Recombineering enables genome mining of novel siderophores in a non-model Burkholderiales strain. Engineering Microbiology, 2023 Sep, 3(3): 100106, doi: 10.1016/j.engmic.2023.100106.

Dai G^#, Sun J^#, Peng X, Shen Q, Wu C, Sun Z, Sui H, Ren X, Zhang Y, Bian X*. Astellolides R-W, Drimane-Type Sesquiterpenoids from an Aspergillus parasiticus Strain Associated with an Isopod. J Nat Prod. 2023 Jul 28;86(7):1746-1753. doi: 10.1021/acs.jnatprod.3c00215

Duan Y, Niu W, Pang L, Mu D-S, Du Z-J, Zhang Y*, Bian X* and Zhong G*. Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue. Front. Microbiol. 2023 Jul 10; 14:1181125. doi: 10.3389/fmicb.2023.1181125

Pang L, Niu W, Duan Y, Bian X, Zhang Y, Zhong G*. Characterization of GvgD and GvgH encoded in the biosynthetic gene cluster of 4-formylaminooxyvinylglycine. Org. Chem. Front. 2023,10, 2782-2789. 

2022

Chen H^#, Zhong L^#, Zhou H^#, Sun T, Zhong G, Tu Q, Zhuang Y, Bai X, Wang X, Xu J, Xia L, Shen Y, Zhang Y*, Bian X*. Biosynthesis of Glidomides and Elucidation of Different Mechanisms for Formation of β-OH Amino Acid Building Blocks. Angew Chem Int Ed. 2022, 61(35): e202203591. doi: 10.1002/anie.202203591. Selected to be highlighted as the frontispiece at the beginning of the Research Article section.

Liu J, Wang X, Dai G, Zhang Y, Bian X*. Microbial Chassis Engineering Drives Heterologous Production of Complex Secondary Metabolites. Biotechnology Advances. 2022, 59: 107966. doi: 10.1016/j.biotechadv.2022.107966

Shen Q^#, Zhou H^#, Dai G, Zhong G, Huo L, Li A, Liu Y, Yang M, Ravichandran V, Zheng Z, Tang YJ, Jiao N, Zhang Y, Bian X*. Characterization of a Cryptic NRPS Gene Cluster in Bacillus velezensis FZB42 Reveals a Discrete Oxidase Involved in Multithiazole Biosynthesis. ACS Catalysis. 2022, 12(6): 3371-3381. doi: 10.1021/acscatal.1c05131. Highlight in Hot off the Press of Natural Product Reports (Nat. Prod. Rep., 2022. 39, 1117-1121).

Wang X^#, Zheng W^#, Zhou H, Tu Q, Tang YJ, Stewart AF*, Zhang Y*, Bian X*. Improved dsDNA recombineering enables versatile multiplex genome engineering of kilobase-scale sequences in diverse bacteria. Nucleic Acids Res. 2022 Feb 22; 50(3):e15. doi: 10.1093/nar/gkab1076

Dai G, Shen Q, Zhang Y, Bian X*. Biosynthesis of Fungal Natural Products Involving Two Separate Pathway Crosstalk. J Fungi. 2022 Mar 21, 8(3), 320. doi: 10.3390/jof8030320

Wang X^#, Liu J^#, Zheng W, Zhang Y*, Bian X*. Recombineering-Mediated Genome Editing in Burkholderiales Strains. Methods Mol Biol. 2022; 2479: 21-36. doi: 10.1007/978-1-0716-2233-9_3.

Pang L, Niu W, Duan Y, Huo L, Li A, Wu J, Zhang Y, Bian X*, Zhong G*. In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2’-aminocyclopropyl) alanine biosynthesis. Engineering Microbiology 2022 Mar, 2(1): 100007. doi: 10.1016/j.engmic.2021.100007.

白先平，陈汉娜，钟林，王邢艳，卞小莹*。WAP-8294A类抗生素及其高效合成的研究进展. 中国抗生素杂志. 2022年5月, 47(5): 417-425.

Wang Z-J^#, Liu X^#, Zhou H^#, Liu Y, Zhong L, Wang X, Tu Q, Huo L, Yan F, Gu L, Müller R, Zhang Y*, Bian X*, Xu X*. Engineering of Burkholderia thailandensis strain E264 serves as a chassis for expression of complex specialized metabolites. Front. Microbiol. 2022 Nov 17;13:1073243. 

Duan Y, Niu W, Pang L, Bian X, Zhang Y, Zhong G. Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides. Int J Mol Sci. 2022 Jun 29; 23(13): 7231. https://doi.org/10.3390/ijms23137231

Gao H, Bian X. Editorial: Microbial Siderophores: Biosynthesis, Regulation, and Physiological and Ecological Impacts. Front. Microbiol. 2022 Apr 18;13: 892485. doi: 10.3389/fmicb.2022.892485.

Bian Z, Wang M, Yang Y, Wu Y, Ni H, Yu X, Shi J, Chen H, Bian X, Pan D, Li T, Zhang Y, Yu L, Jiang L, Tu Q. Enhanced growth of ginger plants by an eco-friendly nitrogen-fixing Pseudomonas protegens inoculant in greenhouse fields. J Sci Food Agric. 2022, 102: 3038-3046. DOI: 10.1002/jsfa.11645

Liu Q, Zhang L, Wang Y, Zhang C, Liu T, Duan C, Bian X, Guo Z, Long Q, Tang Y, Du J, Liu A, Dai L, Li D, Chen W. Enhancement of edeine production in Brevibacillus brevis X23 via in situ promoter engineering. Microb Biotechnol. 2022 Feb;15(2):577-589. doi: 10.1111/1751-7915.13825.

2021

Liu J, Zhou H, Yang Z, Wang X, Chen H, Zhong L, Zheng W, Niu W, Wang S, Ren X, Zhong G, Wang Y, Ding X, Müller R, Zhang Y, Bian X*. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria. Nature Commun. 2021 Jul 23; 12: 4347. DOI : 10.1038/s41467-021-24645-0. Editors’ Highlights in “Biotechnology and methods” of Nature Communications.

Zhong L^#, Diao X^#, Zhang N^#, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*, Wu D*, Bian X*. Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis. Nature Commun. 2021 Jan 12;12(1):296. doi: 10.1038/s41467-020-20548-8. Editors’ Highlights in “Organic chemistry and chemical biology” of Nature Communications.

Zhang X, Xu X, You C, Yang C, Guo J, Sang M, Geng C, Cheng F, Du L, Shen Y, Wang S, Lan H, Yang F, Li Y, Tang YJ, Zhang Y, Bian X*, Li S*, Zhang W*. Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase. Angew Chem Int Ed. 2021 Nov 8; 60(46): 24418-24423, doi: 10.1002/anie.202107745. Designated as a “Very Important Paper (VIP)” by the journal’s referees (Top 5%). Recommended in Faculty Opinions by Ikuro Abe (three stars，Exceptional). Highlight in “Hot off the press” of NPR.

Yang J, Zhu Q, Chai J, Xu F, Ding Y, Zhu Q, Lu Z, Khoo KS, Bian X*, Show PL*, Wang S*. Development of environmentally friendly biological algicide and biochemical analysis of inhibitory effect of diatom Skeletonema costatum. Chin Chem Lett. 2021, accepted. doi: 10.1016/j.cclet.2021.09.053

Liu Y, Zhou H, Shen Q, Dai G, Yan F, Li X, Ren X, Sun Q, Tang YJ, Zhang Y, Bian X*. Discovery of Polycyclic Macrolide Shuangdaolides by Heterologous Expression of a Cryptic trans-AT PKS Gene Cluster. Org Lett. 2021 Aug 13. 23(17): 6967-6971. doi: 10.1021/acs.orglett.1c02589.

Shen Q, Dai G, Li A, Liu Y, Zhong G, Li X, Ren X, Sui H, Fu J, Jiao N, Zhang Y*, Bian X*, Zhou H*. Genome-guided Discovery of Highly Oxygenated Aromatic Polyketides, Saccharothrixins D-M, from the Rare Marine Actinomycete Saccharothrix sp. D09. J Nat Prod. 2021 Nov 26; 84(11): 2875-2884. doi: 10.1021/acs.jnatprod.1c00617.

Shen Q, Dai G, Ravichandran V, Liu Y, Zhong Lin, Sui H, Ren X, Jiao N, Zhang Y*, Zhou H*, Bian X*. Saccharochelins A-H, Cytotoxic Amphiphilic Siderophores from the Rare Marine Actinomycete Saccharothrix sp. D09. J Nat Prod. 2021, 84(8):2149-2156. doi: 10.1021/acs.jnatprod.1c00155.

Chen H, Sun T, Bai X, Yang J, Yan F, Yu L, Tu Q, Li A, Tang Y, Zhang Y*, Bian X*, Zhou H*. Genomics-Driven Activation of Silent Biosynthetic Gene Clusters in Burkholderia gladioli by Screening Recombineering System. Molecules. 2021 Jan 29; 26(3):700. doi: 10.3390/molecules26030700.

周海波, 申琪瑶, 陈汉娜, 王宗杰, 李越中, 张友明*, 卞小莹*. 利用异源表达挖掘纤维堆囊菌So0157-2的新型天然产物. 合成生物学 Synth Biol J. 2021, 2 doi: 10.12211/2096-8280.2021-024

Zheng W^#, Wang X^#, Chen Y, Dong Y, Zhou D, Liu R, Zhou H, Bian X, Wang H, Tu Q, Ravichandran V, Zhang Y, Li A*, Fu J*, Yin J*. Recombineering facilitates the discovery of natural product biosynthetic pathways in Pseudomonas parafulva. Biotechnol J. 2021 Jan 23:e2000575. doi: 10.1002/biot.202000575.

Yang J, Zhu Q, Xu F, Yang M, Du H, Bian X, Lu Z, Lu Y, Lu F. Genome Mining, Heterologous Expression, Antibacterial and Antioxidant Activities of Lipoamides and Amicoumacins from Compost-Associated Bacillus subtilis fmb60. Molecules. 2021; 26(7):1892. doi: 10.3390/molecules26071892

Wang H, Liang J, Yue Q, Li L, Shi Y, Chen G, Li YZ, Bian X, Zhang Y, Zhao G, Ding X. Engineering the acyltransferase domain of epothilone polyketide synthase to alter the substrate specificity. Microb Cell Fact. 2021 Apr 21;20(1):86. doi: 10.1186/s12934-021-01578-3.

2020

Zhong L, Ravichandran V, Zhang N, Wang H, Bian X*, Zhang Y*, Li A*. Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions. Int J Mol Sci. 2020 Mar 22;21(6): 2190. doi: 10.3390/ijms21062190.

Ouyang Q, Wang X, Zhang N, Zhong L, Liu J, Ding X, Zhang Y, Bian X*. Promoter screening facilitates heterologous production of complex secondary metabolites in Burkholderiales strains. ACS Synth. Biol.2020 Feb 21;9(2):457-460. doi: 10.1021/acssynbio.9b00459

Chen H^#, Zhou H^#, Sun T, Xu J, Tu Q, Yang J, Zhang Y, Bian X*. Identification of holrhizins E-Q reveals the diversity of nonribosomal lipopeptides in Paraburkholderia rhizoxinica. J Nat Prod. 2020, Feb 28; 83(2):537-541. doi:10.1021/acs.jnatprod.9b00927 

Wang ZJ, Zhou H, Zhong G, Huo L, Tang YJ, Zhang Y*, Bian X*. Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium. Org Lett. 2020 Feb 7; 22(3):939-943. doi: 10.1021/acs.orglett.9b04490.

Zheng W^#, Wang X^#, Zhou H, Zhang Y*, Li A*, Bian X*. Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters. Microb Biotechnol. 2020 Mar;13(2):397-405. doi: 10.1111/1751-7915.13535. Highlighted by Microb Biotechnol (Microb Biotechnol. 2020, 13:1702-1704）.

Liang J^#, Wang H^#, Bian X, Zhang Y, Zhao G, Ding X*. Heterologous redox partners supporting the efficient catalysis of epothilone B biosynthesis by EpoK in Schlegelella brevitalea. Microb Cell Fact. 2020 Sep 15;19(1):180. doi: 10.1186/s12934-020-01439-5.

Yu Y, Wang H, Tang B, Liang J, Zhang L, Wang H, Bian X, Li YZ, Zhang Y, Zhao GP*, Ding X*. Reassembly of the biosynthetic gene cluster enables high epothilone yield in engineered Schlegelella brevitalea. ACS Synth Biol. 2020 Aug 21;9(8):2009-2022. doi: 10.1021/acssynbio.0c00100.

Abbasi MN, Fu J, Bian X, Wang H*, Zhang Y*, Li A*. Recombineering for Genetic Engineering of Natural Product Biosynthetic Pathways. Trends Biotechnol. 2020 Jan 20. doi: 10.1016/j.tibtech.2019.12.018. 

Wang M^#, Bian Z^#, Shi J, Wu Y, Yu X, Yang Y, Ni H, Chen H, Bian X, Li T, Zhang Y, Jiang L*, Tu Q*. Effect of the nitrogen-fixing bacterium Pseudomonas protegens CHA0-ΔretS-nif on garlic growth under different field conditions. Ind Crop Prod. 2020, 145: 111982.  doi: 10.1016/j.indcrop.2019.111982

Jing X^#, Cui Q^#, Li X, Yin J, Ravichandran V, Pan D, Fu J, Tu Q, Wang H*, Bian X*, Zhang Y*. Engineering Pseudomonas protegens  Pf-5  to improve its antifungal activity and nitrogen fixation. Microb Biotechnol. 2020, 13(1):118-133. doi: 10.1111/1751-7915.13335

2019

Huo L, Hug JJ, Fu C, Bian X*, Zhang Y*, Müller R*. Heterologous expression of bacterial natural product biosynthetic pathways. Nat Prod Rep. 2019 Oct 16;36(10):1412-1436. doi: 10.1039/c8np00091c. ESI Hot Paper and Highly Cited Paper

Tang B, Yu Y, Liang J, Zhang Y, Bian X, Zhi X, Ding X. Reclassification of “Polyangium brachysporum” DSM 7029 as Schlegelella brevitalea sp. nov. Int J Syst Evol Microbiol.  2019 Sep;69(9):2877-2883. doi: 10.1099/ijsem.0.003571

Chen H, Bian Z, Ravichandran V, Li R, Sun Y, Huo L, Fu J, Bian X, Xia L, Tu Q, Zhang Y . Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales. Crit Rev Microbiol. 2019 Mar;45(2):162-181. doi: 10.1080/1040841X.2018.1514365. 

Yu F, Jing X, Li X, Wang H, Chen H, Zhong L, Yin J, Pan D, Yin Y, Fu J, Xia L, Bian X, Tu Q*, Zhang Y*. Recombineering Pseudomonas protegens CHA0: An innovative approach that improves nitrogen fixation with impressive bactericidal potency. Microbiol Res. 2019 Jan; 218:58-65

Li R^#, Helbig L^#, Fu J, Bian X, Herrmann J, Baumann M, Stewart AF, Müller R, Li A*, Zips D*, Zhang Y*. Expressing Cytotoxic Compounds in Escherichia coli Nissle 1917 for Tumor-targeting Therapy. Res Microbiol. 2019 Mar;170(2):74-79. doi: 10.1016/j.resmic.2018.11.001.

2018

Wang X^#, Zhou H^#, Chen H^#, Jing X, Zheng W, Li R, Sun T, Liu J, Fu J, Huo L, Li YZ, Shen Y, Ding X, Müller R, Bian X*, Zhang Y*. Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species. Proc Natl Acad Sci U S A. 2018 May 1, 115 (18): E4255-E4263.  doi: 10.1073/pnas.1720941115. Recommended by Curr Opin Microbiol (2019, 51: 9-15) and Curr Opin Chem Biol（2021, 60: 47-54）.

Chen H, Fang Q, Tu Q, Liu C, Yin J, Yin Y, Xia L, Bian X*, Zhang Y*. Identification of a contact-dependent growth inhibition system in the probiotic Escherichia coli Nissle 1917.  FEMS Microbiol Lett. 2018 Jun 1; 365(11): fny102. doi: 10.1093/femsle/fny102.

Xu X, Zhou H, Liu Y, Liu X, Fu J, Li A, Li YZ, Shen Y, Bian X*, Zhang Y*. Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic. J Nat Prod. 2018 Apr 27;81(4):1060-1064. doi: 10.1021/acs.jnatprod.7b00835.

Liu C, Yu F, Liu Q, Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q*, Zhang Y*. Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering. FEMS Microbiol Lett. 2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

2017

郑文韬，张友明*，卞小莹*。Red/ET 同源重组技术及在微生物基因组挖掘中的应用进展。微生物学报 (Acta Microbiologica Sinica), 2017; 57(11): 1735-1746

Bian X^#, Tang B^#, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao G, Ding X*, Müller R*, Zhang Y*. Heterologous production and yields improvement of epothilones in the Burkholderiales strain DSM 7029. ACS Chem Biol. 2017; 12 (7): 1805-1812. doi: 10.1021/acschembio.7b00097. Highlight in Hot off the Press of Natural Product Reports (Nat. Prod. Rep., 2017, 34, 1180-1184).

Yin J, Wang H, Li R, Ravichandran V, Bian X, Li A, Tu Q, Francis Stewart A*, Fu J*, Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus. Curr Top Microbiol Immunol. 2017; 402:195-213. doi: 10.1007/82_2016_57.

2016

Liu Q#, Shen Q#, Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W*, Li D*, Zhang Y*. Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering. Sci Rep. 2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J, Bian X, Li A, Müller R, Stewart AF*, Fu J*, Zhang Y*. RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression. Nat Protoc. 2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R, Bian X, Zhang Y*, Müller R*. Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering. Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

2015

Yin J, Hoffmann M, Bian X, Tu Q, Yan F, Xia L, Ding X, Stewart AF, Müller R*, Fu J*, Zhang Y*. Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2). Sci Rep. 2015 Oct 13;5:15081. doi: 10.1038/srep15081.

Bian X, Plaza A, Zhang Y*, Müller R*. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety. Chemical Science 2015, 6(5): 3154-3160.

Bian X, Plaza A, Yan F, Zhang Y*, Müller R*. Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo. Biotechnol Bioeng. 2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. 

2014

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M, Bian X, Müller R, Fu J*, Stewart AF*, Zhang Y*. A new recombineering system for Photorhabdus and Xenorhabdus. Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. 

Bian X, Huang F, Wang H, Klefisch T, Müller R*, Zhang Y*. Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029. ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.201402199. Epub 2014 Aug 21.

Wang H, Bian X, Xia L, Ding X, Müller R, Zhang Y*, Fu J*, Stewart AF*. Improved seamless mutagenesis by recombineering using ccdB for counterselection. Nucleic Acids Res. 2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. 

2013

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y*, Müller R*. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery. Planta Medica 79(10): 834, 2013

Ongley SE#, Bian X#, Neilan BA*, Müller R*. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. 2013 Q3 Top ten most accessed Natural Product Reports articles (2nd); BABS 'Paper of the Month' award in July 2013, UNSW.

Ongley SE, Bian X, Zhang Y, Chau R, Gerwick WH, Müller R*, Neilan BA*. High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium. ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. BABS 'Paper of the Month' award in June 2013, UNSW.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y*, Müller R*. In vivo evidence for a prodrug activation mechanism during colibactin maturation. ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.201300208. Epub 2013 Jun 6.

2012

Bian X, Plaza A, Zhang Y*, Müller R*. Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli. J Nat Prod. 2012 Sep 28;75(9):1652-5. 2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y*, Müller R*. Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering. ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.201200310. 

Fu J#, Bian X#, Hu S, Wang H, Huang F, Seibert PM, Plaza A, Xia L, Müller R*, Stewart AF*, Zhang Y*. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol. 2012 May;30(5):440-6. doi: 10.1038/nbt.2183. Highlighted in ‘Cover Paper’ and ‘News and Views’ of Nature Biotechnology, and Research Highlighted in Nature Methods; HZI 'Paper of the Month' award in July 2012.

2008

卞小莹，吴文君，王群利，方丽萍。秦岭链霉菌的原生质体再生与诱变育种。微生物学通报, 35(6): 929-933, 2008.

王群利，师宝君，卞小莹，姬志勤。土壤拮抗放线菌的分离及其抗菌活性筛选。植物保护, 34(3): 41-46, 2008.

2005

Luo DQ, Wang F, Bian X, Liu JK*. Rufuslactone, a new antifungal sesquiterpene from the fruiting bodies of the basidiomycete Lactarius rufus. J Antibiot. 58(7): 456-459, 2005.